MEDORG - SEMIFINALS - CARDIOVASCULAR AGENTS

Ace-inhibitor

• are a class of drugs used in the treatment of hypertension, heart disease and chronic kidney failure

Captopril

• was discovered in 1977

• was the first ACE inhibitor developed and was considered a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process.

Enalapril

• By inhibiting the ACE, enalaprilat, the active metabolite of _____, decreases levels of angiostenin II leading to less vasoconstriction and decreased blood pressure

Fosinopril

• In animals and humans, _____ sodium is hydrolyzed by esterases to the pharmacologically active form, _____ a specific competitive inhibitor angiotensin-converting enzyme (ACE)

Angiotensin II Receptor blockers

• are medications that block the action of angiotensin I from binding to angiotensin II receptors on the muscles surrounding blood vessels.

• as a result, blood vessels enlarge (dilate) and blood pressure is reduced

Angiotensin II receptor Blocker

• may be used instead of an angiotensin-converting enzyme (ACE) inhibitor if you are not able to tolerate certain side effects of an ACE inhibitor

Valsartan

• is a new anti-hypertensive agent with the same mechanism as losartan

Calcium channel blocker

• also known as calcium antagonists

• prevent calcium from infiltrating the cells of the heart and blood vessel walls

Calcium channel blocker

• may also slow the heart rate, relieve chest pressure and control irregular heartbeat

Phenylakylamines

• used to treat angina by reducing myocardial and oxygen demand and reverse coronary vasospasm

1,4-Dihydropyridines

• the most common smooth muscle selective class, reduce systemic vascular resistance and arterial pressure

Benzothiazepines

• have both cardio-depressant and vasodilatory effect

Lotensin

• Benazepril

Capoten

• Captopril

Vasotec

• Enalapril

Monopril

• Fosinopril