beta oxidation and synthesis of FA melhorar

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triacylglycerol

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Glycerol

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29 Terms

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triacylglycerol

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Glycerol

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Dihydroxyacetone

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Acyl CoA

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Enoyl CoA

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beta oxidation of fatty acids

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Propionyl CoA

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(S)-methylmalonyl-CoA

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(R)-Methylmalonyl CoA

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SuccinylCoA

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Acetyl CoA

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Acetoacetyl-CoA

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Malonyl CoA

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Ketoacyl CoA

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hydroxybutyryl ACP

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Crotonyl ACP

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Butyryl ACP

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liver, skeletal muscle, adipose tissue

where does the synthesis occur?

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regulatory enzyme of fatty acid synthesis

acetyl-coa synthase

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Carnitine

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Carnitine

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CAT I- carnitine acyl transferase- from cytosol of outer m

Acylcarnitine translocase- put into the matrix

CAT II- carnitine acyl transferase- enzyme is in mit matrix

CAT complex

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complex fatty acid synthase

2 subunits enzyme

each subunit 3 domains

each domain has a different function

binds intermediated on thiol group of cysteine

this complex is ATP independent

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Malonyl CoA

inhibits beta oxidation- lipolysis

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synthesis needs

degradation needs

synth: NADPH

degradation: NAD+, FAD+

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FA synthesis regulatory enzyme

acetyl-CoA synthase

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ACETYL.COA synthase

activated by insulin and citrate

inhibited by palmotyl-CoA and AMP

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Citrate stimulates because

makes NADPH in its shuttle from mit to cytosol where synthesis occurs

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linoleic and linolenic acid

we cannot produce