Tissue Damage

Leukocytosis

calls neutrophils & monocytes

injured cells release this

chemokines

leukocytosis inducing factors

fever

pyrogen - released by neutrophils and macrophages

act on hypothalamus

complement system

when early leukocytes can’t finish job

innate and adaptive

plasma proteins (require activation)

lyse foreign pathogens (kill)

complement system activation

1. classical pathway - Abs from adaptive binding

2. alternative pathway - spontaneous binding to pathogen

3. lectin pathway - lectin presence on pathogen

complement system leads to

opsonization, inflammation, membrane attack complex

Membrane attack complex

hole produced by complements

helps phagocyte

lectins

help with adhesion and infection

activate complement proteins