Lab Practical Exam 2

What two things normally go together?

toxic granulation and dohle bodies

What is the gene that causes a true pelger huet

Lamin B receptor gene

pelger huet cells that are found in myeloproliferative disorders are referred to as what?

pseudo pelger huet

Do pelger heut cells function the same as a normal neutrophil?

Yes

What do chediak higashi cells have

ginat fused lysosomes

Can bacteria be killed in chedick hagshi?

no

What disorder has an extremely HIGH +++ WBC count?

CML

What disease an extremely high +++ RBC count?

polycythemia vera

What red cell morphology abnormality is in patients with myelofibrosis

Teardrop cells

What disease state has a very HIGH +++ PLT count?

Thromobocytothemia

What is the LAP score for a patient with CML?

Decreased with a positive Philadelphia chromosome

What do patients with myelofibrosis have?

positive reticulinin, positive silver stain

What is the plt count for someone with thrombocytothemia?

over 1,000,000/uL

What is the rbc mass and o2 sat for someone with polycythemia vera

increased rbc mass with a normal o2 sat

What is the LAP stain used for

to determine the leukemoid reactions. this is due to infections

Is the LAP score decreased or increased in pregnancy?

increased

What is the normal range for LAP score?

20-170

A leukemoid reaction is what?

>100

What is the LAP score for someone with CML?

<13

What is also considered as a Leukemoid reaction?

HIGH +++ Neutrophils

ALL - L1 describe this

small, uniform lymphoblasts

What age group is ALL

children

What is the most common form of ALL?

ALL-L1

ALL-L2 what kind of cells are seen?

Large, pleomorphic lymphoblasts

What age group is ALL-L2 found in?

Often found in ages over 15

What kind of cells are seen in ALL - L3?

Burkitts cells

What protein is absent in Burkitts lymphoma that causes cells to rapidly proliferate?

B-cell Lymphoma protein

What stage of ALL has the worst prognosis?

L3 - Burkitts

What cells are seen in CLL *hint: there are 3 listed!

Usually B cells

Mature lymphocytes

Smudge cells!

What must the lymphocytosis be for CLL?

>= 5,000/uL

What cells are seen in infectious mononucleosis

atypical lymphocytes

What is the main thing we want to recognize when we see hairy cells?

They will be TRAP stain positive!

What kind of lymphocytes are seen in sezary cell leukemia

marked convolutions on the lymphocyte

What is another word for Sezary syndrome?

Mycosis fungoides

What does the bone marrow of Multiple Myeloma show

an increased number of mature plasma cells that grow in sheets or clusters

What causes Gauchers disease?

a defect in the B-glucocerebrosidase

What causes Niemann-Pick disease?

a defect in the lysosomal hydrolase enzyme sphingomyelinase

What type of histiocytes are in Gauchers?

“tissue paper” like

What type of histiocytes are seen in niemann pick

“fat droplets” histiocytes