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bimodal release
two doses, one is immediate and the other is delayed
Extended Release Advantages
less fluctuation in concentration
reduced dosing frequency
convenience and compliance
reduced adverse effects
Delayed Release Advantages
protection from gastric fluids
reduced gastric distress
MRDF Disadvantages
not for all drugs
not for all patients
cost
less flexibility in dose
dose dumping risk
dose dumping
sudden and total release of drug due to a technology failure
0.5-1 g
appropriate drug dose
4-6 h
desired half life for MRDF
Class II and IV
bad BCS classes for MRDF
dissolution controlled dosage forms
coated beads and granules
microencapsulated drug
multitablet system
complex formation
diffusion-dissolution controlled dosage forms
hydrophilic matrix systems
diffusion controlled dosage forms
insoluble polymer matrix
membrane-controlled systems
coated microspheres
a dosage form where the drug is distributed on beads or granules and surrounded by a lipophilic coating to control dissolution rate
microencapsulated drug
a dosage form where microscopic particles of drug are coated with gelatin which allows enhanced absorption in the GI tract
multitablet system
a dosage form where 8-10 minitablets are inside a gelatin capsule
complex formation
a dosage form that consists of a drug and other agents
hydrophilic matrix system
a dosage form that consists of a drug and water-swellable polymer compressed into a tablet
insoluble polymer matrix
a dosage form that consists of a drug in an inert polymer that does not disintegrate and will appear in stool
membrane-controlled systems
a dosage form that consists of a drug core coated in an insoluble polymer
osmotic pump system
a dosage form with a core tablet surrounded by a semi-permeable membrane coating with a laser hole
ion-exchange resin
a dosage form consisting of a resin-drug complex with basic or acidic groups that form ionic complexes
enteric coated system
a dosage form where the drug is coated in a gastro-resistant polymer that slowly erodes
colonic drug delivery
a dosage form where the drug is coated in a film that is insoluble in GI fluids and can only be digested by colonic bacteria
proton pump inhibitors
delayed release drug affected by food in the stomach
Note 
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