Immunoglobulins

IgM

• Pentamer

• First produced

• Short-lived

• Cannot cross placenta

IgG

• Second produced

• More robust (get more of it)

• Longer lasting

• Can cross placenta

IgA

• Monomer

• Most abundant (blood and tissues)

• Longest protection per half life (more bang for your buck)

• Direct Protection

Direct Protection of IgA

• Neutralizes viruses & toxins

• Immobilizes motile organisms

• Prevents microbes from adhering to cell surfaces and cross-linking to antigen

IgD

Developments and maturation of Ab response

IgE

• Binds via Fc region to mast cells and basophils

• Allows mast cells and basophils to detect parasites and other Ag and responds by releasing their granule contents

• Involved in many allergic reactions

Which immunoglobulin is the largest and first produced?

IgM

Which immunoglubulin can cross the placenta: IgM or IgG?

IgG

What immunoglobulin supplies the longest protection per half-life?

IgA

IgG is produced ___________

second

IgG has the most __________ response

robust

IgM has a ________ structure

pentamer

Ig-A has a __________ structure

monomer

Which immunoglobulin binds to Fc portion on mast cells and basophils?

IgE

IgE is involved in _____________________

allergic reactions

IgA involves ______ protection

direct