beta oxidation and synthesis of FA melhorar

triacylglycerol

Glycerol

Dihydroxyacetone

Acyl CoA

Enoyl CoA

beta oxidation of fatty acids

Propionyl CoA

(S)-methylmalonyl-CoA

(R)-Methylmalonyl CoA

SuccinylCoA

Acetyl CoA

Acetoacetyl-CoA

Malonyl CoA

Ketoacyl CoA

hydroxybutyryl ACP

Crotonyl ACP

Butyryl ACP

liver, skeletal muscle, adipose tissue

where does the synthesis occur?

regulatory enzyme of fatty acid synthesis

acetyl-coa synthase

Carnitine

Carnitine

CAT I- carnitine acyl transferase- from cytosol of outer m

Acylcarnitine translocase- put into the matrix

CAT II- carnitine acyl transferase- enzyme is in mit matrix

CAT complex

complex fatty acid synthase

2 subunits enzyme

each subunit 3 domains

each domain has a different function

binds intermediated on thiol group of cysteine

this complex is ATP independent

Malonyl CoA

inhibits beta oxidation- lipolysis

synthesis needs

degradation needs

synth: NADPH

degradation: NAD+, FAD+

FA synthesis regulatory enzyme

acetyl-CoA synthase

ACETYL.COA synthase

activated by insulin and citrate

inhibited by palmotyl-CoA and AMP

Citrate stimulates because

makes NADPH in its shuttle from mit to cytosol where synthesis occurs

linoleic and linolenic acid

we cannot produce