Adrenergic

seminar 6

What does metyrosine inhibit

tyrosine hydroxylase

what inhibits VMAT

reserpine

what drugs inhibit NE release

bretylium and guanetidine

what can inhibit NET

cociaine and antidepressants

if a person takes MAO and COMT inhibitors what does it block

metabolism of NE

what are the two types of receptors

alpha and beta

what is the difference between alpha 1 and alpha 2

alpha 1 is Gq and alpha 2 is Gi

all 3 types of beta receptors are what cellular response

Gs

what does alpha 1 do

\-contracts eye muscles

\-contracts sphincters

\-contracts prostate

\-

what does alpha 2 do

\-decereases aqueous humor in eye

\-contracts splanchic vessels

\-uterus contraction and relaxation

\-DECREASES NE RELEASE

\-DECREASES INSULIN

what do beta 1 receptors do

\-accelerates everything in the heart

\-increases renin

what does beta 2 do

\-decrease histamine release

\-increases insulin

\-relaxes bladder

**-relaxes bronchial muscle**

\-**relaxes skeletal muscle**

what does beta 3 do

lipolysis

what are the two types of alpha agonists

direct and indirect

what is are the 3 subgroups of direct acting alpha agonists

non slective

alpha 1 selective

alpha 2 selective wh

what is non selective direct alpha agonist ?

epinephrine w

what is a alpha 1 selective direct alpha agonist

norepinerphine

midodrine

what is a alpha 2 selective direct alpha agonist

clonidine

methyldopa

what is an alpha 2 selective agonsit that is used to treat glaucoma

brimonidine

what are some indirect alpha agonist drugs

amphetamine

ephedrine

pseudoephedrine

what is the two types of alpha antagonists

non selective and alpha 1 selective

what is a non selective antagonist

nicergoline

what is an alpha 1 selective antagonist

prazosin

doxazosin

tamsulosin

what are 3 subgroups of beta agonists

non selective

beta 1 selective

beta 2 selective

what are the non selective beta agonists

epinephrine

isoprenaline

dopamine

what are the beta 1 selective beta agonists

dobutamine

what are the beta 2 short acting agonist

salbutamol

hexoprenaline

clenbuterol

what are the long acting beta 2 selective agonists

formoterol

salmeterol

what are the 4 types of beta antagonists

non selective

beta 1 selective

vasodilating

beta blockers for glaucoma

what are the non selective beta antagonsits

propanolol

sotalol

what is the beta 1 selective antagonists

metoprolol

bisprolol

atenolol

betaxolol

what are vasodilating beta antagonsists

carvedilol

nebivolol

what are the beta blockers used to treat glaucoma

timolol

betaxolol

what drug administration route is EP inactive

orally

what does NE increase

peripheral vascular resistance

how is midodrine administered

orally

what is midodrine used for

hypotension

what is a vasoconstrictor used for the nasal cavity

xylomethazoline

what drug is used to treat hypertension in pregnant women

methyldopa wha

what is clonidine used for

mirgranes

does amphetamine penerate the BBB

yes

what is the mechanism for amphetamine

releases NE at high doses

ephedrine has both indirect and direct mechanism of action

indirect: release of NE

acts on beta adregernic receptors

what is epherdrine used for

as a brochial dilator eg rhinitis

what drug is used for brain atherosclerosis

nicergoline

what drug is used to treat benign prostate hyperplasia

doxazosin, tamsulosin

what beta agonist is used for AV blockage

isoprenaline

what beta agonist is a synthetic catecholamine

dobutamine

what is dobutamine used for

heart failure

what does dobutamine stimulate

cardiac beta 1

both the long and short acting beta agonists are used for what

bronchodilation

what drug has the lowest oral bioavlaibitily

propanolol

where is atentolol elimated

kidney

how does carvedilol cause vasodilation

blocks alpha receptors h

how does nebivolol cause vasodilation

NO release

what are the effect of beta agonist blockers

decreases heart rate and contractility

decreases renin release

\-peripheral vasoconstriction ( bronchoconstriction)