triacylglycerol
Glycerol
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triacylglycerol
Glycerol
Dihydroxyacetone
Acyl CoA
Enoyl CoA
beta oxidation of fatty acids
Propionyl CoA
(S)-methylmalonyl-CoA
(R)-Methylmalonyl CoA
SuccinylCoA
Acetyl CoA
Acetoacetyl-CoA
Malonyl CoA
Ketoacyl CoA
hydroxybutyryl ACP
Crotonyl ACP
Butyryl ACP
liver, skeletal muscle, adipose tissue
where does the synthesis occur?
regulatory enzyme of fatty acid synthesis
acetyl-coa synthase
Carnitine
Carnitine
CAT I- carnitine acyl transferase- from cytosol of outer m
Acylcarnitine translocase- put into the matrix
CAT II- carnitine acyl transferase- enzyme is in mit matrix
CAT complex
complex fatty acid synthase
2 subunits enzyme
each subunit 3 domains
each domain has a different function
binds intermediated on thiol group of cysteine
this complex is ATP independent
Malonyl CoA
inhibits beta oxidation- lipolysis
synthesis needs
degradation needs
synth: NADPH
degradation: NAD+, FAD+
FA synthesis regulatory enzyme
acetyl-CoA synthase
ACETYL.COA synthase
activated by insulin and citrate
inhibited by palmotyl-CoA and AMP
Citrate stimulates because
makes NADPH in its shuttle from mit to cytosol where synthesis occurs
linoleic and linolenic acid
we cannot produce