oncologic meds

general chemotherapy

cyclophosphamide, doxorubicin, vincristine, methotrexate

standard Hodgkin’s tx regimen

ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine)

advanced Hodgkin’s tx regimen

BEACOPP (Bleomycin, Etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), procarbazine, prednisone)

refractory and relapsed newer agents for Hodgkin’s

brentuximab vedotin, nivolumab, bendamustine, pembrolizumab

general hormone therapy

leuprolide (Lupran), anastrozole (Arimidex), letrozole (Femara), tamoxifen (Nolvadex), fulvestrant (Faslodex)

general targeted therapy meds

bevacizumab (Avastin), alectinib (Alecensa), ibrutinib (Imbruvica), imatinib (Gleevec), palbociclib (Ibrance)

general immunotherapy meds

nivolumab (Opdivo), pembrolizumab (Keytruda), atezolizumab (Tecentriq), iplimumab (Yervoy)

immunosuppressive therapy classifcations (6)

anti-inflammatory, anti-proliferative, calcineurin inhibitors, antibody induction agents, mTOR inhibitor (Mammalian Target of Rapamycin), T-Cell Costimulation Blocker

anti-inflammatory agents (2)

prednisone, methylprednisolone (Solumedrol)

anti-inflammatory common side effects (8)

altered fat deposition, cataracts, glaucoma, diabetes, hypertension, fluid retention, bone and muscle wasting, joint disease

anti-proliferative agents (3)

Azathioprine (Imuran), Mycophenolate Mofetil (CellCept), Mycophenolic Acid (Myfortic)

anti-proliferative common side effects (2 broad, 3 specific)

neutropenia, thrombocytopenia

Mycophenolate: diarrhea, GI intolerance, teratogenic

calcineurin inhibitor agents

Cyclosporine, Tacrolimus

calcineurin inhibitor common side effects (6 broad, 2 specific)

nephrotoxicity, diabetes, hypertension, hyperkalemia, tremors, neuropathies

Cyclosporine Modified: hirsutism, gingival hyperplasia

antibody induction agents (3)

polyclonal antibody therapy: anti-thymocyte globulin (Thymoglobulin)

monoclonal Antibody therapy: Basiliximab (Simulect), Alemtuzumab (Campath)

antibody induction agents common side effects (3)

neutropenia, thrombocytopenia, bone marrow suppression

mTOR inhibitor agents (2)

Sirolimus (Rapamune), Everolimus (Zortress)

mTOR inhibitor common side effects (6)

hyperlipidemia, diarrhea, bone marrow suppression, delayed wound healing, mouth ulcers, proteinuria

T-Cell Costimulation Blocker agent

Belatacept (Nulojix)

T-Cell Costimulation Blocker common side effects (4)

Infusion related rxns, anemia, post-transplant lymphoproliferative disease, progressive multifocal leukoencephalopathy (PML) (rare)

Induction therapy drugs

cytarabine (Ara-C, Cytosar)

antitumor abx (anthracycline) → daunorubicin (Cerubidine), idarubicin (Idamycin), mitoxantrone (Novantrone)

known vesicant drugs

Doxorubicin (Adriamycin), Vincristine (Oncovin), Idarubicin (Idamycin)

drugs that could cause SIADH

cytoxan, vincristine, cisplatin

hormone therapy SE

• hot flashes

• fatigue

• tender breasts

• loss of interest in sex

• mood changes

• nausea

• diarrhea

targeted therapy & immunotherapy SE

• fatigue

• cough

• gastrointestinal side effects, such as diarrhea, constipation, nausea, or loss of appetite

• rash

• reaction to the infusion

• flu-like symptoms

chemotherapy SE

bone marrow suppression
fatigue
GI disturbances (includes loss of appetite)
hair loss
low white blood cells, which may make it harder to fight off infections

integumentary & mucosal rxns
mucositis/stomatitis,dysphagia

pulmonary & cardiac effects

reproductive effects

secondary malignancies