Unit 3: Anatomy Lecture Slides (work in progress)

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cranial nerves and hormones on matching questions, which are half of test put hormones on card primary sensory areas

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1

Introduction to the Nervous System [ch 13: Nervous System: Nervous Tissue]

• The nervous system controls & adjusts the body’s activities
• provides swift but brief responses

• Functions
• sensory: detects changes within & outside body
• integrative: analyzes & stores information; determines appropriate
responses
• motor: responses

• Divisions
• Central Nervous System (CNS)
• brain & spinal cord
• integrates, processes & coordinates sensory input w/ motor output
• seat of intelligence, memory, learning & emotion
• Peripheral Nervous System (PNS)
• consists of structures outside of CNS → nerves (inc. roots & branches),
neuromuscular junctions
• provides sensory information to CNS + carries motor commands away from
CNS

<p>• The nervous system controls &amp; adjusts the body’s activities<br>• provides swift but brief responses<br></p><p>• Functions<br>   • sensory: detects changes within &amp; outside body<br>   • integrative: analyzes &amp; stores information; determines appropriate<br>responses<br>   • motor: responses<br></p><p>• Divisions<br>• Central Nervous System (CNS)<br>   • brain &amp; spinal cord<br>   • integrates, processes &amp; coordinates sensory input w/ motor output<br>   • seat of intelligence, memory, learning &amp; emotion<br>• Peripheral Nervous System (PNS)<br>   • consists of structures outside of CNS → nerves (inc. roots &amp; branches),<br>neuromuscular junctions<br>   • provides sensory information to CNS + carries motor commands away from<br>CNS</p>
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Peripheral Nervous System Divisions

• Peripheral nervous system (PNS) divided into:
• Sensory (afferent) division: brings sensory info to CNS
• begins at receptors → categorized as somatic, visceral, special sensory
• Motor (efferent) division: carries out motor commands from CNS
• ends at effectors`
• subdivided into autonomic & somatic nervous systems
• Somatic NS: voluntary; skeletal muscle effectors
• Autonomic: involuntary; glands, smooth & cardiac muscle effectors
• divided into sympathetic (“fight-or-flight”) & parasympathetic (“rest-or-digest”) NS

<p>• Peripheral nervous system (PNS) divided into:<br>   • Sensory (afferent) division: brings sensory info to CNS<br>      • begins at receptors → categorized as somatic, visceral, special sensory<br>• Motor (efferent) division: carries out motor commands from CNS<br>   • ends at effectors`<br>   • subdivided into autonomic &amp; somatic nervous systems<br>      • Somatic NS: voluntary; skeletal muscle effectors<br>      • Autonomic: involuntary; glands, smooth &amp; cardiac muscle effectors<br><span style="color: transparent">• divided into sympathetic (“fight-or-flight”) &amp; parasympathetic (“rest-or-digest”) NS</span></p>
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Nervous Tissue: Cells

• Nervous tissue consists of two cell types:
• neurons
• responsible for transfer & processing of information
• consists of a soma (cell body), axon, dendrites, and axon terminals

• neuroglia (brain tumors)
• supporting cells; maintain homeostasis
• mitotically active → can lead to gliomas
• protect the neuron

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CNS Neuroglia ***

• Astrocytes
• largest & most numerous
• has multiple processes
• involved in neurotransmitter metabolism
• comprises the blood-brain barrier
• imp’t for brain dev’t
link bet. neuron & blood vessels → nutrition &
metabolism

• Microglia
• small phagocytic cells
• derived from
monocytes

• Ependymal cells
• make up the ependyma: lines brain
ventricles & spinal cord central canal

produces
cerebrospinal fluid
(CSF)

• squamous to columnar epithelia w/ cilia

• Oligodendrocytes
• forms a support network for neurons (has branches)
• produce myelin sheaths for
portions of up to 15 neurons

<p><mark data-color="blue">• Astrocytes</mark><br>• largest &amp; most numerous<br>• has <u>multiple processes</u><br>• involved in <strong>neurotransmitter metabolism</strong><br>• comprises the <strong><u>blood-brain barrier</u></strong><br>• imp’t for <u>brain dev’t</u><br>• <u>link bet. neuron &amp; blood vessels</u> → nutrition &amp;<br>metabolism</p><p></p><p><mark data-color="blue">• Microglia</mark><br>• small <u>phagocytic cells</u><br>• derived from<br>monocytes<br></p><p><mark data-color="blue">• Ependymal cells</mark><br>• make up the <strong>ependyma:</strong> lines <u>brain<br>ventricles &amp; spinal cord central canal</u><br>• <u>produces<br></u><strong><u>cerebrospinal fluid<br>(CSF)</u></strong><br>• squamous to columnar epithelia w/ cilia</p><p><mark data-color="blue">• Oligodendrocytes</mark><br>• forms a support network for neurons (has branches)<br>• produce myelin sheaths for<br><span style="color: transparent">portions of up to 15 neurons</span></p>
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PNS Neuroglia: Satellite Cells & Schwann Cells

• Satellite cells
• support neurons in PNS
ganglia
• wrapped around neuronal
cell bodies

• Schwann cells: aka neurolemmocytes (pancakes that wrap themselves around ONE axon)
• myelinate PNS axons
• 1 myelin sheath around a
portion of 1 PNS neuron

<p><mark data-color="blue">• Satellite cells</mark><br>• support neurons in PNS<br>ganglia<br>• wrapped around neuronal<br>cell bodies<br></p><p><mark data-color="blue">• Schwann cells</mark>: aka neurolemmocytes (pancakes that wrap themselves around ONE axon)<br>• myelinate PNS axons<br>• 1 myelin sheath around a<br><span style="color: transparent">portion of 1 PNS neuron</span></p>
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Neurons: Structure

• cell body (soma): processes information; contains...
• perikaryon: cytoplasm
• neurofilaments/neurotubules: cytoskeleton
• neurofibrils: bundles of neurofilaments
• Nissl bodies: clusters of rough ER → chromatophilic substance
• dendrites: highly branched processes; receiving (input) portion

<p><strong>• cell body (soma)</strong>: processes information; contains...<br>   <strong>• perikaryon:</strong> cytoplasm<br>   • neurofilaments/neurotubules: cytoskeleton<br>      <strong>• neurofibrils: </strong>bundles of neurofilaments<br>   <strong>• Nissl bodies:</strong> clusters of rough ER → chromatophilic substance<br><strong>• dendrites:</strong> highly branched processes; receiving (input) portion</p>
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Neurons: Structure

• axon: long, cylindrical projection; transmitting portion → transmits
nerve impulses to target cell; contains...
axoplasm & axolemma: cytoplasm & cell membrane
axon hillock: cell body-axonal junction → site of action potential generation
axoplasmic transport: movement of material bet. cell body & axon
collaterals: branches off the axon
telodendria: ends of axon & collaterals
axon terminals: ends of telodendrias
synaptic end bulbs: contain synaptic vesicles w/ neurotransmitters

• Axons typically myelinated
myelin: insulative covering
• increases speed of action potential conduction
node of Ranvier: gaps in myelin sheath

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Neurons: Classification****


Neurons can be classified based on:
structure: # of processes extending from cell body
function: sensory, motor, or interneuron

• Structural Classifications
anaxonic: many processes, but axons & dendrites indistinguishable
• only in CNS
multipolar: multiple dendrites, 1 axon
• most brain & spinal cord neurons
• bipolar: 1 dendrite, 1 unmyelinated axon
• retina, inner ear, olfactory areas of brain
pseudounipolar: cell body off to side; 1 process, but distinctly separates into dendrite & axon

WE WILL GET THIS PICTURE AND WILL HAVE TO IDENTIFY WHICH NEURON IS WHICH**********

<p><br>Neurons can be classified based on:<br>   • <strong>structure:</strong> # of processes extending from cell body<br>   • <strong>function:</strong> sensory, motor, or interneuron<br></p><p><strong>• Structural Classifications</strong><br>•<strong> anaxonic:</strong> many processes, but axons &amp; dendrites indistinguishable<br>   • only in CNS<br>•<strong> multipolar:</strong> multiple dendrites, 1 axon<br>   • most brain &amp; spinal cord neurons<br><strong>• bipolar:</strong> 1 dendrite, 1 unmyelinated axon<br>   • retina, inner ear, olfactory areas of brain<br>•<strong> pseudounipolar: </strong>cell body off to side; 1 process, but distinctly separates into dendrite &amp; axon</p><p></p><p>WE WILL GET THIS PICTURE AND WILL HAVE TO IDENTIFY WHICH NEURON IS WHICH**********</p>
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Neurons Classification

• Functional Classifications
sensory (afferent): transmit from receptors (PNS) → CNS
motor (efferent): transmit from CNS → effectors (PNS)
interneurons (association neurons): analyze sensory input & coordinate
motor outputs; located entirely in CNS, bet. motor & sensory neurons
• most neurons in body (~90%)
• can be excitatory or inhibitory

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Nervous System Terminology***

nerve fiber: any neuronal process → primarily the axon

nerve: bundle of many fascicles → comprised of
many nerve fibers that course along the same path in PNS
• includes both sensory & motor fibers surrounded by CT = endo-, peri- & epi- neurium

ganglion (pl. ganglia): cluster of nerve cell bodies in PNS

tract: bundle of nerve fibers in CNS

nucleus: cluster of nerve cell bodies in CNS

white matter: myelinated axons

grey matter: unmyelinated fibers (dendrites & axons) and cell bodies

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Neuron Organization and Processing***

• Recall: Neurons connect w/ other neurons or effectors via synapses
presynaptic neuron: conducts impulses toward a synapse
postsynaptic neuron: receives impulses & conducts them away from a synapse

• Neurons can be organized into smaller organized groups called neuronal pools → identified by their neural circuits
• Divergence
• Convergence
• Serial processing
• Parallel processing
• Reverberation

<p>• Recall: Neurons connect w/ other neurons or effectors via <strong>synapses</strong><br>   • <strong>presynaptic neuron:</strong> conducts impulses toward a synapse<br>   •<strong> postsynaptic neuron:</strong> receives impulses &amp; conducts them away from a synapse<br></p><p>• Neurons can be organized into smaller organized groups called <strong>neuronal pools</strong> → identified by their <strong>neural circuits</strong><br>• Divergence<br>• Convergence<br>• Serial processing<br>• Parallel processing<br>• Reverberation</p>
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<p>Neural Circuits: Types****</p>

Neural Circuits: Types****

Divergence: 1 presynaptic neuron → many postsynaptic neurons
• permits broad distribution of a specific input
• info enters CNS → spreads to brain & spinal cord simultaneously

Convergence: many presynaptic neurons → 1 postsynaptic neuron

Serial processing: 1 presynaptic → 1 postsynaptic in a sequence
• info from 1 part of the brain goes to the next part then another part, etc.

Parallel processing: 1 neuron → many neurons → 1 neurons
• several neurons process the info at the same time
• e.g. If you step on a nail, you typically move your foot, shout “ouch,”
and dance a bit, all at the same time

Reverberation: positive feedback arrangement
• collateral axons extend back toward origin of impulse → impulse
continued and/or enhanced

ON TEST THIS IS A FILL IN THE BLANK USING PICTURES************

<p><mark data-color="blue">• </mark><strong><mark data-color="blue">Divergence:</mark></strong><mark data-color="blue"> </mark>1 presynaptic neuron → many postsynaptic neurons<br>• permits broad distribution of a specific input<br>• info enters CNS → spreads to brain &amp; spinal cord simultaneously<br></p><p><mark data-color="blue">• </mark><strong><mark data-color="blue">Convergence:</mark></strong> many presynaptic neurons → 1 postsynaptic neuron<br></p><p><mark data-color="blue">• </mark><strong><mark data-color="blue">Serial processing:</mark></strong> 1 presynaptic → 1 postsynaptic in a sequence<br>• info from 1 part of the brain goes to the next part then another part, etc.<br></p><p><mark data-color="blue">• </mark><strong><mark data-color="blue">Parallel processing:</mark></strong><mark data-color="blue"> </mark>1 neuron → many neurons → 1 neurons<br>• several neurons process the info at the same time<br>• e.g. If you step on a nail, you typically move your foot, shout “ouch,”<br>and dance a bit, all at the same time<br></p><p><mark data-color="blue">• </mark><strong><mark data-color="blue">Reverberation: </mark></strong>positive feedback arrangement<br>• collateral axons extend back toward origin of impulse → impulse<br>continued and/or enhanced</p><p></p><p>ON TEST THIS IS A FILL IN THE BLANK USING PICTURES************</p>
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Regeneration of Nervous Tissue***

• Neurons have limited ability for regeneration
• CNS
• little to no repair
Neuroglia inhibit axonal regrowth
Astrocytes proliferate rapidly following injury →
scar tissue develops = physical barrier to regrowth

• PNS****
• Intact cell body & active Schwann cells required
for repair/regrowth to occur
• Wallerian degeneration: repair mechanism (nerves) in PNS
• S1: axon distal to injury site deteriorates
• S2: macrophages phagocytize debris
• S3: Schwann cells divide → form solid cord that
follows original axon path
• S4: Schwann cells release axonal growth factors
• cut axons: regrowth in hours
• crushed/torn axons: 1 or more weeks

Motorcyclist injures nerve in leg, why doesn’t it repair itself? Cell body not in tact & no active Shwann cells. PNS is for legs and has nerves

<p>• Neurons have limited ability for regeneration<br><strong><u>• CNS</u></strong><br>• little to no repair<br>• <strong>Neuroglia</strong> inhibit axonal regrowth<br>• <strong><u>Astrocytes</u> </strong>proliferate rapidly following injury →<br><strong>scar tissue</strong> develops = <u>physical barrier</u> to regrowth<br></p><p><strong><u>• PNS****</u></strong><br>• Intact <strong>cell body</strong> &amp;<u> active </u><strong>Schwann cells </strong>required<br>for repair/regrowth to occur<br><mark data-color="blue"> </mark><strong><u><mark data-color="blue">• Wallerian degeneration: </mark></u></strong>repair mechanism (nerves) in PNS<br>• S1: <strong>axon </strong>distal to injury site deteriorates<br>• S2: <strong>macrophages<u> </u></strong><u>phagocytize </u>debris<br>• S3:<strong> Schwann cells divide</strong> → form solid cord that<br>follows original axon path<br>• S4: Schwann cells release <u>axonal growth factors</u><br>• cut axons: regrowth in hours<br>• crushed/torn axons: 1 or more weeks</p><p></p><p>Motorcyclist injures nerve in leg, why doesn’t it repair itself? Cell body not in tact &amp; no active Shwann cells. PNS is for legs and has nerves</p>
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Introduction to the Central Nervous System

• Central Nervous System (CNS) consists of:

• brain & spinal cord
• integrates & processes information
• can function w/ one another and independently of each other
• Spinal cord anatomy
• vertebral column: forms the canal
• meninges: connective tissue coverings that encircle spinal cord & brain
cerebrospinal fluid

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Gross External Anatomy of the Spinal Cord

• Spinal cord has 31 spinal segments; each segment has:
• dorsal roots
• dorsal root ganglia
• ventral root

spinal nerve: mixed nerves consisting of afferent & efferent fibers
posterior median sulcus: shallow,
longitudinal groove on posterior surface
anterior median fissure: deep crease on anterior surface

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Spinal Meninges***

Spinal meninges: specialized membranes for protection, physical stability & shock absorption
• continuous w/ cranial meninges

• 3 layers
dura mater: tough, fibrous outermost layer
arachnoid mater: middle layer
pia mater: innermost layer (adjacent to spinal or brain tissue)

<p>• <mark data-color="blue">Spinal meninges: </mark>specialized membranes for protection, physical stability &amp; shock absorption<br>   • continuous w/ cranial meninges<br></p><p>• 3 layers<br>• <mark data-color="blue">dura mater:</mark> tough, fibrous outermost layer<br>• <mark data-color="blue">arachnoid mater:</mark> middle layer<br>• <mark data-color="blue">pia mater:</mark> innermost layer (adjacent to spinal or brain tissue)</p>
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Dura Mater & Arachnoid Mater: Spinal Meninges***

• Dura mater: superficial layer of dense irregular CT
• stabilizes spinal cord w/in vertebral canal
• cranial & sacral attachments stabilize longitudinal axis of spinal cord
forms a sac from level of foramen magnum to 2 nd sacral vertebra
• fat & CT lie in epidural space bet. dura mater & vertebral canal
blends w/ filum terminale to form coccygeal ligament

• Arachnoid Mater: avascular middle layer of collagen & elastic fibers
continuous w/ brain’s arachnoid mater
• separated from pia mater by subarachnoid space
• contains cerebrospinal fluid
subdural space: bet. dura mater & deeper meninges
• contains interstitial fluid
only in CADAVERS; not in living people

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Pia Mater: Spinal Meninges***

• Pia mater: vascular deepest layer of collagen & elastic fibers
firmly attached to brain & spinal cord tissue
• denticulate ligaments: membranous extensions of pia mater that attach
pia mater & arachnoid mater to dura mater

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Sectional Anatomy of the Spinal Cord

Gray matter: H-shaped region of neuronal cell
bodies, neuroglia, unmyelinated axons & dendrites
• surrounds a central canal → extends entire length of spinal cord
• central canal continuous w/ 4 th ventricle of brain
• called horns due to their shape

• White matter: consists primarily of myelinated axons
(some unmyelinated)
• axons organized into tracts or columns
• located outside gray matter area

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Sectional Anatomy: Organization of Gray Matter

• Cell bodies organized into nuclei (sensory & motor)
Gray commissures***: connect right & left sides
• consists of axons crossing from 1 side to the other

• Horns
posterior (dorsal) horns: sensory somatic & visceral nuclei
lateral (intermediate) horns: visceral motor nuclei
anterior (ventral) horns: somatic motor nuclei

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Spinal Cord Tracts (c15)***

• Gray matter receives & integrates information
White matter tracts conduct the nerve impulses
• Communication involves sensory & motor tracts
ascending tract: sensory (delivers info to brain)
descending tract: motor (delivers info to periphery)
• All tracts involve both brain & spinal cord

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Somatosensory Tracts: Spinal Cord Tracts (c15)***

3 major (somato) sensory tracts: ASCENDING tracts

  • SPINOTHALAMIC (STT): pain, temp, crude touch, deep pressure

  • POSTERIOR COLUMN: proprioception (body position), 2-point discrimination (fine touch), vibration

    • gracile fasciculus (fasciculus gracilis): transmits info to cerebrum from
      areas inferior to T6
      cuneate fasciculus (fasciculus cuneatus): transmits info to cerebrum from
      areas superior to T6

  • SPINOCEREBELLAR (SCT): proprioception

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Motor Tracts: Spinal Cord Tracts (c15)

2 major motor tracts: DESCENDING tracts

Pyramidal: originate in cerebral cortex, transmits to spinal cord
• precise voluntary movements

Extrapyramidal (subconscious motor): originate in brain stem, transmits to spinal cord

involuntary & automatic control of musculature = skeletal muscle tone,
balance, posture, locomotion, equilibrium

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Spinal Nerves: Organization***

• Each peripheral nerve consists of:
epineurium: outer layer; fuses w/ dura mater as nerve exits through
intervertebral foramen
perineurium: surrounds each fascicle (bundle of axons)
endoneurium: layer surrounding each axon

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Peripheral Distribution of Spinal Nerves***

Rami communicantes: 2 additional branches on spinal nerves T 1 → L2 that
carry visceral motor fibers to & from nearby autonomic ganglia
white ramus communicans
gray ramus communicans
• associated w/ sympathetic division of autonomic nervous system

Dermatomes: area of skin that provides sensory input to posterior roots of 1
pair of spinal nerves or to 1 spinal cord segment
• adjacent dermatomes may overlap

<p>• <mark data-color="blue">Rami communicantes:</mark> 2 additional branches on spinal nerves T 1 → L2 that<br>carry visceral motor fibers to &amp; from nearby<strong> autonomic ganglia</strong><br>•<strong> white ramus communicans</strong><br>•<strong> gray ramus communicans</strong><br>• associated w/ <strong>sympathetic division</strong> of autonomic nervous system</p><p>•<mark data-color="blue"> Dermatomes: </mark>area of skin that provides <u>sensory input</u> to posterior roots of 1<br>pair of spinal nerves or to 1 spinal cord segment<br>• adjacent dermatomes may overlap</p>
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Nerve Plexuses

• Nerve plexus: interwoven network of nerves formed from
all adjacent ventral rami (except T2 → T12 )

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Embryology of the Brain [ch16: The Brain]

• The CNS begins as a hollow neural tube w/ a fluid-filled lumen
(neurocoel)
• Neurocoel expands & forms the brain’s various ventricles

• 4 th wk of dev’t: 3 primary brain vesicles form in the neural tube:
prosencephalon: forebrain
mesencephalon: midbrain
rhombencephalon: hindbrain

• 6 th wk of dev’t: prosencephalon & rhombencephalon subdivide
• prosencephalon
• diencephalon: thalamus & hypothalamus
• telencephalon: cerebrum
• mesencephalon: does not divide
• rhombencephalon
• myelencephalon: medulla oblongata
• metencephalon: pons & cerebellum

Know how to diagram this out***

<p>• The CNS begins as a hollow neural tube w/ a fluid-filled lumen<br><strong>(neurocoel)</strong><br>• Neurocoel expands &amp; forms the brain’s various<strong> ventricles</strong><br></p><p>• 4 th wk of dev’t: <strong>3 primary brain vesicles</strong> form in the neural tube:<br>•<mark data-color="blue"> prosencephalon: </mark>forebrain<br>•<mark data-color="blue"> mesencephalon: </mark>midbrain<br>•<mark data-color="blue"> rhombencephalon:</mark> hindbrain</p><p></p><p>• 6 th wk of dev’t: <strong>prosencephalon &amp; rhombencephalon </strong>subdivide<br><strong>• prosencephalon</strong><br><strong>• diencephalon:</strong> thalamus &amp; hypothalamus<br><strong>• telencephalon: </strong>cerebrum<br><strong>• mesencephalon: </strong>does not divide<br><strong>• rhombencephalon</strong><br><strong>• myelencephalon: </strong>medulla oblongata<br><strong>• metencephalon: </strong>pons &amp; cerebellum</p><p></p><p>Know how to diagram this out***</p>
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Cerebrum

conscious
thought & intellectual
functions; memory;
conscious regulation of
skeletal muscle contractions
• paired cerebral
hemispheres separated by
longitudinal fissure
• Contains sulci (grooves) &
gyri (ridges)

Cerebellum

coordinates
somatic motor function;
adjusts output of somatic
motor centers  smooth
operation

Midbrain

(midbrain): processes visual & auditory data;
maintains consciousness & alertness; reflexive somatic motor
responses to stimuli

Medulla Oblongata

relays info to thalamus & brainstem;
regulates heart rate, blood pressure & digestion

Pons

relays info to cerebellum & thalamus; regulates somatic
& visceral motor centers

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Protection and Support of the Brain: Cranial Meninges***

• Meninges surround brain & spinal cord; 3 layers

• dura mater: most superficial; 2 layers
• thicker, outer periosteal layer –
attached to cranial bones
• thinner, inner meningeal layer
• extensions of dura mater
• falx cerebri: separates cerebral
hemispheres
• falx cerebelli: separates
cerebellar hemispheres
• tentorium cerebelli: separates
cerebellum from cerebrum’s
occipital lobes
• diaphragma sellae: lines sphenoid’s sella turcica

• arachnoid mater: middle layer

• pia mater: deepest layer

<p>• Meninges surround brain &amp; spinal cord; 3 layers<br></p><p><mark data-color="blue">• dura mater: </mark>most superficial; 2 layers<br>• thicker, <u>outer </u><strong><u>periosteal </u></strong>layer –<br>attached to cranial bones<br>• thinner,<u> inner </u><strong><u>meningeal </u></strong>layer<br>• extensions of dura mater<br><strong>   • falx cerebri: </strong>separates cerebral<br>hemispheres<br><strong>   • falx cerebelli: </strong>separates<br>cerebellar hemispheres<br> <strong>  • tentorium cerebelli: </strong>separates<br>cerebellum from cerebrum’s<br>occipital lobes<br><strong>   • diaphragma sellae: </strong>lines sphenoid’s sella turcica<br></p><p><mark data-color="blue">• arachnoid mater:</mark> middle layer<br></p><p><mark data-color="blue">• pia mater: </mark>deepest layer</p>
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Protection and Support of the Brain: Cerebrospinal Fluid***

• Cerebrospinal fluid (CSF): provides support for the brain
• located in subarachnoid space & brain ventricles
2 lateral ventricles (1 st & 2nd): cerebrum
3rd ventricle: vertical midline slit inferior to thalamus
4th ventricle: bet. brainstem & cerebellum

• Functions of CSF
mechanical protection: floats the brain
chemical protection: optimal for neuronal signaling
circulation: medium for exchange

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Formation & Circulation: Cerebrospinal Fluid***

• Formation of CSF
• produced by ependymal cells covering the choroid plexus
(capillary networks in ventricle walls)

• Circulation of CSF
• S1: CSF made in choroid plexus of lateral ventricles flows into 3 rd
ventricle
via interventricular foramen
• S2: 3 rd ventricle adds CSF → flows through cerebral aqueduct,
passing through midbrain & into 4th ventricle
• S3: 4 th ventricle adds more CSF → flows into subarachnoid space
via 1 median & 2 lateral apertures of 4 th ventricle
• S4: CSF reabsorbed through arachnoid granulations &
superior sagittal sinus
into cerebral veins

• Most CSF flows into subarachnoid space w/ some flowing into
spinal cord’s central canal

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Rhombencephalon » Myelencephalon = Medulla Oblongata

Medulla oblongata: continuous w/ spinal cord
• bet. foramen magnum & pons
pathway for communication: contains all ascending & descending
tracts that relay info bet. brain & spinal cord

• Pyramids in the medulla oblongata
• found on ventral side → contains largest motor tracts from cerebral
cortex → spinal cord
• cross at decussation of pyramids*** (responsible for contralateral control of body)
• fibers end in anterior gray horns & synapse w/ skeletal muscle motor
neurons

• Olives: lateral bulges → control precise voluntary movements
& pressure

• Autonomic nuclei = reflex centers: receive input from cranial
nerves, cerebral cortex, diencephalon & brain stem

cardiovascular centers (cardiac & vasomotor)
respiratory rhythmicity centers (rhythmic breathing)

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Rhombencephalon » Metencephalon = Pons***

• Pons: prominent bulge superior to
medulla oblongata & anterior to
cerebellum
• consists of nuclei & tracts
• acts as bridge bet. spinal cord &
brain + diff. parts of brain

• nuclei involved w/ involuntary control
of breathing
• pneumotaxic (inhibition) &
apneustic (prolonged inspiration)
centers

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Reticular Formation: Brain Stem

• Reticular formation: interconnected nuclei w/in brainstem; extends into spinal cord & diencephalon
• small areas of gray matter separated by white fibers

• SENSORY function
reticular activating system (RAS)***: relays info to cortex
• responsible for consciousness & awakening

MOTOR function
• major relay center for muscle tone

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Mesencephalon » Midbrain: Brain Stem

• Mesencephalon: bet. pons & diencephalon (hypothalamus)
Tectum: aka roof; surface posterior to cerebral aqueduct
• contains corpora quadrigemina***: 2 pairs of sensory nuclei responsible for
processing auditory & visual stimuli

substantia nigra***: regulates motor output of basal nuclei → subconscious
muscle activities → releases dopamine
(inhibitory neural transmitter that stops muscle contraction) [dopamine counteracts serotonin (excitatory: contracts muscles)]

  • Parkinson’s disease: there is no dopamine b/c substantia nigra is destroyed

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Prosencephalon » Diencephalon: Introduction***

• The diencephalon consists of:
• epithalamus: superior to thalamus
• contains pineal gland*** → makes melatonin → regulates day/night cycles (and stops gametes from maturing)
• forms roof of diencephalon

thalamus: paired structures above midbrain; 80% of diencephalon

hypothalamus: inferior to thalamus
infundibulum***: connects hypothalamus to pituitary gland
• forms floor & parts of lateral walls of 3rd ventricle

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Prosencephalon » Diencephalon

• epithalamus: superior to thalamus
• contains pineal gland → makes melatonin → regulates day/night cycles
• forms roof of diencephalon

• hypothalamus: inferior to thalamus
• infundibulum: connects hypothalamus to pituitary gland
• forms floor & parts of lateral walls of 3rd ventricle

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Prosencephalon » Diencephalon: Hypothalamus************************

• Functions of the hypothalamus
• controls & integrates voluntary & autonomic NS activities
• regulates:
• body temperature (pre-optic area)
• food intake/digestive functions,
• waking state & sleep patterns (aka circadian rhythms - suprachiasmatic
nucleus)

• heart rate
• blood pressure
• respiration
• acts as a thirst center
• part of the limbic system: emotions (rage & aggression)
• secretes hormones (ADH - supraoptic nucleus & oxytocin –
paraventricular nucleus)

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Rhombencephalon » Metencephalon: Cerebellum

• Cerebellum
• posterior to medulla & pons; inferior to occipital lobe of cerebrum
• separated from cerebrum by tentorium cerebelli
• 2 cerebellar hemispheres

cerebellar nuclei & cortex: subconscious coordination of movements
arbor vitae: “tree of life;” branching array of white matter in internal
portion; connects cerebellar cortex & nuclei w/ cerebellar peduncles

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Rhombencephalon » Metencephalon: Cerebellum***

• Cerebellum
coordinates your semantic motor function based on learned patterns of movement

• Functions*
• regulating posture & balance
programming + fine-tuning of voluntary & involuntary movements

• Information Relay*
• Cerebellum receives sensory input from proprioceptors in muscles,
joints, etc.
• Cerebellum detects variations & sends feedback to motor areas
• has no direct connections w/ skeletal muscles

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Prosencephalon » Telencephalon: Cerebrum - Structures & Lobes***

• Cerebrum
• 2 hemispheres separated by longitudinal fissure
• several lobes
frontal: conscious control of skeletal muscles
central sulcus: separates frontal from parietal
precentral gyrus: anterior to central sulcus = primary motor area
parietal: conscious perception of touch, pressure, vibration, pain, temperature & taste
postcentral gyrus: primary somatosensory area
parietooccipital sulcus: separates parietal from occipital
temporal: conscious perception of auditory & olfactory stimuli
lateral cerebral sulcus: separates temporal from frontal
insula: deep to temporal lobe; “island” of cortex
occipital: perception of visual stimuli

transverse fissure: separates cerebrum from cerebellum
gyri: elevated ridges
sulci: depressed grooves
corpus callosum: allows left & right hemispheres to communicate w/
each other

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Telencephalon: Cerebrum - Gray & White Matter***

cerebral cortex: outer gray
matter
cerebral white matter:
myelinated axons extending
in 3 directions
association fibers: connect
cortical areas w/in same
hemisphere

commissural fibers:
connect corresponding
lobes of diff. hemisphere
s
(crosses over)
corpus callosum
• anterior commissure
• posterior commissure
projection fibers: form
descending & ascending
tracts
(internal capsule)

<p>• <strong>cerebral cortex:</strong> <u>outer gray</u><br>matter<br>• <strong>cerebral white matter:</strong><br><u>myelinated axons </u>extending<br>in 3 directions<br>• <strong>association</strong> fibers: connect<br>cortical areas w/in <u>same<br>hemisphere</u><br>• <strong>commissural</strong> fibers:<br>connect <u>corresponding<br>lobes of diff. hemisphere</u>s<br>(crosses over)<br>   • <strong><u>corpus callosum</u></strong><br>   • anterior commissure<br>   • posterior commissure<br>•<strong> projection</strong> fibers: form<br><u>descending &amp; ascending<br>tracts </u>(internal capsule)</p>
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Telencephalon: Cerebrum - Basal Nuclei ***

Basal nuclei: groups of nuclei in each hemisphere
corpus striatum: major input site for basal ganglia
caudate nucleus: controls large automatic movements of skeletal muscles
lentiform nuclei
putamen: lateral; same function as caudate nucleus
globus pallidus: medial; regulation of muscle tone
claustrum: subconscious processing of visual info
amygdaloid body: limbic system

• Functions
• subconscious control & integration of skeletal muscle tone
• coordination of learned movement patterns
• processing, integration & relay of info from cerebral cortex

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Telencephalon: Cerebrum - Limbic System***

• Limbic system: encircles brain stem on inner border of cerebrum &
floor of diencephalon, superior to corpus callosum

• Functions
• establishes emotional states
• memory storage & retrieval
• links conscious functions w/ unconscious autonomic functions

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Telencephalon: Cerebral Cortex Sensory Areas: ONE OF MATCHING QUESTIONS************ worth 10% of test

• Sensory areas: primary vs. secondary & association
• primary areas: have most direct connections w/ peripheral sensory
receptors
• secondary & association areas: receive input from primary areas &
participate in interpretation of sensory info

• Primary somatosensory: postcentral gyrus (parietal lobe)
• nerve impulses for touch, pain, temperature & proprioception
• localize exact points of body where sensations originate

• Primary visual: occipital lobe
• impulses from eye receptors sent to thalamus and then to visual cortex

• Primary auditory: temporal lobe
• basic characteristics of sound (e.g. pitch & rhythm)

• Primary olfactory: temporal lobe
• interprets smell

• Primary gustatory: parietal lobe
• interprets taste

<p><strong>• Sensory areas: </strong>primary vs. secondary &amp; association<br>• primary areas: have most direct connections w/ peripheral sensory<br>receptors<br>• secondary &amp; association areas: receive input from primary areas &amp;<br>participate in interpretation of sensory info<br></p><p><strong>• Primary somatosensory:</strong> postcentral gyrus (parietal lobe)<br>• nerve impulses for touch, pain, temperature &amp; proprioception<br>• localize exact points of body where sensations originate<br></p><p><strong>• Primary visual:</strong> occipital lobe<br>• impulses from eye receptors sent to thalamus and then to visual cortex<br></p><p><strong>• Primary auditory: </strong>temporal lobe<br>• basic characteristics of sound (e.g. pitch &amp; rhythm)<br></p><p><strong>• Primary olfactory:</strong> temporal lobe<br>• interprets smell<br></p><p><strong>• Primary gustatory:</strong> parietal lobe<br>• interprets taste</p>
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Telencephalon: Cerebral Cortex Motor & Language Areas****************

Primary motor cortex: precentral gyrus (frontal lobe)
• voluntary contractions of skeletal muscles

• Language areas: associated w/ left cerebral hemisphere
Broca’s area: aka speech center = motor speech area
• regulates patterns of breathing & vocalization for normal speech
• nerve impulses from Broca’s area sent to premotor regions → control
muscles of larynx, pharynx & mouth
• impulses to primary motor area regulate breathing

Wernicke’s area: analytical center = language comprehension
• inferior to auditory cortex in temporal lobe
• interprets sound as speech, music, or tone
• translates words/sounds into thoughts
• plays role in personality → integrates sensory info & coordinates access to
visual & auditory memories

auditory association area***

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Telencephalon: Association Areas***

Association areas: associated w/ integrating & understanding sensory or motor info (cause and effect, decision making)
Prefrontal association area (frontal lobe)
• integrates info from sensory association areas & predicts consequences
of possible responses
Somatosensory association area (posterior to primary
somatosensory area)
• processes input from thalamus, inferior portions of brain & primary
somatosensory area
• integrates & interprets sensations (inc. storage of memories for
comparison w/ new ones, tactile interpretation of objects → size, form &
texture)
Visual association area (occipital lobe)
• receives input from primary visual cortex & thalamus
• relates past visual experiences w/ present for evaluation

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Telencephalon: Association Areas***

Premotor cortex (immediately anterior to primary motor cortex)
• uses memories of learned movement patterns to coordinate complex &
sequential motor activities
• complicated learning & reasoning functions
Auditory association area (within Wernicke’s area)
• discerns auditory cues as sounds, speech, or music
Gnostic area
• common integrative area → among somatosensory, visual & auditory
association areas
• integrates many sensory inputs into a common thought
• transmits results to appropriate effectors
Frontal eye field (frontal cortex)
• controls voluntary scanning eye movements

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Telencephalon: Cerebral Higher-Order Functions***

• Higher-order functions
• performed by cerebral cortex
• involves communication bet. cerebral cortex & other areas of brain
• requires conscious & unconscious info processing
• subject to modifications & adjustments

• Integrative centers of cerebral cortex
• integrate complex sensory stimuli & motor responses
• prefrontal cortex
• general interpretive area
• Broca’s area
• Wernicke’s area

• Hemispheric lateralization: each hemisphere has different functions
• left: speech center, writing, language, mathematics
• right: analysis by touch, spatial visualization

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Integrative Regions of the Cerebral Cortex***

knowt flashcard image
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The Cranial Nerves and Functions MATCHING QUESTION 12 POINTS*************

don’t need to know the sensory/andor motor

know the red box

<p>don’t need to know the sensory/andor motor</p><p>know the red box</p>
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Cranial Nerves

• 12 pairs (I-XII) of cranial nerves
• innervate the periphery emerging from the brain (not the spinal cord)
• located on brain’s ventrolateral surface
• numbered beginning at anterior aspect of brain

put on card*

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