Injectable drug cards: Dosage range/uses

Dosage range/use for Mucosil

For the treatment of acetaminophen overdose:

21 hr regimen: Give IV loading dose of 150 mg/kg in 200 mL D5W over 60 minutes, maintenance dose is 50 mg/kg in 500 mL D5W over 4 hrs, then double it over 16 hrs

48 hr regimen: Give IV loading dose of 140 mg/kg (diluted in 1:5 D5W) over 60 minutes. After 4 hours give 70 mg/kg in same dilution every 4 hrs for 12 doses for a total of 980 mg/kg.

For nephrotoxic prophylaxis: 1200 mg IV before procedure, followed by 1200 mg orally twice daily for 2 days.

For the treatment of atelectasis: 3-5 mL of 20% solution or 6-10 mL of the 10% solution 3-4 times daily. Dosage range is 1-10 mL of 20% solution or 2-20% of the 10% solution every 2-6 hours.

Dosage range/uses for Zovriax

Neonates (birth- 3 months): 10 mg/kg/dose every 8 hrs for 10 days; 15-20 mg/kg/dose every 8 hours for 14-21 days.

Children < 12 years: 10-20 mg/kg/dose every 8 hours for 7-10 days OR 250 mg/m^2/dose every 8 hours or 125 mg/m^2/dose every 6 hours.

12 and older: 5-10 mg/kg/dose every 8 hours for 7-21 OR 500 mg/m^2/dose every 8 hours for 7-21 days.

Dosage range/uses for Adenoscan

Usual dose for patients under 50 kg: 0.05-0.1 mg/kg, may repeat in 1-2 minutes and increase dose by 0.05-0.1 mg/kg. May repeat until sinus rhythm is established or to maximum single dose of 0.3 mg/kg or 12 mg.

Usual dose for adults over 50 kg: 6 mg, if no effect in 1-2 minutes, 12 mg may be given. May repeat single bolus dose of 12 mg.

For stress testing: Continuous IV infusion of 140 mcg/kg/min for 6 minutes.

Acute vasodilator testing: 50 mcg/kg/min increased by 50 mcg/kg/min every 2 minutes until maximum dose is achieved

Dosage range/uses for Alteplase, Recombinant

For coronary artery thrombi and heart attack: Usual adult dosage is 100 mg administered over a 3 hr period.

For acute pulmonary embolism: Usual dosage is 100 mg IV over a 2 hr period.

For arterial thrombosis and embolism: Usual dose is 2 mg/hr for up to 5 hrs.

Restoration of function of central venous access device: Used in dysfunctional catheter at a concentration of 1 mg/mL. Give up to 2 mg and leave catheter in for 0.5-2 hrs, may repeat one time.

Dosage range/use for Amikin

The usual IM or IV dose in adults, children, and older infants with normal renal function is 20 mg/kg administered in a single dose. Recommended loading dose for neonates is 10 mg/kg followed by 7.5 mg/kg every 12 hrs.

Peak and trough serum concentrations at steady state should be monitored with desired peaks ranging from 15-20 mcg/mL and troughs in the 5-10 mcg/mL range.

Therapeutic Peak Drug Level: 16-25 mcg/mL, through 1-8 mcg/mL; toxic peak concentrations: > 35 mcg/mL. Draw peak 30 minutes after completion of infusion and trough 30 mins before next infusion.

Dosage ranges/use for Cordarone

For the treatment and prophylaxis of frequent recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy.

Loading dose: Give 150 mg over the first 10 minutes (add 3 mL in 100 mL D5W). Follow with a slow infusion of 360 mg over 6 hrs ( add 18 mL in 500 mL D5W). Dosage must be individualized.

Maintenance dose: Infuse 0.5 mg/min (720 mg/24 hrs) for up to 3 weeks.

Breakthrough episode dose: Infuse 150 mg over 10 minutes.

Therapeutic concentration: 1-2.5 mg/mL

Dosage range/use for Amphotericin B

Usually empiric based on patient tolerance and infection. Must be administered slowly by IV infusion to prevent potentially serious ADRs. Doses are usually initiated with a dose of 0.25 mg/kg over a 6 hour period. Some sources recommend an initial dose of 1 mg over 20-30 minutes before regular therapy is initiated. The daily dose should be gradually increased, generally in 5 mg increments, until desired dose is reached. Should never exceed 1.5 mg/kg/day. Duration of therapy may vary depending on the nature and severity of the infection, but may last up to several months.

Dosage range/use for Principen

For GI infections, UTIs, URIs, and all skin infections: Adults 500-1000 mg IV/IM every 6 hrs, may increase up to 14 g/day. Children < 20 kg and infants: 100-200 mg/kg/day IV/IM in equal doses every 4-6 hrs. Neonates 50-100 mg/kg/day IV/Im every 6-12 hrs.

Severe infections, including those of bone, meningitis, and pneumonia: Adults and children > 20 kg: 150-200 mg/kg/day IV/IM in equal doses every 3-4 hrs, max daily dose is 14 g/day. Children <20 kg and infants: 100-200 mg/kg/day in divided doses every 4-6 hrs, max of 12 g/day. Neonates: 50-100 mg/kg/day every 6-12 hrs.

Prophylaxis of group B streptococci in neonates: Give 2 g IV to mother about 4 hrs before delivery, then 1-2 g IV every 4-6 hrs until delivery

Bacterial endocarditis prophylaxis: 2 g IV/IM, 30 minutes before procedure.

Dosage range/use for Unasyn

For the treatment of skin and skin structure infections due to beta-lactamase producing strains of S. aureus, E. coli, Klebsiella species, P. mirabilis, B. fragilis, Enterobacter species, and A. calcoaceticus.: 1.5 - 3 g given either IV or IM route every 6 hours.

For the treatment of intra-abdominal infections caused by beta-lactamase producing strains listed above: Same dosing

For the treatment of gynecological infections caused by beta-lactamase producing strains of E. coli and Bacteroides species: Same dosing

Pediatric patients: 300 mg/kg given by IV every 6 hrs

Dosing in renal impairment when CrCl is 15-29 mL/min: decrease dosing to every 12 hrs.

Dosing in renal impairment CrCl 5-14 mL/min: decrease dosing to every 24 hrs

Dosage range/use for Sal-Atropine

To inhibit salivation secretions:

Children < 5 kg: 0.02 mg/kg/dose 30-60 minutes preoperatively then every 4-6 hrs as needed. Doses <0.1 mg can cause paradoxical bradycardia in neonates, infants, and children.

Children > 5 kg: 0.01-0.02 mg/kg/dose to a maximum 0.04 mg/kg/dose 30-60 minutes preoperatively. Minimum dose is 0.1 mg

Bradycardia IV or intrathecal:

Children: 0.02 mg/kg, minimum dose of 0.1 mg, maximum single dose 0.5 mg in children and 2 mg in adolescents

Adults: 1 mg IV, repeat in 3-5 minutes if asystole persists. Total dose of 0.04 mg/kg. Intrathecally administer 2-2.5 times recommended IV dose, dilute in 10 mL of saline or DW

Dosage range/use for Zithromax

Community-acquired pneumonia: 500 mg IV as a single daily dose for 2 or more days followed by oral therapy of 500 mg daily for 7-10 days.

Pelvic inflammatory disease caused by gonhorreae, chlamydia, or M. hominis: 500 mg IV for 1-2 days followed by 250 mg orally for 7 days.

Dosage range/use for Aztreonam

Treatment of lower respiratory tract infections, skin/skin structure infections, intra-abdominal infections (peritonitis), and gynecologic infecections: cause by susceptible Gram-negative bacteria: 1-2 g every 8-12 hrs.

For the treatment of complicated/uncomplicated UTIs: 500mg -1 g every 12 hrs

For the treatment of moderately severe systemic infections: Adults should receive 1-2 g every 8-12 hrs. Severe life threatening infections involving P. aeruginosa may require 2 g every 6 hrs, max dose is 8g/day

Pediatric dosage (1 mo - 15 years): 30-50 mg/kg every 4-8 hrs.

Dosage range/use for Bumetanide

For the management of edema: Inital dose is 0.5-1 mg IV or IM, may be given every 2-3 hrs if necessary. Max daily dose is 10 mg.

Pediatric dosage: 0.015-0.1 mg/kg daily can be used in patients with CHF

Dosage range/use for Buprenex

For management of severe pain in adults and children older than 13 years of age: 0.3 mg every 6 hours, initial dose may be repeated once in 30-60 minutes if necessary. Doses of 0.6 mg (IM only) and reduced intervals of 4 hrs have been used in patients with less risk for complications.

Children 2-12 years old: 2-6 mcg/kg every 4-6 hours have been used. Maximum daily dose is 0.6 mg IM and 0.3 mg IV

Dosage range/use for Butorphanol

Adult dose: 2 mg IM or 1 mg IV which may be repeated every 3-4 hrs as necessary. Usual effective dose is 1-4 mg IM or 0.5- 2 mg IV depending on severity of pain.

Dosage range/use for Cancidas

Empiric therapy: 70 mg on day 1, then 50 mg/day which may increase up to original 70. Patients on rifampin, carbamazepine, dexamethasone, efavirenz, nevirapine, or phenytoin should receive 70 mg/day. No adjustment is needed for renal impairment. For liver impairment 70 mg should be given initially , then give 35 mg/day after.

Dosage range/use for Ancef

Used in the treatment of respiratory tract, biliary tract, genitourinary tract, skin/skin structure infections, bone/joint infections, septicemia, or endocarditis: 250 mg - 2 g every 6-12 hrs given IV or IM. Severe life-threatening infections may require 12 g daily.

Usual pediatric dosage: 25-100 mg/kg/day divided every 6-8 hrs with a max of 6 g/day

Dosage range/use for Cefepime

1.) Moderate/severe pneumonia: 1-2 g IV every 12 hrs for 10 days.

2.) Empiric therapy for febrile neutropenic patients: 2 g IV every 8 hrs for at least 7 days.

3.) Mild/moderate uncomplicated or complicated UTIs: 0.5-1 g IV or IM (E. coli only) every 12 hrs for 7-10 days.

4.) Severe UTIs: 2 g IV every 12 hrs for 10 days.

4.) Complicated intra-abdominal infections (use with Flagyl): 2 g IV every 12 hrs for 7-10 days.

CrCl 30-60 mL/min: 1.) 500 mg/24 hrs, 2.) 1 g/12 hrs, 3.) 2 g/12 hrs, 4.) 2 g/8 hrs

CrCl 11-29 mL/min: 1.) 500 mg/24 hrs, 2.) 500 mg/24 hrs, 3.) 1 g/24 hrs, 4.) 2 g/24 hrs

CrCl < 11: 1.) 250 mg/24 hrs, 2.) 250 mg/24 hrs, 3.) 500 mg/24 hrs, 4.) 1 g/24 hrs

CAPD: 1.) 500 mg/48 hrs, 2.) 1 g/48 hrs, 3.) 2 g/48 hrs, 4.) 2 g/48 hrs

Hemodialysis: 1 g on day 1, THEN 500 mg/day after

Dosage range/use for Claforan

For a variety of soft tissue infections: 1 gram every 6-8 hrs. Uncomplicated infections usually respond to 1 gram/12 hrs. Severe infections should be given 2 g every 4 hrs.

Preoperative prophylaxis: 1 g may be given 30-60 minutes prior to surgery.

Neonates: 50 mg/kg every 12 hrs

Neonates 1-4 weeks old: 50 mg/kg every 6-8 hrs

Children less than 50 kg (1 month-12 yrs): 50-200 mg/kg daily in 3-6 doses.

Dosage range/use for Ceftriaxone

Children 12 yrs-adult: 1-2 g given orally once daily, doses of 4 g may be needed for CNS infections.

Neonates and children < 12: 50-75 mg/kg daily in divided doses every 12 hrs. 100 mg/kg is recommended for CNS infections.

Dosage reductions are not needed for renal impairment.

Dosage range/use for Cefuroxime

For treatment of complicated UTIs, skin infections, disseminated gonococcal infections, and uncomplicated pneumonia in adults: 750 mg-1.5 g every 8 hrs

For the treatment of severe complicated bone/joint infections: 1.5 g every 8 hrs

For the treatment of bacterial meningitis in adults: 3 g every 8 hrs.

Pediatric dosage: 50-150 mg/kg daily every 6-8 hrs, maximum dose is 6 g/day

Reductions may be needed in those with renal impairment.

Dosage range/use for Thorazine

Adult parenteral dose: 25-50 mg and may be repeated every hour for acute symptoms. Titration should be based on response with a maximum dose of 400 mg every 4-6 hrs. Usual dose is 300-800 mg/day

Nausea and vomiting: 25-50 mg every 4-6 hrs

For relief of apprehension and anxiety during surgery: 12.5-25 mg given 1-2 hrs before surgery.

Child behavior disorders: 0.5-1 mg/kg every 6-8 hrs with a maximum IM dose of 40-75 mg/day based on age and weight.

Nausea and vomiting in children: 0.5-1 mg/kg

Dosage range/use for Cidofovir

Induction: 5 mg/kg IV over 1 hr once weekly for 2 consecutive weeks

Maintenance: 5 mg/kg IV over 1 hr every other week

Give 2 g probenecid orally 3 hrs before each infusion and 1 g at 2 hrs and 8 hrs post-infusion.

If SCr increases by more then 0.3-0.4 mg/dL, decrease dose to 3 mg/kg

Use with caution in existing renal impairment.

Dosage range/use for Cipro I.V.

Adult dose for uncomplicated UTIs: 200 mg IV every 12 hrs for 1-2 weeks.

All other infections: 400 mg every 12 hrs for 1-2 weeks.

Bone and joint infections: 400 mg every 12 hrs for 4-6 weeks

Dosage and frequency may require reductions in renal impairment.

Dosage range/use for Cisplatin

Bladder cancer: 50-70 mg/m2 IV as a single dose once every 3-4 weeks in combination with other agents.

Malignant mesothelioma: 75 mg/m2 over 2 hrs with pemtrexed over 10 minutes on day 1 of 21 day cycle. Give 30 minutes after end of infusion.

Ovarian cancer: 50-75 mg/m2 once ever 21 days in combination with cyclophosphamide or paclitaxel.

Treatment of testicular cancer: 60 mg/m2 as a single dose on days 23 and 30 of a 60 day regimen with other agents.

Dosing varies, if dose is over 100 mg/m2 consult oncologist. Adjust if CrCl is < 50 mL/min

Dosage range/use for Clindamycin

Usual dose is 1.2-1.8 g daily given in 2-4 doses. Single doses should not exceed 600 mg and no more than 1.2 g in a single hour.

Adult life-threatening infections: 4.8 g daily.

Children > 1 month: 15-40 mg/kg daily in 3-4 doses

Neonates: 15-20 mg/kg daily.

Acute PID: 900 mg every 8 hrs for 4 days.

Prophylactic bacterial endocarditis: 600 mg IV 30 minutes before procedure, followed by 150 mg IV or orally 6 hrs later.

Dosage range/use for Dantrolene

For the treatment of spasticity associated with spinal cord injury, stroke, cerebral palsy, or MS: 2.5-5 mg/kg approximately 1.25 hours prior to anesthesia and infused over 1 hour. May repeat dose up to 10 mg/kg

Dosage range/use for Cubicin

For the treatment of skin/skin structure infections caused by susceptible strains of gram-positive S. aureus, S. pyogenes, S. agalactiae, S. dysgalactiae, and E. faecialis (vancomycin-susceptible strains only): 4 mg/kg over 30-minute period by IV infusion once daily for 7-14 days.

Dosing when CrCl < 30 mL/min, inculding hemodialysis or CAPD: Administer 4 mg/kg once every 48 hrs.

Dosage range/use for Darbepoetin Alfa

For the treatment of anemia associated with chronic renal failure: 0.45 mcg/kg, administered as single IV or SC injection once a week. Because of individual variability, doses should be titrated to not exceed a target hemoglobin concentration of 12 g/dL.

Maintenance doses can be less than starting dose and some patients have been treated successfully with an every other week dosing. Dosage increases should not occur more frequently than every 4 weeks. If hemoglobin increases by more than 1.0 g/dL in a 2-week period, decrease the dose by 25%.

For the treatment of anemia in patients with non-myeloid malignancies due to chemotherapy: 2.25 mcg/kg administered as a weekly SC injection.

If hemoglobin increases by more than 1.0 g/dL in a 2 week period or concentration exceeds 12 g/dL

Dosage range/use for Dalalone

For the treatment of shock: 1-6 mg/kg as a single injection, or 40 mg initially followed by repeated doses every 4-6 hrs. Alternative therapy recommended may be an initial bolus of 20 mg, followed by infusion rate of 3 mg/kg/day.

For cerebral edema: An initial dose of 10 mg followed by 4 mg every 6 hrs is recommended with dosage reductions after 2-4 days, the dose should be tapered over next 5-7 days.

As an adjunct to prevention of chemotherapy-induced emesis: 10-20 mg may be given before administration of the agent.

Bacterial meningitis in infants/children: 0.15 mg/kg for first 4 days of antibacterial therapy.

Dosage range/use for Diazepam

Severe anxiety: 2-10 mg, may be repeated hourly (max, 30 mg in 8 hr period)

Light anesthesia and anterograde amnesia for procedures: 5-20 mg may be given approximately 30 minutes prior to initiation

Skeletal muscle relaxation/anticonvulsant action: 5-10 mg initially, and may be repeated ever 3-4 for muscle relaxation or 10-15 minutes for seizures.

Children: 0.04-3 mg/kg repeated every 2-4 hrs, but not to exceed 0.6 mg/kg in 8 hrs.

Opiate withdrawal anxiety: 0.5-2 mg IM every 8 hrs

Dosage range/use for Lanoxin

Full digitalization in adults with normal renal function, loading dose: 8-12 mcg/kg are usually administered by giving 50% of the total dose as the first dose, then 25% at 8 hrs.

Daily % loss = 14 + CrCl(mL/min)/5

Pediatric and neonate digitalization doses: 15-50 mcg/kg based on age, with maintenance doses generally 20-35% of loading dose.

Therapeutic drug level: 0.5-2 ng/mL

Dosage range/use for DIltiazem

For atrial flutter/fibrillation or paroxysmal supraventricular tachycardia: bolus dose of 0.25 mg/kg (20 mg) given with a repeat dose of 0.35 mg/kg (25 mg) in 15 minutes if needed.

Constant control of heartrate: 10 mg/hr (range of 5-15 mg) for up to 24 hrs.

Severe hypertension: continuous infusion of 10 mcg/kg/min has been reported effective.

Dosage range/use for Benadryl

Usual adult dose is 10-50 mg given at 4-6 hour intervals with maximum adult dose being 400 mg/day

Children: 5 mg/kg or 120 mg/m2 given IV/IM daily given in 3-4 doses with maximum dose being 150 mg/day.

Dosage range/use for Dobutamine

Administered by IV infusion using infusion pump or other device to control rate of flow. Concentrate for injection must be diluted before infusion to a maximum concentration of 5 mg/mL. Monitor HR, BP, urine output, cardiac output, and central venous pressure.

Increase cardiac output: 2.5-20 mcg/kg/min with a dose as high as 40 mcg/kg/min.

Dosage range/use for Anzemet

Prevention of nausea and vomiting caused by chemotherapy:

Children 2-16: 1.8 mg/kg approximately 30 mins prior to chemo (max: 100 mg/day)

Adults: 1.8 mg/kg or 100 mg given 30 minutes before chemo

Prevention of post-op nausea and vomiting:

Children 2-16: 0.35 mg/kg (max 12.5 mg) approximately 15 minutes before stopping anesthesia OR as needed.

Adults: 12.5 mg approximately 15 mins before stopping anesthesia.

Dosage range/use for Intropin

Used to increase cardiac output, BP, urine output in cases of shock, primarily cardiogenic and in short term management of patients with severe CHF. Normal infusion rate is 1-5 mcg/mg/min, which may be titrated at 10 and 30 minute intervals up to a final rate of 20-50 mcg/kg/min.

Severe circulatory decompensation: 20-50 mcg/kg/min (monitor urine output)

Dosage range/use for Doripenem

Treatment of intra-abdominal infections and UTIs including pyelonephritis: 500 mg every 8 hrs for 5-14 days.

Dose in renal impairment (CrCl < 50 mL/min): 250 mg every 8-12 hrs.

Dosage range/use for Doxycycline

Adult and children > 8: 200 mg the first day given in 1-2 doses, followed by 50-100 mg every 12 hrs.

Children < 45 kg: 4.4 mg/kg the first day, then 2.2-4.4 mg/kg daily thereafter.

Dosage range/use for Droperidol

Adult: 2.5-10 mg IV or IM given 30-60 minutes prior to the induction of general anesthesia, or for diagnostic procedures.

Adjunct for general anesthesia: 0.22-0.275 mg/kg may be given with analgesic.

Children 2-12 years old: 0.088-0.165 mg/kg IV or IM

Dosage range/use for Drotrecogin Alfa

Normal dose in sepsis is 24 mcg/kg/hr for a total of 4 days, STOP if bleeding occurs.

Dosage range/use for Vasotec

Usual dose for patients not receiving a diuretic is 1.25-5 mg every 6 hrs.

Patients on diuretics: 0.625 mg every 6 hrs and should be titrated based on response.

Patients with CrCl < 30 mL/min: Initially 0.625 mg with maintenance doses of 1.25 mg every 6 hrs.

Dosage range/use for Lovenox

For DVT prophylaxis after hip/knee replacement: 30 mg every 12 hrs beginning 12-24 hrs after operation and continue for 7-10 days. May use 40 mg once daily for 3 weeks post-op

For prophylaxis of DVT after abdominal surgery: 40 mg daily beginning 2 hrs before surgery and continue for 7-10 days post-op.

For treatment of DVT with/without PE: 1 mg/kg every 12 hrs or 1.5 mg/kg once daily.

Dosage range/use for Epinephrine

For the treatment of anaphylaxis or asthma: 0.1-0.5 mg given SQ or IM, repeat dose every 10-15 mins for anaphylaxis or 20 min-4 hr intervals for asthma.

Severe anaphylactic shock: 0.1-0.25 mg IV and repeated every 5-15 minutes as necessary.

Cardiopulmonary resuscitation: 0.5-1 mg given IV, endotracheal, intraosseous, or intracardial every 3-5 minutes.

Pediatric doses: 0.01 mg/kg-0.3 mg/m2 with single doses not to exceed 0.5 mg.

CPR and arrythmias pediatric: 0.01 mg/kg

CPR and arrythmias neonates: 0.01-0.03 mg/kg

Dosage range/use for Procrit

Initial dose in chronic renal failure: 50-100 units/kg 3 times weekly until hematocrit reaches 30-33% or hemoglobin is 10 g/dL. Doses should then be reduced by 25 units/kg and titrated to response.

Zidovudine-induced anemia: initiated at 100 units/kg IV or SQ 3 times weekly for 8-12 weeks.

Chemotherapy induced anemia: 150 units/kg SQ 3 times weekly.

Dosage range/use for Ertapenem

Treatment of complicated intra-abdominal infections due to E.coli, C. clostridioforme, E. lentum, B. fragilis, B. distasomis, B. ovatus, B. thetaiotaomicron, or B. uniformis: 1 g given once a day for 5-14 days.

Treatment of community acquired pneumonia due to S. pnuemoniae, H. influenzae, or M. catarrhalis: 1 g given once a day for 10-14 days.

Treatment of complicated UTIs including pyelonephritis due to E.coli: 1 g given once a day for 10-14 days.

Treatment of acute pelvic infections including postpartum endomyometritis, septic abortion, and post-surgical gynecologic infections: 1 gram given once daily for 3-10 days.

CrCl < 30 mL/min and end-stage renal insufficiency: 500 mg given once a day (6 hrs before dialysis)

Dosage range/use for Erythromycin

Severe infections in adults and children: 15-20 mg/kg daily given by continuous IV infusion or by intermittent infusion every 6 hrs. Very severe infections have required 4 g/day.

Treatment of PID caused by N. gonorrheae: 500 mg IV every 6 hrs for at least 3 days followed by oral therapy (no longer preferred)

Legionnaires disease: 1-4 g daily given in divided doses every 6 hrs. (no longer preferred)

Dosage range/use for Nexium

Treatment of GERD: 20-40 mg once daily for no more than 10 days.

Hepatic impairment: should not exceed 20 mg/day

Dosage range/use for Pepcid

Treatment of gastric and duodenal ulcers: 20 mg every 12 hrs.

Hypersecretory conditions: 20 mg every 6 hrs, subsequent IV doses should be titrated to patients requirements and response.

May need to be adjusted in renal dysfunction

Dosage range/use for Sublimaze

For sedation in minor procedures and analgesia:

Children 1-12 years old: 1-2 mcg/kg/dose IV or IM, may repeat at 30-60 minute intervals. Max dose is 5 mcg/kg/hr

Adults and children > 12: 25-50 mcg IV, repeat every 3-5 minutes till desired effect. Max dose is 500 mcg/4 hrs.

For surgery in adults (premedication): 25-100 mcg/dose (slow IV) over 1-2 minutes.

As adjunct to anesthesia: 0.5-50 mcg/kg/dose (slow IV)

Acute pain management: 50-100 mcg/dose IM or IV every 1-2 hrs as needed.

Dosage range/use for Filgrastim

Initial dose: 5 mcg/kg daily for up to 2 weeks, or until ANC reaches 10,000 units/mm3 in patients that are in post-antineoplastic therapy states.

Bone marrow transplantation: 10 mcg/kg/day and adjusted accordingly

Dosage range/use for Fluconazole

Identical to oral doses:

For oropharyngeal and esophageal candidiasis: 200 mg initially followed by 100 mg once daily for 2 weeks.

Systemic infections and meningitis: 400 mg initially with 200 mg daily doses for 4 weeks for up to 19 months.

Patients with impaired renal function: 50-400 mg as a loading dose.

CrCl 21-50 mL/min: 50% of recommended dose

CrCl 11-20 mL/min: use 25% of recommended dose.

Dosage range/use for Foscarnet

Induction of cytomegalovirus (CMV) retinitis: 60 mg/kg/dose every 8 hrs or 90 mg/kg every 12 hrs for 14-21 days.

Maintenance dose: 90-120 mg/kg/day as a single infusion.

Herpes simplex virus (acyclovir resistant): 40 mg/kg/dose every 12 hrs for 14-21 days.

Dosage range/use for Cerebyx

For control of generalized convulsive status epilepticus and prevention/treatment of seizures occurring during neurosurgery.

Loading dose: 15-20 mg PE/kg administered at 100-150 PE/min. Continuous monitoring of EKG, BP, and respiratory function is essential.

Nonemergent loading and maintenance dose: 4-6 mg PE/kg/day.

Dosage range/use for Furosemide

Adult dose: 20-40 mg given IV or IM as a single injection. Dosage may be titrated in 20 mg increments/2 hrs until desired response is obtained.

Pulmonary edema: 40 mg given slowly over 1-2 minutes, if desired effect is not seen in 1 hr give double the dose.

Adults with acute/chronic renal failure: 100 mg- 2 g with a max dose of 8 g/day

Infants and children with CHF or acute pulmonary edema: 1 mg/kg increased at 1 mg intervals every 6-12 hrs until response up to a 6 mg/kg/dose.

Dosage range/use for Cytovene

Adults and children > 3 months: 5 mg/kg every 12 hrs initially, continued for 14-21 days (7-14 prophylactically).

Maintenance therapy: consists of 5 mg/kg daily or 6 mg/kg daily for 5 days per week.

Reductions may be needed for renal impairment

Dosage range/use for Tequin

Acute bacterial exacerbation of chronic bronchitis due to S. pneumoniae, H. influenzae, H. parainfluenzae, M. catarrhalis, or S. aureus: 400 mg daily for 5 days.

Acute sinusitis caused by S. pneumoniae or H. influenzae: 400 mg daily for 5 days.

Community acquired pneumonia: 400 mg daily for 7-14 days

CrCl < 40 mL/min: 400 mg initially, followed by 200 mg IV every 24 hrs.

Dosage range/use for Garamycin

Usual IM/IV dose in adults: 4 mg/kg given once daily.

Life-threatening infections: 7 mg/kg daily may be used, peak trough levels should be monitored and desirable peaks range from 4-10 mcg/mL

Children: 6-7.5 mg/kg daily in equally divided doses at 8 hr intervals.

Infants/neonates: 7.5 mg/kg daily divided doses at 8 hr intervals.

Premature/full-term neonates < 1 week: 2.5 mg/kg every 12 hrs

Dosage adjustments are needed for renal impairment.

Therapeutic drug level: 4-8 ug/mL

Dosage range/use for Granisetron

Prophylaxis of chemotherapy-related emesis in patients older than 2: 10 mcg/kg/dose (max 1 mg/dose) given 30 mins before chemo

For chemotherapy drugs with long onset: 10 mcg/kg every 12 hrs

No adjustment needed in renal/hepatic impairment.

Given on schedule basis not PRN (is not effective when n/v has begun)

Dosage range/use for Haldol

For prompt relief of symptoms in acutely agitated patients.

Inital dose: 2-5 mg, may be repeated every hour, although every 4-8 hr is typical.

Dosage and frequency may be titrated based on patients tolerance.

Dosage for decanoate salt: 40-80 mg, but not to exceed 100 mg total.

Dosage range/use for Heparin