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olfaction
sense of smell; olfactory nerves detect chemical odorants known as ligands
1st step of olfaction
olfactory cells have olfactory receptors (proteins) that take in odors
2nd step of olfaction
olfactory nerves are activated and send generate sensory signals
3rd step of olfaction
signals are sent to the olfactory bulb
anosmia
loss of smell; common after whiplash since delicate olfactory nerves entering vertically through the cribform plate are severed
True/False: an odor activates a specific combination of receptors
true
True/False: an odor can activate multiple receptors at once
true
True/False: different odorants can activate the same receptors
true
True'/False: some odorants can activate a combination of one receptor
true
True/False: a specific combination of odorants activates a particular receptor
false
chemotopic map
tonographic organization for olfactory sense; structurally similar odorants stimulate overlapping but distinct domains in the olfactory bulb
smelling odor step 1
odor molecules activate combination of receptors
smelling odor step 2
olfactory sensory neurons are activated
smelling odor step 3
olfactory sensory neurons activate a specific region of the olfactory bulb that is is responsible for detecting chemicals structurally similar to the odor molecule sensed
capsaicin
active ingredient in chili peppers and pepper spray (contributes to spicy flavor/smell)
how is capsaicin nonpolar?
made up of hydrocarbon chains; causes the chemical to be hydrophobic ie. not dissolve well in polar solutions like water
which container between oil infused with chilli peppers and water infused with chili peppers would be more spicy and why?
oil infused with chili peppers; oil is a nonpolar solution meaning the molecules in the peppers would be more attracted to the oil molecules and fuse with them, while the pepper molecules would try to stay away from the polar water solution molecules
nocieption
the ability to feel pain; caused by stimulation of a nociceptor
what happens when capsaicin binds TRPV1?
receptors will respond to heat and produce burning pain sensations; gated by temperature and various chemical ligands
agonist
drug that mimics endogenous ligand and activates receptors, which enhances the activation/effect of endogenous ligand
antagonist
drug that blocks endogenous ligand/agonists from activating receptors, which inhibits their activation/effect