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Olfaction
Detection of airborne chemical stimuli called odorants that are encoded into electrical signals
Olfactory epithelium
Odorants interact with olfactory receptor neurons (ORNs) found in an epithelial sheet, the___ ___
The transduction of olfactory information that results in the conscious sense of smell begins here
→ Sheet of neurons and supporting cells that lines approximately half of the surface of the nasal cavity
olfactory bulb
Axons project through the cribriform plate directly to neurons in the ___ ___
Olfactory Tract
The olfactory bulb sends projections to the pyriform cortex and other forebrain structures via the ____ ___
thalamic relay
Unique among the sensory systems, the olfactory system does not include a ___ ___ from primary receptors to the cortical region that processes the sensory information
anosmia
The inability to detect one or more odors
Respiratory epithelium
Lines the remaining surface of the nasal cavity
• Maintains appropriate temperature and moisture for inhaled air
• Provides an immune barrier that protects the nasal cavity from irritation and infection
Mucus layer
• Secreted by Bowman’s glands
• Contains enzymes and antibodies to protect exposed portions of cells to avoid passing infection to brain
• Controls ionic milieu for olfactory cilia
• When thickens → significantly
Olfactory receptor neurons (ORNs)
• Bipolar with unmyelinated axons
• Apical surface → knob that extends olfactory cilia into mucus layer
Olfactory cilia
The primary site of odorant transduction
Basal cells
The stem cells of the adult olfactory epithelium
Sustentacular (supporting) cells
detoxify potentially dangerous chemicals
Olfactory Neurogenesis
Because olfactory receptor neurons are particularly exposed, they are:
a) protected by mucus and b) continuously regenerated
The olfactory epithelium contains stem cells (in the layer of basal cells) that regenerate olfactory neurons throughout life
olfactory nerve
Olfactory receptor neuron axons form a large # of bundles that together make up the ___ ___ (cranial nerve I)
Glomeruli
__ in the olfactory bulb are the synaptic target of the primary olfactory axons
→ Individual ___ respond to different odorants and concentration of odor increases their activity
mitral cells
Within the glomeruli, ORN axons contact apical dendrites of ___ ___
→ Excitatory glutamatergic synapses
These cells are the principal projection neurons of the olfactory bulb
Granule cells
These cells synapse primarily on basal dendrites of mitral cells
→ Establish local inhibitory circuits and participate in synaptic plasticity
Glomerular layer
Layer of the Olfactory Bulb that contains:
– Dendritic tufts of mitral cells
– ORN axon terminals
– Periglomerular cells that define the margins of the glomerulus
External plexiform layer
Layer of the Olfactory Bulb that contains:
– Lateral dendrites of mitral cells
– Cell bodies and lateral dendrites of tufted cells
– Dendrites of granule cells that make dendrodendritic synapses with the other dendritic elements
Mitral cell layer
Layer of the Olfactory Bulb that contains:
– Cell bodies of mitral cells
Internal plexiform layer
Layer of the Olfactory Bulb that contains:
– Mitral cell axons
Granule cell layer
Layer of the Olfactory Bulb that contains:
– Granule cell bodies
pyriform cortex
Main target of mitral cell projections → neurons show broad responses and may integrate different odors (function is unclear)
This area projects to higher areas
orbitofrontal cortex
A higher area of the brain responsible for reward processing
Receives projections from the pyriform cortex
amygdala
A higher area that is responsible for emotional salience and memory
Receives projections from the pyriform cortex
vomeronasal system
The second division of the olfactory system present in carnivores and rodents
The primary function of this system is to encode and process info about odorants (such as pheromones or kairomones) and bring about sexual, reproductive, homeostatic, and/or aggressive responses.
Pheromones
Chemical signals released by an animal and used for communication within a species (conspecifics)
Kairomones
Chemical signals released by an animal and used for communication between species (Predator or prey)
The gustatory system
The system responsible for taste
papillae
3 types → Fungiform, Foliate, and Circumvallate
Human Taste Nerves
Axons run in cranial nerve VII, cranial nerve IX, and cranial nerve X
nucleus of solitary tract
Cranial nerves project to __ ___ ___ ___ (gustatory nucleus)
Taste cells
__ ___ are clustered in taste buds
taste pore
Taste cells are clustered around a __ ___
basal cells
Taste cells are regenerated every 2 weeks from ___ ___, similar to ORNs
5 tastes
Sour, bitter, salty, sweet, and MSG (umami (savory))
salty and sour
____ tastes are elicited by ionic stimuli like positively charged ions in salts (Na+ ) or protons in acids (H+ )
→ Ion channels
Sweet and savory
These taste receptors are G-protein-coupled receptors to PLC IP3 signaling opening TRP channels
Bitter
This taste receptors are also G-protein-coupled receptors with a specific G-protein called gustducin (role remains unclear)
Flehmen response
When animals open their mouth to take in pheromones