plasma coagulation factors

which factor functions as a substrate

factor I

factor I is also known as

fibrinogen

what do cofactors do

accelerate enzymatic reactions

which factors act as cofactors

• III, V, VIII

• factor HMWK

HMWK stand for

high molecular weight kininogen

what enzymes are involved in coagulation cascades

• serine proteases

• transamidase

what do serine proteases do

cleave peptide bonds

which factors can serine proteases cleave

II, VII, IX, X, XI, XII

which factor does traqnsamidase work on

XIII only

are contact proteins vitamin K dependent

NO

are contact proteins consumed during clotting

NO

where can contact protein be found

in serum and plasma

what do contact proteins participate in

initial phase of the intrinsic system

contact proteins :

XII, XI , PK, HMWK

PK stands for

pre kallikrein

all factor names are noted by __ ___, except for ___ + ____

roman numerals, prekallikrein (PK) + high molecular weight kininogen (HMWK)

prothrombin proteins :

II, VII, IX, X

are prothrombin proteins dependent on vitK

yes

are prothrombin proteins consumed during clotting

no, except for factor II

which prothrombin protein is consumed during clotting

II

what are prothrombin proteins present in

fresh and stored plasma and serum

fibrinogen proteins

I, V, VIII, XIII

are fibrinogen proteins consumed in clotting

yes

are fibrinogen proteins found in serum? why or why not

no, because they are consumed during clotting

are fibrinogen proteins dependent on vitamin K

no

when do fibrinogen proteins increase

• acute phase

• pregnancy

• inflammation