MICR3320 L12: Persistent Virus Infection 9/16/24 P7/28

What are the four general patterns of infection?

1) Acute
2) Latent
3) Persistent Asymptomatic
4) Persistent Pathogenic

What pattern of infection is this?

-Rhinovirus
-Rotavirus
-Influenza

Acute

What pattern of infection is this?

-Acute

-Rhinovirus
-Rotavirus
-Influenzavirus

What pattern of infection is this?

-Herpes simplex virus

Latent

What pattern of infection is this?

-Latent

Herpes simplex virus

What pattern of infection is this?

-JC virus
-Lymphocytic choriomeningitis virus

Persistent: Asymptomatic

What pattern of infection is this?

-Persistent: Asymptomatic

-JC virus
-Lymphocytic choriomeningitis virus

What pattern of infection is this?

-HIV
-HTLV (Human T cell Lymphocytic Virus)
-Measles virus

Persistent: Pathogenic

What pattern of infection is this?

-Persistent: Pathogenic

-HIV
-HTLV
-Measles virus

What is this?

-Virus, genomes, fragments persist in host longterm
-Months, years, duration of lifetime
-Chronic and latent

Persistent infections

What type of persistent infection is this?

-Lytic replication in multicellular organism
-Low levels, longer than cell division cycle
-Immune system takes a while to eliminate the virus

Chronic

What type of persistent infection is this?

-Virus exits lytic cycle
-Persists in nucleic acids/proteins
-No new virions are produced
-Viral proteins not detectable
-Reenters lytic cycle when host is stressed

Latent

What are some subfamilies of Herpesviruses?

Alpha, beta, gamma

What is this?

-HSV 1, HSV 2

Latent herpesviruses

Where do latent herpesviruses like HSV-1 and HSV-1 establish latent infection?

Lytic infection of epithelium