BIOC E Note

Helix

________ 4 has a high net positive charge, and is sensitive to membrane voltage.

Loss of energy

________ is required to pass to the other side and regain the hydration sphere.

Proteins

________ are tethered in aggregates or patches.

H2O

When liquid, water is ________, sometimes these protons dissociate and jump from water to water.

Detergent

________ releases a membrane protein= INTEGRAL.

Phosphatidylcholine

________ is a major lipid in all membranes.

Bacterial

________ and mitochondrial outer membrane proteins are B- barrels.

Farnesylation

________= addition of an isoprenoid to the c terminal of a cysteine residue.

Cholesterol

________ allows efficient packing of kinked chains.

PH

________ or chelator releases a membrane protein= PERIPHERAL.

Lipids

________ behave as through they are corralled by fences, which they occasionally escape.

relaxes

When membrane is depolarized helix 4 ________, and moves towards outside.

GLUT1

________= Uniporter, only glucose and based on the concentration gradient, not in any one direction.

Bacteriorhodopsin

multispanning transmembrane

Unsaturated, cis fatty acids

decrease fluidity

High temperatures

decrease fluidity

Low temperatures

increases fluidity

Can be gated

open and close in response to stimuli

Na+ channels, K+ channels, Cl

channels, H2O channels

tetramer

each subunit contains 2 transmembrane helices, a shorter helix and a selectivity filter connecting the short helix to one of the long filters

Passive transporter operation

GLUT1

Many are powered by ATP hydrolysis

ion pumping ATPase

Na+ K+ ATPase

an ion-pumping ATPase