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why measure perception
offers clues about nature of the brain, how it processes information, and the biological reasons that lead to sensation and perception.
perception
subjective, private experience of stimuli
physical stimuli
quantifiable, real, can be measured
threshold
minimum amount of detectable stimuli
scaling
measuring private experience
signal detection theory
measuring difficult decision ex. did you see a light or was it your imagination
sensory neuroscience
how do sensory nerves and receptors underlie our perceptual experiences
neuroimaging
what parts of the brain are active during different tasks
computational methods
can we create models of sensory systems that adapt and learn like humans do
charles Darwin contributions
theory of evolution, suggested continuity in structure and function of senses and nervous systems
johannes muller contributions
doctrines of specific nerve energies, we are only aware of the activity in our nerves, and cannot be directly aware of the world itself, it is most important which nerve is stimulated not how
Hermann van helmholtz contributions
first to effectively measure how fast neutrons transmit their signals, neutrons obey laws of physics
Santiago Ramon y Cajal contributions
made drawing soft neurone and their connections, suggested that neutrons are discrete entities that don't actually ouch each other, neuron doctrine
sir charles sherrington contributions
coined the term synapse (to clasp)
otto loewi contributions
discovered the first ever neurotransmitter (acetylcholine), two prove that neutrons use chemical not electrical signals
sir alan hodgkin and sir andrew huxley contributions
used squid models to discover the ionic basis of the resting potential and action potential
afferent
signals travelling towards the CNS
efferent
signals travelling away from the CNS
transduction
starts the process of all sensation, conversion of external energy into an electrical signal (receptor potential), always mediated by opening/closing ion channels which changes the membrane potential
ligand
ion or molecule that bonds reversibly
ligand gated channel
cell is receiving and transducing, opens a channel pore that allows specific ions to pass through membrane
g protein coupled receptor
ligand binds g protein coupled receptor, GPCR activates a g protein, g protein initiates a signal that ultimately opens ion channels
stretch/pressure gated channels
deformation of the membrane causes the protein to change configuration, opens a channel pore that allows specific ions to pass
receptor potential
change in membrane potential of sensory receptor, depolarize cells to reach action potential threshold ex. touch
law of dynamic polarization
unidirectional flow of information within the neuron
synaptic transmission
how sensory signals are relayed to other neuron's
neurotransmitter
chemical messenger packed into vesicles, bind to specific receptors on postsynaptic cells
steps to chemical synaptic transmission
1. synaptic vesicles containing neurotransmitters travel down axon terminal
2. voltage gated Ca2+ channel opens to depolarize cell
3. neurotransmitters are released into the synapse and enzyme and receptors bind to them and absorb into the postsynaptic neuron
4. reuptake molecules recycle neurotransmitters
5. leftover neurotransmitters are diffused out of synaptic cleft
synaptic potential
caused by binding of neurotransmitters to post synaptic receptors
depolarization
excitatory response to membrane potential being above threshold causing action potential to fire
hyper polarization
inhibitory response to the membrane potential being brought down below threshold to inhibit firing of an action potential
bipolar neurons
one axon and one dendrite, generally sensory neurons
pseudo unipolar neurons
peripheral axon to send/receive signals to body, central axon to send signals to CNS, sensory neurons
multipolar neurons
many dendrites emerging from cell body, many places where signals are sent/received, generally motor and interneurons
stimulus location
topographical relationships maintained from sensory organ to primary cortical site
receptive field
each neuron in cortical areas are stimulated only if corresponding sensory area is stimulated
intensity
absolute threshold is largely determined by minimum receptor potential, more intense stimulus=larger receptor potential=greater action potential frequency
adaptation
frequent exposure to a stimulus leads to reduced awareness, adaptation of sensory receptors
modality
sensory receptors are sensitive to a specific type of energy
axes of CNS
long axis has a bend in it, must consider when applying anatomical terms
4 lobes of brain
temporal, frontal, occipital, parietal
gyri
crests of filed cortical issue
sulci
grooves that divide gyri
visual cortex
vison
auditory cortex
hearing
motor cortex
motor movements in body
somatosensory cortex
skin sensations
olfactory cortex
smell
primary receiving area
where all sensory input first arrive in the cerebral cortex
poly sensory
where information from more than one sense is combined
association areas
where sensory information travels after leaving the primary receiving area
cerebral cortex
thin layer of neural tissue that covers the entire cerebrum, made of 6 layers called the neocortex
white matter
axon tracts and commissures
nuclei
local groups of neurons that have roughly similar connections and functions
thalamus
major relay station, all sensory signals except smell travel through thalamus on their way to the cortex
spinal cord
transmits sensory and motor information to and from the brain
brainstem
composed of the pons, medulla and midbrain, relays motor information from the brain
ganglion
local accumulations of neutrons and glia in the PNS
peripheral nerves (31 pairs)
bundles of peripheral axons ensheathed by glial cells
intracellular recording
measures voltage changes across the cell membrane, compares the voltage inside vs outside the cell, can detect small changes in membrane potential
extracellular recordings
measure voltage changes just outside of the cell, compares activity from outside cell membrane to an inactive area, can only detect big changes in MP such as action potentials
pros and cons of electrophysiological recording
can only record one neuron at once, can't be used in humans, good spatial and temporal resolution
neuroimaging
A set of methods that generate images of the structure and/or function of the brain.
EEG
measures electrical activity through dozens of electrodes placed on the scalp, get baseline brain activity, then present stimulus, average responses to stimuli
pros and cons of EEG
can see what parts of brain are active during stimulus presentation, can tell if neural signalling is slow, noninvasive, low spatial resolution, high temporal resolution
MEG
measures changes in tiny magnetic fields across populations of many neurons in the brain. uses a SQUID to localize populations of active neurons
pros and cons of MEG
costly and hard to perform, better at localizing subcortical structures
MRI
patient is placed in a large powerful magnet that influences the way the hydrogen in the brain spins, then radio frequency is pulsed, causes the atoms to spin out of equilibrium, sensors detect energy released after pulse and produces a 3d image of brain
pros and cons of MRI
detailed structural images, no functional information, no radiation, detailed pictures of soft tissues where lots of hydrogen is present
fMRI
magnetic pulses pick up oxygen rich areas in brain, more active neurons need more oxygen rich blood, measures oxygenated blood in the brain then baseline, subtracts baseline from amount of oxygenated blood in areas when stimulus present.
pros and cons of fMRI
delayed responses, indirect measure of activity, shows activity in subcortical structures, non invasive
PET
radioactive tracer injected into bloodstream, camera detects radiation emitted from brain regions which are more metabolically active therefore using more tracer.
pros and cons of PET
low spatial resolution, invasive, subcortical structures visible
mathematical models
use mathematical language, concepts, and equations to closely mimic psychology and neuronal processes
computation models
use mathematical language, and equations to describe steps in psychological or neural processes, can predict processes based off patterns
efficient coding models
assume that sensory systems are predictable in natural environments, economically encode predictable sensory inputs while highlighting less predictable input
bayesian models
assume earlier observations should bias expectations for future events to build a model of the world, predictive coding
linear change in stimulus intensity and perceived sensation
as intensity changes, sensation increases by an equal unit
exponential change in stimulus intensity and perceived sensation
at a high level, a small stimulus intensity change causes a large change in perception
logarithmic change in stimulus intensity and perceived sensation
at a low level, a small stimulus intensity change causes a large change in perception
absolute threshold
minimum stimulus level required to be registered by brain as a sensory event, has to be enough stimulation to activate neuron
sub threshold
below the level of detection
supra threshold
above the level of detection
3 ways to measure thresholds
1. method of adjustment
2. method of limits
3. method of constant stimuli
step function vs psychometric function
step function: always senses supra threshold stimuli, not typic psychophysics results
psychometric function: uncertainty around stimulus intensifies near absolute threshold, s shaped function
why is variability around 50% for psychometric functions?
cognitive functions vary on stimulus baseline and neuronal activity sensitivity
what determines the shape of the psychometric function?
absolute threshold, what the slope is at supra threshold levels, how the slope changes with increasing intensity
just noticeable difference
how much does a stimulus need to change in order to produce a detectable change in perception
how to find the difference threshold
present subject with 2 stimuli ask which is heavier, repeat 50 times. Calculate % of times subject said target was heavier than the reference.
perceptual equivalence point
difference detected on 50% of trials of difference threshold
webers law
delta is a constant proportion of the stimulus intensity. k (webers fraction) must be experimentally determined
what does a k value of 0.07 mean?
change 7% of stimulus to detect a difference, k% of stimulus needs to be added to notice a difference.
what sensory dimension has the lowest k value
pitch
Fechner's Law
assumes that all JND's are perceptually equivalent. for every JND amount added is different, but change in sensation is the same.
scaling
psychophysical procedure to estimate the amount of something related to perception
magnitude estimation
a scaling approach where subjects provide direct ratings of their sensations
power law
sensory experience = scaling constant x initial intensity
value of the power exponent
each sensory experience is related to stimulus intensity by an exponent. The relationship is increasing or decreasing depending on the exponent. pain is exponential
sensory transducer thoery
idea that transduction of the physical stimuli into a biological stimuli is the basis of the power law
cross modality matching
compare stimuli from one sensory modality to stimuli of another sensory modality