Mood/Affect Drugs - PT I DEPRESSION/ANXIETY

Therapy goals for mood/affect drugs

increase understanding, correct irrational thinking, improve coping mechanisms, improve insight, reduce vulnerability

Benzodiazepines prototype

diazepam/valium and alprazolam/xanax

Benzodiazepines syllables

p/lam

Benzodiazepine therapeutic indications

anxiety

Benzodiazepine pharmakokinetics

positive modulator to increase inhibitory effect of gaba

cns depression

benzodiazepines act on

limbic system and ras

limbic system for ___, ras for

emotional control, behavior and input organization

Side effects for Benzodiazepine

CNS depression, paradox anxiety, hypotension, tachycardia, resp depression, cancer risk

Benzodiazepine blackbox warning

4, teratogenic

Benzodiazepine drug interactions

IV can precipitate, smoking decrease effect, disulfiram fluoxetine and cimetidine increase levels

Diazepam IM can be ____ __absorption, so need to inject__ __*into a*__ ____ muscle__

inconsistent, slowly, large

Reverse sedation of benzodiazepine with ______

IV flumazenil

SSRI prototype

fluozetine/prozac

syllables for ssris

pram, ine

Therapeutic indication for ssri

antidepressant

pharmacokinetics of ssris

presynaptic neuron, blocks reuptake of serotonin, CNS excitation

SSRIs have a ____ half life

long

Side effects/adverse effects of SSRIs

serotonin syndrome, hyponatremia, increased sodium excretion, insomnia

Serotonin syndrome

kidney damage, confusion, fever, agitation, hallucination, incoordination, tremors, hyperreflexes, diaphoresis high bp, usually 24hrs of starting or st johns wort

contraindication for SSRIs

MAOIs, children under 7

Top 7 for Benzodiazepines

physical dependence and withdrawal, flumazenil, anticholinergic se, cns depression, memory problems no olds, paradox anxiety, teratogenic

Top 5 for SSRIs

suicide, serotonin, weight and sex, anticholingergic, dont stop fast

SNRI prototype

duloxetine/cymbalta

SNRI common syllables

pram, ine

therapeutic indication for SNRIs

antidepressant nri

pharmacokinetics of SNRI

presynaptic, blocks reuptake of serotonin and norepi

blocks dope sorta

side effects/adv effects of snri

serotonin, anorexia, hypertension, insomnia, hyponatremia, tachycardia, tinnitus, vertigo

SNRI need to be dose wayyy _____ bed

before

SNRI top 5(6)

suicide, serotonin, weight and sex, anticholingergic, dont stop fast, cv dysrhythmias

Other antidepressant prototype

buproprion/wellbutrin

bupropion therapeutic indication

antidepressants butrin

bupropion pharmacokinetics

blocks reuptake of serotonin, norepi and dope

why does bupropion work (we think)?

increase availability of dope

bupropion is effective at ______ at low doses

smoking cessation

bupropion top 5

suicide, smoking cessation, seizure hx, cv dysrythmias, cns depression

Because SSRI and SNRI work on the ____ neuron, they are ____ an agonist or antagonist

pre, not

Antidepressants

ssri, snri, bupropion

Anxiolytic (for anxiety)

benzos