Isotype switching & AID and uracil-DNA glycosylase activity

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Last updated 12:39 AM on 2/25/25
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6 Terms

1
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Are recombination events limited to the variable regions of immunoglobulin loci?

No, recombination events also occur in the constant regions of the heavy and light chains.

2
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What is class switch recombination in B cells?

Class switch recombination allows B cells to produce different isotypes of immunoglobulins

3
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What is the purpose of isotype switching in B cells?

It allows B cells to produce immunoglobulins with effector functions suited for the specific tissue and pathogen they are responding to.

4
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What activities are required for isotype switching?

The activities of AID and uracil-DNA glycosylase.

5
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How do the mechanisms behind class switch recombination differ from somatic hypermutation?

The mechanisms are slightly different, but both involve AID activity.

6
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What are switch regions in class switch recombination?

Switch regions (or switch sequences) are located upstream of each constant region (except for the δ region) and contain repetitive target sequences for AID activity.