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Strong Nucleophile/Weak Base

Strong Nucleophile/Strong Base

Weak Nucleophile/Weak Base

SN2 Only
Strong Nucleophile/Weak Base and Methyl Substrate
SN2 Only
Strong Nucleophile/Weak Base and Primary Carbon Substrate
SN2 (slower)
Strong Nucleophile/Weak Base and Secondary Carbon Substrate
No Reaction
Strong Nucleophile/Weak Base and Tertiary Carbon Substrate
SN2 Only
Strong Nucleophile/Strong Base and Methyl Substrate
SN2 (major) + E2 (minor)
Strong Nucleophile/Strong Base and Primary Carbon Substrate
SN2 (minor) + E2 (major)
Strong Nucleophile/Strong Base and Secondary Carbon Substrate
E2 only
Strong Nucleophile/Strong Base and Tertiary Carbon Substrate
No Reaction
Weak Nucleophile/Weak Base and Methyl Substrate
No Reaction
Weak Nucleophile/Weak Base and Primary Carbon Substrate
SN1 +E1 (slow)
Weak Nucleophile/Weak Base and Secondary Carbon Substrate
SN1 +E1 (faster)
Weak Nucleophile/Weak Base and Tertiary Carbon Substrate