Physio Nephron Transporters

SGLT location on nephron

PCT, luminal side

SGLT direction of ion movement

Cotransport of Na and glucose into tubular cells

Na-amino acid cotransporter location on nephron

PCT, luminal side

Na-amino acid cotransport direction of ion movement

Cotransport of Na and amino acids into tubular cells

GLUT location on nephron

PCT, basolateral side

GLUT direction of ion movement

Glucose diffusion into ISF

NHE (Na/H countertransorter) location on nephron

PCT and Thick ascending loop, luminal membrane

NHE direction of ion movement

Na into tubular cells, H into tubule lumen

Factors affecting Na/H countertransporter (NHE)

AT-II stimulates NHE on luminal side of PCT, increasing Na reabsorption and H secretion

Na/K ATPase location on nephron

Basolateral membrane of PCT, thick ascending loop, early distal tubule, principal cells

Na/K ATPase direction of ion movement

3 Na into ISF, 2 K into tubular cells

Factors affecting Na/K pump

AT-II stimulates the pump

Na/HCO3 cotransporter location on nephron

PCT, basolateral side

Na/HCO3 cotransporter direction of ion movement

Transport of Na and Bicarb into ISF

Factors affecting transport of Na/HCO3 cotransporter

AT-II

Na transporters found on the luminal side of the PCT

H --> Na/H exchanger (NHE)

A --> Na/Amino acid cotransporter

G --> Na/Glucose cotransporter (SGLT)

Think the PCT is a HAG for sodium

Na transporters found on the basolateral side of the PCT

G --> GLUT

K --> Na/K pump

N --> Na/HCO3

Think the basolateral side Gives Kind Nutrients to the body

NKCC2 cotransporter location on nephron

Thick ascending loop, luminal membrane

NKCC2 direction of ion movement

Na, Cl, and K into tubular cells from lumen

Cl channels found on which part of the nephron

Basolateral membrane of thick ascending loop, early distal tubule, type B intercalated cells

Cl channels direction of ion movement

chloride diffusion into ISF

What kind of channel/transporter are found on the luminal side of type A intercalated cells

Cl channels

How do ions move through Cl channels that are found on type A intercalated

Cl diffuses into the lumen

What kind of transporter is found in the early distal tubule specifically on the luminal membrane

Na-Cl cotransporter (NCC)

Na-Cl (NCC) cotransporter direction of ion movement

Sodium and chloride into tubular cells from lumen

Factors affecting Na-Cl (NCC) cotransporter

AT-II

What type of channels/transporter are found on the luminal surface of principal cells?

K channels, and Na channels

K channels direction of ion movement in principal cells

K diffusion into lumen

Factors affecting K channels?

Aldosterone

Na channels direction of ion movement in principal cells?

Na diffusion into tubular cells from lumen

Factors affecting Na channels

Aldosterone

On which surface can we find the Na/K pump in principal cells?

Basolateral membrane

Factors affecting Na/K pump in principal cells

Aldosterone and AT-II

H ATPase Pump location on nephron

Type A intercalated, luminal side

H ATPase pump direction of ion movement

H transport into lumen

H-K ATPase Pump location on nephron

Type A intercalated, luminal side

H-K ATPase pump direction of ion movement

H transport into lumen, K transport into tubular cells

HCO3/Cl countertrasnporter location on nephron

Type A intercalated cells on the basolateral surface

HCO3/Cl countertransporter direction of ion movement?

HCO3 transport into ISF, Cl transport into tubular cells

K channels found on basolateral membrane of which cells?

Type A intercalated cells

K channels on type A intercalated cells direction of ion movement

K diffusion into ISF

HCO3/Cl Countertransporter found on luminal side of which cells?

Type B intercalated cells

Direction of ion movement in type B intercalated cells through the HCO3/Cl countertransporter ?

HCO3 transport into lumen, Cl transport into tubular cells

What transporters are found on the basolateral membrane of type B intercalated cells?

H ATPase pump

H-K ATPase pump

Cl channels

Direction of ion movement in type B intercalated cells through H ATPase pump

H transport into ISF

Direction of ion movement in type B intercalated cells through H-K ATPase pump

H transport into ISF, K transport into tubular cells

Aquaporins location on nephron

Late distal tubule, collecting tubules, collecting ducts

Aquaporins direction of ion movement

osmosis of water from lumen into ISF

Factor affecting aquaporins

ADH

What kind of transporters are found on the luminal surface of Type A intercalated cells

H ATPase pump

Cl Channel

H-K ATPase

List the transporters found on the basolateral surface of type A intercalated cells

HCO3/Cl countertransporter and K channels

List the transporters found on the luminal surface of type B intercalated cells?

HCO3/Cl countertransporter, and K channel

List the transporters found on the basolateral surface of type B intercalated cells?

H ATPase pump

H-K ATPase pump

Cl channel

List the transporters that can be stimulated by Angiotensin II

NHE

Na/K Pump

Na/HCO3 cotransporter

Na-Cl cotransporter

List the transporters that can be stimulated by Aldosterone

Works on Principal cells

K channels

Na channels

Na/K pump