Clin-Chem Lab AA Part 5

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17 Terms

1

<p>What disease/ disorder is associated?</p>

What disease/ disorder is associated?

Monoclonal Gammopathy

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2

<p>What disease/ disorder is associated?</p>

What disease/ disorder is associated?

Polyclonal Gammopathy

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3

<p>What disease/ disorder is associated?</p>

What disease/ disorder is associated?

Nephrotic Syndrome

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4

<p>What disease/ disorder is associated?</p>

What disease/ disorder is associated?

Cirrhosis

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5

<p>What disease/ disorder is associated?</p>

What disease/ disorder is associated?

Alpha-1 Antitrypsin (AAT) Deficiency

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6

<p>What disease/ disorder is associated?</p>

What disease/ disorder is associated?

Acute Inflammation

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7

<p>What disease/ disorder is associated?</p>

What disease/ disorder is associated?

Chronic Inflammation

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8

<p>What disease/ disorder is associated?</p>

What disease/ disorder is associated?

Hypogammaglobulinemia

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9

• Multiple Myeloma, Waldenstrom’s Macroglobulinemia

• Sharp, tall M-spike in gamma region

• Excess monoclonal IgG or IgA

• Other proteins:

• Normal or decreased albumin

Monoclonal Gammopathy

<p>Monoclonal Gammopathy</p>

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10

• Chronic infection, Liver Disease

• Broad, diffuse increase in gamma region

• Polyclonal Ig production

• Other conditions:

• Chronic liver disease

• Autoimmune disorders

Polyclonal Gammopathy

<p>Polyclonal Gammopathy</p>

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11

• Decreased albumin

• Protein loss in urine

• Increased Alpha-2 globulin

• Alpha-2 macroglobulin retention

• Other proteins:

• Beta and gamma regions may be reduced

Nephrotic Syndrome

<p>Nephrotic Syndrome</p>

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12

• Liver Disease

• Betta-gamma bridging

• Fusion of betta and gamma bands due to increased IgA

• Other Proteins:

• Decreased albumin due to impaired liver synthesis.

Cirrhosis

<p>Cirrhosis</p>

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13

• Marked decreased or absence of the Alpha-1 globulin band.

• Conditions:

• Liver disease

• Genetic disorder

Alpha-1 Antitrypsin (AAT) Deficiency

<p>Alpha-1 Antitrypsin (AAT) Deficiency</p>

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14

• Immediate response pattern

• Increased alpha-1 and alpha-2 globulin fractions.

• Albumin may be slightly decreased due to negative acute response.

• Conditions:

• Acute infections

• Burns

• Trauma

• Acute phase reactions

Acute Inflammation

<p>Acute Inflammation</p>

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15

• Delayed response pattern

• Increased alpha-1, alpha-2 globulin and globulin fractions.

• Albumin may be slightly decreased due to negative acute response.

• Conditions:

• Chronic infections

• Autoimmune disease

Chronic Inflammation

<p>Chronic Inflammation</p>

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16

• Marked decrease or absence of gamma-globulin band

• Normal levels of albumin, alpha and beta globulins.

• Conditions:

• Primary and secondary immunodeficiency

Hypogammaglobulinemia

<p>Hypogammaglobulinemia</p>

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17

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