PHYSICAL PHARMACY

D

The buffer equation is also known as

a. noyes-whitney

b. van't hoff

c. arrhenius

d. henderson-hasselbalch

A

The dissolution of a drug is calculated suing

a. noyes-whitney

b. van't hoff

c. arrhenius

d. henderson-hasselbalch

A

The pressure of a solution is _____ by the presence of solute

a. lowered

b. raised

c. unaltered

d. developed

A

To increase the miscibility if partially miscible liquids, add the substance

a. miscible with both liquids

b. miscible with one of the liquids

c. immiscible with both liquids

d. immiscible with one of the liquids

B

The number of moles of solute per liter of solution

a. normality

b. molarity

c. molality

d. NOTA

A

The number of gram equivalents of solute per liter of solution

a. normality

b. molarity

c. molality

d. NOTA

C

The number of moles of solute per 1000g of solvent

a. normality

b. molarity

c. molality

d. NOTA

B

Crystalline form of NaCl

a. tetragonal

b. cubic

c. hexagonal

d. monoclinic

A

A type of solution where the dispersed phase is uniform throughout the solution

a. true solution

b. suspension

c. coarse dispersion

d. colloidal dispersion

B

Diffusion mechanism whereby drugs are transported form the region of high to low concentration

a. active

b. passive

c. facilitated

d. AOTA

A

Diffusion mechanism whereby drugs are transported form the region of low to high concentration

a. active

b. passive

c. facilitated

d. AOTA

C

An equation which reveals the rate of diffusion of a drug

a. noyes-whitney

b. nernst film theory

c. fick's first law

d. fick's second law

D

The following statements are true for dustibility, except

a. it signifies the opposite if stickiness

b. it characterizes the free flowing powders

c. it has some relation to the uniform spreading of dusting powders when applied to skin

d. it is a measure of the cohesiveness of particles of a compacted powder

A

Complete wetting of a surface occurs when the contact angle between a liquid droplet and the surface is

a. 0

b. 160

c. 180

d. 90

D

Gels and magmas when standing form semisolid and on shaking become fluid are said to be

a. plastic

b. newtonian

c. dilatant

d. thixotropic

A

The attractive forces between polar molecules, that is, between molecules that posses dipole movement

a. keesom

b. dispersion

c. van der waals

d. ion-dipole

C

The existence of elemental substance such as carbon and sulfur in more than one crystalline form

a. polymerism

b. isomerism

c. polymorphism

d. polymorphs

B

A method of measuring tonicity which is based on the effect of various solutions of the drug observed on the appearance of red blood cells suspending in the solutions

a. cryoscopic method

b. hemolytic method

c. freezing point drepression

d. NaCl method

D

The effect of pressure on the solubility if a gas is expressed by ____________, which states that in every diluted solution at constant temparature, the concentration of dissolved gas is proportional to the partial pressure of the gas above the solution at equilibrium

a. stoke's law

b. raoult's law

c. newton's law

d. henry's law

B

The attractive interaction between a polar molecule and the induces dipole

a. ion-induced dipole

b. dipole-induced dipole

c. induced dipole

d. ion-dipole

B

The following are not cationic surfactants, except

a. potassium laurate

b. quaternary NH4 compounds

c. Na lauryl sulfate

d. triethanolamine stearate

B

The bulk density of a powder depends primarily on the fallowing, except

a. particle size distribution

b. particle sedimentation

c. particle shape

d. tendency of the particles to adhere to one another

B

When the stress removed, a _________ system returns to its original state of fluidity

a. plastic

b. dilatant

c. pseudoplastic

d. newtonian

A

An example of liquid-liquid interface

a. emulsion

b. suspension

c. mixture

d. gels

D

The degree of adsorption of a gas by a solid depends on the

a. chemical nature of the adsorbent

b. surface area of the adsorbent

c. temparature

d. AOTA

C

The following are methods of determining particle size, except

a. sedimentation

b. optical microscopy

c. density

d. particle volume measurement

A

The ratio of the void volume to the bulk volume of the packing

a. porosity

b. packing arrangement

c. bulkiness

d. flow property

C

Type of particle density which is determined by the displacement of mercury

a. true density

b. bulk density

c. granule density

d. void volume

B

Kinematic viscosity is also know as

a. relative viscosity

b. absolute viscosity

c. fluidity

d. stress

D

Viscosity of a pseudoplastic substance decrease with increasing

a. shear stress

b. temparatureD

c. pressure

d. rate of shear

A

As the temparature increase, the solubility of most gases decreases owing to the greater of the gas to

a. expand

b. diffuse

c. bind

d. scatter

B

The following are not organic molecular complexes

a. clathrates

b. picric acid type

c. channel lattice type

d. olefin type

C

The following are method of determining the type of emulsions, except

a. dye method

b. conductivity test method

c. cryoscopic test

d. dilution test

D

The change of emulsion type from o/w to w/o or vice versa is known as

a. coalescence

b. breaking

c. creaming

d. phase inversion

C

Relatively insoluble

a. less than 1 part soluble

b. 100-1000 parts

c. more than 10000 parts

d. less than 10000 parts

A

The following are hydrophilic substitute, except

a. alkyl group

b. amino group

c. hydroxyl group

d. carbonyl group

B

Molecular weight and mass are example of ___________ property

a. colligative

b. additive

c. constitutive

d. NOTA

A

Water is a __________________ liquid

a. newtonian

b. plastic

c. pseudoplastic

d. dilatant

B

Proposed law of heat summation

a. boyle's law

b. hess law

c. charles' law

d. gay lussac's law

B

As the length of a non-polar chain of an aliphatic alcohol increases the solubility if the compound in water

a. increases

b. decreases

c. no effect

d. all

A

Type of reaction wherein the rate is independent of the concentration of reactant

a. zero order reaction

b. first order reaction

c. second order reaction

d. third order reaction

A

The fastest order of reaction to decompose, since according to its differential rate expression, it is independent of the remaining concentration of the drug after decomposition

a. zero

b. psuedo-first

c. first

d. second

B

This type of solution has a solute concentration equivalent to its limit of solubility. This would mean that if the same solute is added to this solution, even in minute amounts, will lead to crystallization precipitation or insolubility of that solute

a. unsaturated solution

b. saturated solution

c. supersaturated solution

d. NOTA

C

Example of constitutive property

a. mass

b. molecular weight

c. optical activity

d. temparature

D

The increase of mutual solubility of 2 partially miscible solvent by another agent is referred to as

a. solvation

b. salting out

c. micellar solubilization

d. blending

C

Number of moles per kilogram solvent

a. molarity

b. normality

c. molality

d. percentage expression

C

One of these exhibit dilatant flow

a. cream

b. ointment

c. paint

d. acacia mucilage

B

Which the following statements is true?

a. solubility increases with increased particle size

b. solubility increases with decreased particle size

c. solubility decreases with increased particle size

d. solubility decreases with decreased particle size

D

Ascorbic acid is the least stable of all vitamins. Its instability os via this reaction

a. photolysis

b. hydrolysis

c. NOTA

d. oxidation

D

This method of determining the overall order of reaction involves the used of different plots. The plot form a straight line that will determine the order

a. half-life method

b. substitution method

c. integrated rate method

d. graphical method

C

If 1 gram of solute dissolves in 30-100 parts of solvent, the solute is said to be

a. freely soluble

b. soluble

c. sparingly soluble

d. very slightly soluble

C

Method of adjusting the tonicity of a solution to conform that of the blood and lacrimal fluid based on the adjustment of the freezing point of the solution to -0.52c

a. NaCl equivalent method

b. white vincent method

c. cryoscopic method

d. sprowls method

C

Method of adjusting the tonicity if a solution to conform that of the blood and lacrimal fluid based on the adjustment of the freezing point of the solution to 0.9% NaCl

a. NaCl equivalent method

b. white vincent method

c. cryoscopic method

d. sprowls method

D

Method of adjusting the tonicity of a solution to conform that the blood and lacrimal fluid based on the use of calculated volume V values when the weight of the drug is 0.3 g followed by the dilution of this solution with an already isotonic usually buffered solution to appropriate

a. NaCl equivalent method

b. white vincent method

c. cryoscopic method

d. sprowls method

C

Equation showing the buffer capacity of a solution

a. raoult's law

b. stoke's law

c. van slyke

d. van hoff

A

Using white-vincent method, compute for the required volume to make o.3g of atropine sulfate (E=0.13) isotonic.

a. 4.3ml

b. 3.9ml

c. 25.6ml

d. 33.3ml

C

Maximum buffer capacity can be observed in buffer solution with

a. pH lesser than pKa

b. pH greater than pKa

c. pH equals pKa

d. pKa greater than pH

A

Complexation which involves entrapment of one compound in the molecular framework of another

a. inclusion

b. chelation

c. true bond complexation

d. charge bond complexation

B

Group which donate electron pair to a central atom to form the coordinate complex

a. metal substrate

b. ligand

c. chromosphere

d. tautomer

C

Maximum number of atoms or group that can combine in the coordination sphere with a central atom

a. ionization number

b. central atom number

c. coordination number

d. valence number

D

The expression of property or reaction of a metal without removal of the metal form from the system

a. coordination

b. stabilization

c. senstization

d. sequestration

C

The type of complexation involve in warfarin sodium USP

a. chelation

b. channel lattice type

c. clathrate

d. monomolecular

B

The type of complexation involve in starch iodine complex

a. chelation

b. channel lattice type

c. clathrate

d. monomolecular

A

The type of complexation involve in calcium EDTA complex

a. chelation

b. channel lattice type

c. clathrate

d. monomolecular

A

0.75% sodium chloride aqueous solution is

a. hypotonic

b. isotonic

c. hypertonic

d. isoosmotic

B

When the rate of the reaction is proportional to the first power of the concentration of one reactant, the reaction order is

a. zero order

b. first order

c. second order

d. third order

B

The force of attraction between molecules of different phases

a. electrostatic force

b. adhesion force

c. cohesion force

d. van der waal's force

C

The force of attraction between molecules of same phases

a. electrostatic force

b. adhesion force

c. cohesion force

d. van der waal's force

A

Range of HLB value in the Griffin Scale for anti-foaming

a. 1-3

b. 3-8

c. 8-16

d. 16-18

D

Range of HLB value in the Griffin Scale for solubilizing agents

a. 1-3

b. 3-8

c. 8-16

d. 16-18

B

Range of HLB value in the Griffin Scale for w/o emulsion

a. 1-3

b. 3-8

c. 8-16

d. 16-18

B

A colloidal system in which the colloidal particles shows little attraction for the dispersion medium

a. lyophilic

b. lyophobic

c. hydrophobic

d. association

C

The breaking up of aggregates brought about by the addition of deflocculating agent

a. condensation

b. lyophilic dispersion

c. peptization

d. association

C

Which of the following is an example of an association colloid?

a. carboxumethylcellulose

b. bentonite

c. anionic surfactant

d. acacia

B

Colloidal dispersion which is unstable, irreversible and forms nonspontaneously

a. lyophilic dispersion

b. lyophobic dispersion

c. association colloid

d. lipophilic dispersion

A

The concentration of surfactant's monomer to bring about micelle formation

a. critical micellar concentration

b. aggregation number

c. critical monomer concentration

d. monomer number

C

The ability of surfactants to enhance the solubility if insoluble compounds in the dispersion medium

a. micellization

b. flocculation

c. solubilization

d. stabilization

B

The protective effect of a colloid is expressed in terms of

a. schulze-hardy rule

b. gold number

c. lyotropic series

d. sedimentation volume

A

The upward movement of dispersed droplets relative to the continuous phase

a. creaming

b. sedimentation

c. aggregation

d. coalescence

A

The natural shrinking of gel caused by coarsening of the matrix

a. syneresis

b. bleeding

c. swelling

d. imbibition

D

The taking up of liquid by a gel without the significant change in its volume

a. syneresis

b. bleeding

c. swelling

d. imbibition

B

The liberation of oil or water from ointment base resulting from a deficient gel structure

a. syneresis

b. bleeding

c. swelling

d. imbibition

C

The significant increase in the volume of a gel caused by the addition of interpenetrating liquid

a. syneresis

b. bleeding

c. swelling

d. imbibition

B

The expression of the resistance of of fluid flow

a. fluidity

b. viscosity

c. stiffness

d. elasticity

B

Unit used to express absolute viscosity

a. no unit

b. poise

c. stokes

d. dynes/cm

A

Unit used to express relative viscosity

a. no unit

b. poise

c. stokes

d. dynes/cm

C

Unit used to express kinematic viscosity

a. no unit

b. poise

c. stokes

d. dynes/cm

A

Which of the following flow system shows a yield value?

a. plastic

b. pseudoplastic

c. newtonian

d. dilatant

A

In which of the following system does the rheogram plot does not pass thorough the origin?

a. plastic

b. pseudoplastic

c. newtonian

d. dilatant

D

Which of the following is referred to as shear thickening?

a. plastic

b. pseudoplastic

c. newtonian

d. dilatant

B

Which of the following is referred to as shear thinning?

a. plastic

b. pseudoplastic

c. newtonian

d. dilatant

C

The comparatively slow recovery of the consistency of a material lost through shearing defines

a. rheopexy

b. dilantancy

c. thixotropy

d. negative thixotropy

A

Cup and bob viscometer type where the bob is rotated

a. searle type

b. coutte type

c. cone and plate type

d. oswald type

C

Flow of liquid out of the capillary obeys

a. stoke's law

b. hooke's law

c. poiseulle's law

d. graham's law

C

Which of the following forms of radiation is the most penetrating?

a. alpha

b. beta

c. gamma

d. electron

A

Atoms of different elements having the same number of neutrons

a. isotones

b. isobars

c. isomers

d. isotopes

Equation that gives the relationship between the vapor pressure and the absolute temparature of a liquids

a. raoult's law

b. clausius-clapeyron equation

c. van slyke equation

d. vant hoff equation

D

Surfactants are

a. lipophiles

b. hydrophiles

c. hyophiles

d. amphiphiles

D

The concentration of a gas, liquid, or solid on the surface of a liquid or solid is

a. solubility

b. diffusion

c. absorption

d. adsorption

C

An isotonic solution has the same

a. pH as the blood

b. fluid pressure as the blood

c. salt content as the blood