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Are recombination events limited to the variable regions of immunoglobulin loci?
No, recombination events also occur in the constant regions of the heavy and light chains.
What is class switch recombination in B cells?
Class switch recombination allows B cells to produce different isotypes of immunoglobulins
What is the purpose of isotype switching in B cells?
It allows B cells to produce immunoglobulins with effector functions suited for the specific tissue and pathogen they are responding to.
What activities are required for isotype switching?
The activities of AID and uracil-DNA glycosylase.
How do the mechanisms behind class switch recombination differ from somatic hypermutation?
The mechanisms are slightly different, but both involve AID activity.
What are switch regions in class switch recombination?
Switch regions (or switch sequences) are located upstream of each constant region (except for the δ region) and contain repetitive target sequences for AID activity.