Immunology & Serology - Lecture - 5 - Complement System - Part 4 - Receptors on cell membranes for complement components - Complete

CR1 (CD35)

This complement receptor is found on RBCs, neutrophils, monocytes, macrophages, eosinophils, B and T cells, and follicular dendritic cells.

CR1 (CD35)

The function of this complement receptor serves as a cofactor for factor I;

CR1 (CD35)

The function of this complement receptor is to mediate transport of immune complexes

C3b, iC3b, C4b

What are the ligands of CR1 (CD35)?

CR2 (CD21)

This complement receptor is found on B cells, follicular dendritic cells, and epithelial cells

CR2 (CD21)

The complement receptor acts a B-cell coreceptor for antigen with CD19

C3dg, C3d, iC3b

What are the ligands of CR2 (CD21)?

CR3 (CD11b-CD18), CR4 (CD11c/CD18)

These complement receptors serve as adhesion and increased activity of phagocytic cells

CR3 (CD11b-CD18)

This complement receptor can be found on monocytes, macrophages, neutrophils, NK cells

iC3b, C3d, C3b

What are the ligands of CR3 (CD11b-CD18)?

CR4 (CD11c/CD18)

This complement receptor can be found on monocytes, macrophages, neutrophils, NK cells, activated cells T and B cells, and dendritic cells

iC3b, C3b

What are the ligands of CR4 (CD11c/CD18)?

DAF (CD55)

This complement receptor dissociates C2b or Bb from binding sites

DAF (CD55)

This complement receptor prevents the formation of C3 convertase

DAF (CD55)

This complement receptor can be found on RBCs, neutrophils, platelets, monocytes, endothelial cells fibroblasts, T cells, B cells, and epithelial cells

C3b, C4b

What are the ligands of DAF (CD55)?

MIRL (CD59)

This complement receptor can be found on RBCs, neutrophils, platelets, monocytes, endothelial cells, and epithelial cells

MIRL (CD59)

This complement receptor prevents the insertion of C9 into cell membrane

C8

What is the ligand of MIRL (CD59)?

MCP (CD46)

This complement receptor can be found on neutrophils, monocytes, macrophages, platelets, T cells, B cells, and endothelial cells

MCP (CD46)

This complement receptor is a cofactor for factor I cleavage of C3b and C4b

C3b, C4b

What are the ligands of MCP (CD46)?