Pharmacy and Med Chem of insulin (Dr. Sharma)

insulin is required for glucose uptake through what

GLUT4 translocation

insulin receptor activation causes activation of tyrosine kinase which causes translocation of GLUT4 leading to what

glucose uptake

synthesized as a single chain peptide prohormone called what

proinsulin

cleaved by two cellular endopeptidases and pro hormone converts 2 into insulin and c peptide 

true 

the peptide is measured to evaluate B-cell secretory functions to assess insulin requirement, differential diagnosis between type 1 and type 2 diabetes and to understand the cause of hypoglycemia

true

ultra rapid acting aspart

ultra rapid lispro

ultra rapid acting

Humalog 

apidra 

Novolog 

rapid acting 

humulin R and novolin R is what

short acting

humulin N, Novolin N is what

intermediate

lantus, tujeo 

levemir

tresiba 

long acting 

human insulin complex with what

zinc

which ones are basal

intermediate and long acting

which ones are postprondial 

ultra rapid acting rapid acting and short acting 

• Onset of action is 30-60 minutes and duration of action 4-6 hours is what insulin

short acting regular insulin

Human insulin with changes in few amino acids in the insulin polypeptide chain which prevents the insulin molecules from forming what

dimers

• : Quicker onset of action and shorter duration of action compared to regular insulin

rapid acting insulin 

• Quicker onset of action (2.5 min) compared to aspart insulin (5 min) 

ultra rapid acting insulin

• Lispro insulin containing a oligosaccharide BioChaperone 222 (BC222) in its formulation which enhances lispro’s absorption from s.c space after injection

true 

• Two arginine residues are added to the C terminus of the B chain, and an asparagine molecule in position 21 on the A chain is replaced with glycine 

true