Classes of antibodies

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5 Terms

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IgM

  • μ

  • Membrane and blood

  • Default form made by all naive cells

  • Forms the BCR

  • Soluble form fixes complement

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IgG

  • γ

  • Blood

  • Most abundant

  • Produces after class switching from IgM

  • Neutralises toxins, fixes complement, provides long-lived protection

  • Crosses the placenta for neonatal immunity

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IgD

  • δ

  • Membrane and blood

  • A form of BCR

  • Crucial role in B cell differentiation

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IgE

  • ε

  • Serum

  • The least abundant but very important in atopic allergy and inflammation

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IgA

  • α

  • Blood and mucosal secretions such as in tears, breast milk, gut, genitourinary tract

  • provides gut immunity to neonates who don’t have their own antibodies yet