Miscellaneous Blood Groups

Named after the first antibody maker in a Venezuelan family

Diego (010)

Diego (010) is carried on

Band 3 or also known as

Red Cell anion exchanger (AE1) or

solute carrier family-4. Anion exchanger, member 1 (SLC4A1)

is rare in most populations but is polymorphic in people of Mongolian ancestry

𝐷𝑖𝑎

𝐷𝑖𝑎 In South American Indians, the prevalence can be as high as

54%.

is commonly found with other antibodies in Diego BGs

Anti-𝑊𝑟𝑎

Diego (010) Antigens:

22 antigens: Dia , Dib , Wra , Wrb and Wu/DISK and 17 low-prevalence antigens

Cartwright (Yt) Ags are antithetical and represent anamino acid substitution on the

glycosylphosphatidylinositol (GPI)-linked RBC glycoprotein acetylcholinesterase (AChE)

Cartwright (Yt) Ags Variably sensitive to enzymes __________

Sensitive to ___

(Ficin and Papain);

DTT

The antigens are developed at birth but are expressed more weakly on cord RBCs than on adult RBCs, and are absent from RBCs of people

with _____

Cartwright (Yt) Ags

PNH III.

Discovered in the serum of a multiply transfused man.

Xg (012)

Named in 1956 for the first antibody maker and used the last letter “t” in the patient’s last name,

Cartwright (011)

Xg (012) is Inherited on

X chromosome;

Xg (012) Ags is resistant and sensiitve to what

Sensitive to Ficin and Papain; Resistant to DTT

treatment.

● Named after the first antibody maker

● The antigens are expressed on cord RBCs

Scianna (013)

The SC gene is located on

chromosome 1 at 1p34

The product of the SC gene is a protein called

____________________________ which is an RBC adhesion protein

erythroid membrane- associated protein (ERMAP)

Scianna (013) is resistant and slightly weakened by

Resistant to Ficin and Papain; slightly weakened

by DTT.

Scianna (013)

7 antigens: SC:1, SC:2, SC:3, Sc4,

Sc5 (STAR), Sc6 (SCER), Sc7 (SCAN)

● Named for the first antibody maker, MRs. Dombrock.

● Antigens are present on cord RBCs, but are absent from PNH III RCSs.

Dombrock (014)

Dombrock (014) antigens are carried on ______________ attached to the RBC

membrane by the

mono-ADPriboslytransferase 4 (ART4)

GPI anchor

phenotype is found only in blacks

Hy

antibodies that are rarely found as a single specificity.

anto-Doa

and anti-Dob

Dombrock (014) Ags are Resistant and sensitive to

● Resistant to Ficin, Papain, and Glycine ACid EDTA.

● Sensitive to 0.2 M DTT treatment

● Named for the first antibody maker Calton but the tube was misread.

● Expressed on RBCs of newborns.

Colton (015)

Colton (015) Ag are carried on an integral membrane protein called

aquaporin 1 (AQP1)

account for 80% of water readsorption in the kidneys

aquaporin 1 (AQP1)

is rarely found as a single specificity.

Anti-Cob

The structure that carries the LW antigens is a glycoprotein known as

intracellular adhesion molecule 4 (ICAM-4),

The LW antigens may be depressed during pregnancy and in some diseases, such as

lymphoma and leukemia.

The LW antigens is resistant to

Resistant to treatment with enzymes and Glycine Acid EDTA.

The LW antigens

3 LW Antigens: LWa ,

LWab – high prevalence

LWb - low prevalence

Named after the 2 antibody producers

Chido/Rodgers (017)

Ch and Rg antigens are not intrinsic to the RBC membrane, they are on the fourth component of _______________, and are adsorbed onto RBCs from plasma

complement C4

C4B carries the

Ch antigens

C4A expresses

Rg antigens.

Ch and Rg antigens are sensitive to _____ and found in _____

enzymes

plasma

Ch and Rg antibodies have what characteristics

HTLA

Ch and Rg antigens are destroyed and are resistant to what

Destroyed by Ficin and Papain;

Resistant to treatment with DTT and Glycine Acid EDTA.