CHEM022 Enzyme Prosthetic Groups

Thiamine (B1)

Riboflavin

Niacin

Pyridoxine (B6)

Pantothenic Acid

Biotin

6 Vitamins with CO-Enzymes

Thiamine pyrophosphate (TPP)

co-enzyme of Thiamine

Flavin adenine nucleotide (FAD)

Flavin adenine mononucleotide (FMN)

2 co-enzymes of riboflavin

Nicotinamide adenine dinucleotide (NAD+)

co-enzyme of Niacin

-Pyridoxal phosphate (PLP)

co-eznyme of Pyridoxine

Coenzyme A (CoASH)

co-enzyme of Pantothenic acid

Biocytin

co-enzyme of Biotin

Beri-Beri

Wernicke-Korsakoff Syndrom

2 deficiency disorders of Thiamine (B1)

Scaly dermatitis

Angular cheilitis

Glossitis

3 deficiency disorders of Riboflavin

Pellagra

Glossitis

2 deficiency disorders of Niacin

Neurologic disruptions

Anemia

Glossitis

3 deficiency disorders of Pyridoxine

Not established since it is very widespread in food

deficiency disorder of Pantothenic acid

Dermatitis

Hair loss

Muscle Pain

3 deficiency disorders of Biotin

loss of appetite, peripheral neuropathy, fatigue, loss of muscle coordination (ataxia)

Beri-Beri

milder form of Beri-Beri

Wernicke-Korsakoff Syndrome

inflmmation & scaly aappearance of the skin

scaly dermatitiss

inflammation and cracking of the lip corner

angular cheilitis

redness and swelling of the tongue

glossitis

characterized by dermatitis, diarrhea, and memory loss (dementia)

pellagra

convulsions, peripheral neuropathy, irritability, depression

neurologic disruptions

Mn2+

Fe2+

Ni2+

Zn2+

4 Cofactors

Catalase

enzyme of Mn2+

Cytochromes P450

enzyme of Fe2+

Urease

enzyme of Ni2+

Alcohol dehydrogenase

enzyme of Zn2+

Catalase

function: reduction of H2O2 into H2O and O2

Cytochrome P450

function: metabolism of drugs and other foreign compounds in the body

Urease

function: hydrolysis of urea into NH3 and CO2

Alcohol dehydrogenase

function: Oxidation of alcohol into aldehyde