space between the metaphysis and epiphysis -only in living individuals, seen in X-Rays
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Metaphysis
where diaphysis and epiphysis meet
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Collagen in bone
type 2
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Osteoblasts
build bone by secreting osteoid
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osteoid
unmineralized bone matrix
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Osteoclasts
clear away/break bone -repair via remodelling
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Osteocytes
mature bone cells -osteoblasts trapped in bone matrix
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Lacunae
pores that contain osteocytes
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Function of osteocytes
bone maintenance and communication -respond to need for more/less minerals -alert BMU to damaged bone
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Layers of bone
periosteum and endosteum
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Periosteum
fibrous membrane covering a bone
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Endosteum
lining of the medullary cavity
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Lamellar bone
mature bone
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lamellae
sheets of mature bone, 3-7 microns thick
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Haversian canal
central, longitudinal canals of bone that carry blood vessels and nerves to deliver nutrients and signals through bone matrix
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Osteon
basic unit of lamellar bone -Includes osteocyte, haversian canal, and circular sheets of lamellae
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Volkmann's Canals
transverse canals that connect Haversian canals, also carry blood vessels and nerves
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endochondral ossification
process in which bone forms by replacing hyaline cartilage 1. Bone collar formation 2. Calcification of cartilage, cavitation begins 3. spongy bone forms in center shaft 4. Medullary cavity forms, SOCs appear, ossification continues 5. Ossification of epiphyses, hyaline cartilage only remains in epiphyseal plate and articular cartilage
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intramembranous ossification
bone develops from a fibrous membrane 1. Mesenchymal stem cells differentiate into osteoblasts and form ossification center 2. Osteoid secreted and calcifies which traps osteoblasts to become osteocytes 3. Osteoid laid in random pattern, forms woven bone. Mesenchyme condenses on outer layer of woven bone and becomes periosteum 4. Lamellar bone replaces woven bone forming compact bone sheets and red marrow appears
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Types of bones
compact (dense/cortical) and spongy (trabecular/cancellous)
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functions of skeleton
Hematopoiesis, mineral/fat storage, support, protection, movement
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stored in medullary cavity, mostly fat
yellow marrow
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stored within cancellous tissue
red marrow
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minerals in bone
mostly calcium and phosphate
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Trabecular bone makes up
flat bones, articular ends of long bones
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Compact bone makes up
external surfaces of bone, shaft of long bone
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Bones longer than they are wide
long bone
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generally cube shaped bones, or bones that form within tendons
short bones
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thin, flattened and slightly curved bones
flat bones
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bones with complicated shapes
irregular bones
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Long bones make up the
appendicular skeleton
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short bone examples
carpals, tarsals, and patella
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flat bone examples
skull, ribs, sternum, and pelvis
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irregular bone examples
vertebrae, mandible and parts of the splanchnocranium