Cardiovascular System Treatments

Class IA antiarrhythmic agents

Indications: Supraventricular and ventricular tachycardia

Class IA antiarrhythmic mechanism of action

Binds and blocks fast sodium channels that cause rapid depolarization of fast-response cardiac action potentials (phase 0)

Class IA antiarrhythmic adverse reactions

Ventricular fibrillation, QT prolongation, seizures, dizziness, and drowsiness

Class IA antiarrhythmic drug interactions

TCAs and fluoroquinolones

Class IA antiarrhythmic contraindications and cautions

Electrolyte abnormalities, renal impairment, and elderly patients

Class IA antiarrhythmic notes

Must be taken at prescribed levels. Do not skip doses unless directed by the physician.

Alcohol and nicotine should not be taken with antiarrhythmics.

Swallow whole; do not crush or chew extended-release dosage forms.

Procainamide should be taken on an empty stomach.

Quinidine should not be taken with grapefruit juice.

Generic: disopyramide

Brand names: Norpace, Norpace CR

Dosage form: capsule

Dosage: 150 mg PO q6h

Generic: procainamide

Brand: N/A

Dosage form: solution

Dosage: 1-6 mg/min IV

Generic: quinidine

Brand: N/A

Dosage forms: tablet, ER tablet

Dosage: varies by condition

Class IB antiarrhythmic agents

Indications: Supraventricular and ventricular tachycardia

Class IB antiarrhythmic mechanism of action

Inhibits the fast sodium channel while shortening the action potential duration in non-diseased tissue (Class 1 effect)

Class IB antiarrhythmic adverse reactions

Dizziness, tremors, and impaired coordination

Class IB antiarrhythmic agent

Class IB antiarrhythmic agent

Class IB antiarrhythmic agent