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skeletal system functions
support
protection
movement
mineral homeostasis
blood cell production
triglyceride storage
bone tissue structure
contains large amount of extracellular matrix, composed of crystalized mineral salts, collagen fibers and water. mineral salts are deposited in the collagen fiber framework (process called calcification)
classification of bones
long bones, short bones, flat bones, sesamoid bones, irregular bones
long bones
usually weight bearing long
short bones
cube shape, generate range of motion
flat bones
thin flat and protective
sesamoid bones
found in tendons and protect from wear and tear
irregular bones
bones that do not belong to any of the above categories
diaphysis
main shaft of long bone
diploe
space full of spongy bone in a long bone without any cavities
ossification/osteogenesis
bone formation
4 situations for ossification
initial bone formation
growth of bones during childhoodd and adolescence until adulthood
replacement of old worn out bone tissue
repair of fractures or bone breakage throughout the lifespan of the individual
intramenmbraneous ossification
formation of bone tissue from mesenchymal cells
endochondral ossification
formation of bone tissue from hyaline cartilage developed from mesenchymal cells
epiphyses
proximal and distal ends of the bone
articular cartilage
thin layer of hyaline cartilage covering epiphysis where bone makes articulation (joint) with another bone. lacks perichondrium.
nutrient foramina
where blood vessels enter bone
periostenum
connective tissue surrounding the bone surface not covered by articular cartilage (attatched by perforating fibers)
medullary cavity
lies in diaphysis and contains bone marrow and blood vessels
endostenum
lining medullary cavity and contains single layer of bone forming ceells and small amount of connective tissue
osteoblasts
bone building cells formed by division of osteogenic cells
osteocytes
over time osteoblasts become ___. they are mature bone cells that maintain the metabolism of the tissue
osteoclast
break down bone extracellular matrix as part of bone maintainance and repair (resorption)
compact bone tissue
composed of repeating structural units called haversian systems or osteons
osteon
contains a haversian (centeral) canal, containing a network of blood vessels, lymphatics and nerves.
concentric lamellae
circular plates of mineralized extracellular matrix surrounding central canal
lacunae
small spaces between lamellae containing osteocytes
canaliculi
connects lacune and central canal
gap junctions
what osteocytes communicate with
interstital lamellae
fragments of older osteons that have been destroyed through reobsorption during a previous bone development and growth
Volkmann’s (perforating) canals
connect periosteum with compact bone tissue and medullary cavity
inner circumferential lamellae
form the boundary between compact bone tissue and spongy bone tissue
spongy bone
doesn’t contain osteons, found in the interior of a bone protected by compact bone
spicules and trabeculae
tissue takes the form of small columns of lamellae
periosteal arteries
small arteries accompanied by nerves that enter bone through perforating canals (supply periostenum and outside compact bone)
steps of Intramembranous Ossification
Mesenchymal cells cluster together and differentiate into osteogenic cells, which produce osteoblasts.
The osteoblasts form the ossification center, and start to secrete bone extracellular matrix.
Once the osteoblasts are surrounded, they turn into osteocytes, and start the calcification process.
Trabeculae are formed to protect the blood vessels and bone marrow.
The periosteum forms around the bone.
steps of endochondral ossification
Mesenchymal cells cluster together and differentiate into chondroblasts.
The chondroblasts secrete cartilage extracellular matrix to make a cartilage model of the bone, and a perichondrium forms around the model.
The model grows in size, and the cartilage extracellular matrix starts to calcify.
Chondrocytes within the calcified area die off, leaving behind spaces that merge to become lacunae.
The development of the primary ossification center starts the process of converting cartilage into bone.
A nutrient artery penetrates the perichondrium, and stimulates the formation of osteogenic cells.
The osteogenic cells form osteoblasts.
Once osteoblasts are produced, the perichondrium becomes a periosteum for the forming bone.
The osteblasts deposit bone extracellular matrix over calcified cartilage, forming spongy bone tissue.
Osteoclasts start to break down spongy bone tissue in the middle of the bone, forming the medullary cavity.
Secondary ossification centers develop within the bone epiphyses.
Unlike primary ossification centers, no cavity develops.
Formation of articular cartilage and the epiphyseal (or growth) plate completes endochondral ossification.
The growth plate is the site of future bone growth.
bone growth lengthwise
depends on interstitial growth of cartilage in one area of bone and the conversion of cartilage into bone in another area
epiphyseal line
what froms when the epephyseal plate diseappears at the end of adolescence
bone growth in thickness
only through appositional growth occuring from outside of the bone. as osteoblasts increase the thickness of the bone, osteoclasts break down the interior of the bone (allowing the bone to grow in size while minimizing in weight)
bone remodeling
the ongoing replacement of old bone tissue with new bone tissue.
bone resorption
the removal of minerals and collagen fibers from bone tissue by osteoclasts
bone deposition
addition of minerals and collagen fibers to bone tissue by osteoblasts
steps of bone resorption
During bone resorption, osteoclasts attach to a bone tissue section, and form a leak-proof seal.
The osteoclasts then release digestive enzymes and acids into the pocket.
The digestive enzymes dissolve fibers and other organic materials.
The acids dissolve the minerals.
The digested materials are transported through the osteoclasts via transcytosis into the bloodstream.
Osteoblasts then move in to rebuild the bone in the cleared area.
bone metabolism factors
Large quantities of calcium and phosphorous are required for bone growth and remodeling. Magnesium, fluoride, and manganese are required in lesser amounts.
Insulin, insulin like growth factors (IGFs), thyroid hormones, and sex hormones also contribute to bone growth and maintenance.
Various vitamins contribute to bone formation and maintenance
vitamin A
stimulates osteoblast activity
Vitamin C
required for effective collagen synthesis
vitamin D
increases body’s ability to absorb cancium from food in the bloodstream
vitamins B12 and K
required for synthesis of bone proteins
fracture
any break in a bone
open fraccture
fracture where the broken bone end protrudes through the skin
closed fracture
broken bone ends do not break the skin
comminuted fracture
fracture where the bone is crushed into fragments at the site of the break
greenstick fracture
partial fracture where one side of the bone breaks but the other side just bends (only in children and adolescents
impacted fracture
one end of the broken bone is driven forcefully into the interior of the other end
pott fracture
fracture of the distal end of the fibula with serious damage to distal tibial atriculation
colles’ fracture
fracture of distal end of radius where the distal fragment is displased posteriorly
stress fracture
microscopic fractures that form without sign of injury to surrounding tissues
reduction
process of bringing fractured bone ends into alignment
closed reduction
involves manual manipulation
open reduction
involves surgery
fracture hematoma
disruption of blood flow by the fracture causes the formation of a mass of clotted blood
steps to bone repair
Disruption of blood flow by the fracture causes the formation of a mass of clotted blood called a fracture hematoma.
Nearby bone cells die due to a lack of blood flow.
Swelling and inflammation occur from the dead bone cells.
Phagocytes and osteoclasts start to remove the dead and damaged tissue.
The process may last for six to eight weeks.
Fibroblasts from the periosteum migrate to the fracture site and produce collagen fibers.
Chondroblasts from the periosteum produce fibrocartilage within the fracture site.
The two cell types cooperate to form a mass of repair tissue called a fibrocartilaginous (soft) callus that bridges the fracture.
The process takes about three weeks.
Osteoblasts begin to produce spongy bone trabeculae within the fracture.
The trabeculae join the living and dead portions of the original bone fragments.
The fibrocartilage is gradually converted into spongy bone tissue, converting the soft callus into a bony (hard) callus.
This process takes about three to four months.
Dead portions of the original bone are gradually resorbed by osteoclasts.
Compact bone tissue replaces spongy bone tissue around the surroundings of the fracture.
The repair process of bone remodeling may be so thorough at to be virtually undetectable under an x-ray.
However, a thickened area on the bone surface remains as evidence of a previous fracture.
calcium
stored in bone, plays key roles in nerve and muscle function as well as blood clotting and enzyme function.
Parathyroid hormone
increasing osteoclast resorption rates resulting in omre calcium entering the bloodstream
calcitonin
implicated in inhibiting osteoclast activity and accelerating calcium deposition
demineralization
result of the loss of calcium and other minerals from the bone extracellular matrix
brittleness
results from decreased protein synthesis
osteoporosis
a growing porosity of bones resulting in greatly increased incidences for fractures
rickets and osteomalacia
bone disorders resulting from insufficinet calcification of bone and extracellular matrix
osteoarthritis
The degeneration of articular cartilage so that bones are in direct contact with each other.
osteomyelitis
is an infection of bone tissue, and is usually caused by bacteria such as S. aureus
Osteopenia
disorder of low bone mass, usually caused by bone loss rates higher than bone gain rates
osteosarcoma
cancer within bone tissue primarily affected by osteoblasts
hypercalcemia
too much calcium in blood
hypocalcemia
too little calcium in blood
what leads to loss of bone mass?
decrease of hormone prodduction in old age
rickets and osteomalacia
disorder resulting from insufficient calcification of bone extracellular matrix. rickets are children osteomalacia is adults and both are usually caused by lack of vitamin D
axial skeleton
skull and vertebral column, sternum, and rib bones (responsible for protecting and supporting internal organs
appendicular skeleton
includes pectoral and pelvic girdles and bones of limb (responsible for movement)
articulations
regions that form joints with other bones
extensions and projections
protrude out of the bone
depressions
indents in the bone that don’t penetrate to the other side
passages and cavities
indentations that penetrate to the other side
frontal bone, two parietal bones, occipital bone, two temporal bones, sphenoid bone, and ethmoid bone.
bones of the cranium
condyle
knob that articulates with another bone
facet
smooth flat slightly concave or convex articular surface
head
prominent expanded end of a bone sometimes rounded
crest
narrow ridge
epicondyle
expanded region superior to a condyle
line
slightly raised elongated ridge
process
any bony prominence
protuberance
bony outgrowth or protruding part
spine
sharp slender narrow process
trochanter
2 massive processes unique to the femur
tubercle
small rounded process
tuberosity
rough elevated surface
alveolus
pit of socket (tooth socket)
fossa
shallow, broad, or elongated basin
fovea
small pit