Hormone Therapy in Breast Cancer Treatment
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Last updated 8:53 PM on 3/8/25
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20 Terms
1
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What are hormones?
Hormones are chemical messengers that regulate body functions.
2
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What are the female sex hormones produced by ovaries?
Oestrogen and progesterone.
3
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What is hormone therapy?
Hormone therapy blocks or reduces hormone levels to slow or stop tumour growth.
4
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What types of breast cancer are based on receptor status?
ER-positive (oestrogen receptor-positive), PR-positive (progesterone receptor-positive), HR-negative (no hormone receptors).
5
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What is ovarian ablation?
A method that reduces oestrogen production in premenopausal women through surgical or other means.
6
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What are aromatase inhibitors used for?
They prevent the conversion of androgens into oestrogen, mainly used in postmenopausal women.
7
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Name two examples of aromatase inhibitors.
Anastrozole (Arimidex®) and Letrozole (Femara®).
8
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What are SERMs?
Selective Oestrogen Receptor Modulators that block oestrogen receptors in breast tissue.
9
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What is the role of Tamoxifen in hormone therapy?
Blocks oestrogen receptors in breast tissue.
10
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Describe adjuvant therapy.
Hormone therapy given after surgery to reduce the risk of recurrence.
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What is neoadjuvant therapy?
Hormone therapy used to shrink tumors before surgery.
12
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Can hormone therapy prevent breast cancer in high-risk women?
Yes, it can reduce breast cancer incidence.
13
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What are common side effects of hormone therapy?
Hot flashes, night sweats, vaginal dryness.
14
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What serious side effect is associated with Tamoxifen?
Blood clots and stroke.
15
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What interactions should be aware of when using hormone therapy with SSRIs?
SSRIs inhibit CYP2D6, reducing Tamoxifen metabolism.
16
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What is the action of Goserelin?
A GnRH agonist that suppresses ovarian function.
17
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What does Fulvestrant do?
A pure antioestrogen that degrades oestrogen receptors.
18
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How do aromatase inhibitors work?
They reduce or prevent the production of oestrogen.
19
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What is the significance of hormone receptor status in breast cancer therapy?
It guides personalized treatment for hormone receptor-positive breast cancers.
20
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What key takeaway is associated with hormone therapy?
It is a cornerstone of breast cancer treatment, using various methods to block oestrogen.
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