Lipid Solubility and Drug Absorption

These flashcards cover key concepts relating to lipid solubility, pH effects, and drug absorption, focusing on the factors that influence the pharmacokinetics of drugs across lipid membranes.

Lipid Solubility

The ability of a drug to dissolve in lipids, which is crucial for its absorption across lipid membranes.

pH

A measure of acidity or alkalinity in a solution, affecting the ionization state of drugs.

Ionized

Refers to a drug that is charged and typically less lipid soluble, making it harder to be absorbed across membranes.

Non-Ionized

Refers to a drug that is uncharged and usually more lipid soluble, facilitating its absorption across membranes.

Weak Acids

Drugs that can donate protons (H+) and are better absorbed in acidic environments (low pH).

Weak Bases

Drugs that can accept protons (H+) and are better absorbed in alkaline environments (high pH).

pH Trapping

The phenomenon where a drug becomes trapped on one side of a membrane due to changes in ionization state influenced by pH.

Enteric Coating

A protective layer applied to tablets to prevent dissolution in the stomach and ensure absorption occurs in the intestine.

Excipients

Inactive substances used in drug formulations to aid in the manufacturing and delivery of active ingredients.

Controlled Release

A formulation strategy that allows for the slow and uniform release of a drug over time.