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what myelinates in the PNS
schwann cells
what myelinates in the CNS
oligodendrocytes
what does myelination allow for
insulation of axons
fast electrical signals
what is the order of the impulse transmission process
signal reception
signal integration
signal conduction
signal transmission
what is meant by signal reception
incoming signals received and converted in change in membrane potential
what is meant by signal integration
change in membrane potential initiates action potential
what is meant by signal conduction
action potential are conducted to the axon terminals
what is meant by signal transmission
neurotransmitter release transmits a signal to the target area
where does anterograde transprt move to
axon terminal
what does retrograde transport move towards
cell body
what are the three meningeal layers
dura mater
arachnoid mater
pia mater
what are the layers of the dura mater
dura mater (endosteal layer)
dural sinus
dura mater (meningeal layer)
what are the layers of the arachnoid mater
arachnoid membrane
subarachnoid space
arachnoid trabeculae
what is the pia mater bound to
surface of the brain by astrocytes
what is the role of the dura mater
protect brain and spinal cord
mechanical strength
covers each nerve root with DRG
drain the brain
what are the characteristics of the dura mater (not what does it do)
thickest layer
pain sensitive
own blood supply surrounds brain and spinal cord
what are some characteristics of the arachnoid mater
more delicate
web like projection
avascular
barrier function
what are the characteristics of the pia mater
cover CNS with neural tissue
thin layer
highly vascularized
what do the dentate ligaments connect
pia mater to dura mater
what are the dentate ligaments
pia projections
band of fibrous pia mater extending along the spinal cord on each side between dorsal and ventral roots
where do the dentate ligaments have a strong attachment
upper cervical
what is the role of the dentate ligaments
support/stability of the spinal cord
what does the brain do
perception and processing of sensory stimuli
execution of voluntary motor response
regulate homeostatic mechanisms
what are the PNS nerves
fibers of sensory and motor neurons (somatic and autonomic)
what is the digestive tract
enteric nervous system
responsible for autonomic function
can operate without brain and spinal cord
what does the spinal cord do
initiate reflexes from gray matter, ventral, and lateral horn
pathway for sensory function between periphery and brain
what do the ganglia do
reception of sensory stimuli by dorsal root and cranial ganglia
relay of visceral motor responses by autonomic ganglia
what are some examples of sympathetic function
dilation of pupils and bronchioles of the lungs
increase HR, blood glucose, blood to skeletal muscles
slow peristatic action
decrease glandular secretion, blood to digestive organs
relax muscles of the gallbladder and urinary bladder
what are examples of structures that contain sympathetic nerves
thoracic and lumbar regions of the spinal cord join prevertebral ganglion and connect to vital organs
what are some examples of parasympathetic nerve function
constrict pupils and bronchioles of the lungs
decrease HR, blood glucose, blood to skeletal muscles
increase peristaltic action, glandular secretion, blood to digestive organs
contract muscles of gallbladder and urinary bladder
what are some examples of structures in the parasympathetic system
brainstem and sacral region of spinal cord to join nerve fibers in muscles and glands
where is the preganglionic neuron in a parasympathetic system
usually in the brain stem or sacral spinal cord
where is the preganglionic neuron in a sympathetic system
usually in the spine
what neurotrasnmitter is released from a parasympathetic preganglionic synapse
acetylcholine
where are parasympathetic postganglionic neurons typically
in a ganglion near target organ
where are sympathetic postganglionic neurons typically
soma in sympathetic ganglion next to the spinal cord
what neurotransmitters are released from parasympathetic postganglionic synapses
acetylcholine or nitric oxide
what neurotransmitters are released from postganglionic synapse
norepinephrine
what is the overall response from the parasympathetic system
rest and digest
what is the overall response from the sympathetic system
fight or flight
what does the cerebral cortex do
ultimate control and information processing center
what does the hypothalamus do
control maintenance functions such as eating
help govern endocrine system
linked to emotion and reward
what does reticular formation do
help control arousal
what does the medulla do specifically
control heartbeat and breathing
what is the amygdala linked to
emotion
what is the hippocampus linked to
memory
is the olfactory bulb part of the limbic system
no
entire rhinencephalon overlaps the limbic system
what is the corticolimbic system important for
learning
plasticity
how pain is perceived
how does the corticolimbic system influence learning, plasticity, and how pain is perceived
focusing attention, motivation and emotions to related particular activities or events
why is the hypothalamus so important
master integrator/coordinator of neuroendocrine activity by monitoring sensory inputs from multiple sources in CNS and PNS to direct appropriate homeostatic responses
what do nerve ending secrete
neurohormones
what do neurohormones from the hypothalamus stimulate or inhibit
release of anterior pituitary hormones
what does the submucosa plexus contain
sensory cells that communicate with the myenteric plexus and motor fibers that stimulate secretion of fluids into the lumen
what does the myenteric plexus contain
neurons responsible for regulating the enzyme output of adjacent organs
do nerve enter the lumen
no nerves where digestion occured
what organs monitor the condition of the lumen
brains in head and gut
what does the mesentery attach to
bowel to the body wall and contains major arteries veins lymphatics and external valves
what does the brain influence in the gut
motility
secretion
nutrient delivery
microbial balance
what can the gut influence
neurotransmitters
stress/anxiety
mood
behavior
what is reticular formation
web of brainstem nuclei and neurons
important relay center between higher centers and the spinal cord regulation of consciousness, posture, emotion processing and visual coordination
how do pain signals reach the cortex
via reticular formation
what are examples of CNS reflex centers
cortex
thalamus
hypothalamus
meninges
what are some examples of vestibular system reflex centers
H1 receptor?
M1 receptor
what are some examples of chemoreceptor trigger zone reflex centers
chemoreceptors
D2 receptor
NK1 receptor?
5-HT3 receptor
what are the reflex centers for vomiting center
H1 receptos
M1 receptor
NK1 receptor
5-HT3 receptor
what are exapmles of GI tract and heart reflex centers
mechanoreceptors
chemoreceptors
5-HT3 receptor
what are examples of autonomic reflex centers in the brainstem
CNS
vestibular system
chemoreceptor trigger zone
vomiting center
GI tract and heart
what kind of information flows into the dorsal horn
afferent sensory information
what kind of information flows into the ventral horn
efferent signals to muscles and gl
what are examples of motor (efferent) and descending pathways (red)
pyramidal tracts
extrapyramidal tract
what are examples of sensory and ascending (afferent) pathways
dorsal column medial lemniscus system
spinocerebellar tracts
anterolateral system
what does the anterior spinothalamic tract do
crude touch/pressure
what does the lateral spinothalamic tract do
pain
temperature
what does the spinocerebellar tract to
proprioception
what does the spinoreticular tract do
deep
chronic pain
what do the posterior/dorsal columns (medial lemniscus) do
proprioception
vibration
tactile stimulation
what can go wrong in the posterior/dorsal column
fasciculus cuneatus
fasciculus gracilis
where do the dorsal columns/medial lemniscal go to
medulla then cross to form medial lemniscus across thalamus then to cortex
where does teh spinothalamic tract go to
ascend one or two ipsilateral spinal cord segments then cross to frontralateral segment of the spinal cord then ascend to thalamus
where do the spinocerebellar tract go to
ventral tracts ascend to contralateral and ipsilateral cerebellum
what does the spinoreticular tract do
convey deep and chronic pain
what kind of pathway is a neospinothalamic
fast pain pathway
what kind of fibers does teh neospinothalamic tract use
A-delta fibers
what kind of tract is the paleospinothalamic tract
slow chronic poorly localized pain
what kind of fibers does the paleospinothalamic tract use
C-fibers
what characteristics are nerves classified by
diameter
degree of myelination
speed of conduction
what are the cutaneous fibers
A-alpha
A-beta
A-delta
C-fibers
what are the afferent fibers from visceral interoceptors
A-delta
C-fibers
what are the characteristics of A-alpha fibers
fastest/largest
heavily myelinated
proprioception
somatic efferent as well
what are the characteristics of A-beta fibers
touch
large
fast pain
myelinated
what sensations are A-beta fibers responsible for
touch/fine touch
vibration
2 pt discrimination
proprioception (spindle sensing length)
what do A-delta fibers sense
sharp initial pain
pain and temp
are A-delta fibers myelinated?
yes
are A-delta fibers afferent or efferent
afferent
what do C-fibers sense
slow nociception
touch
temp
dull aching pain
are C-fibers myelinated or unmyelinated
unmyelinated ar
are C-fibers efferent or afferent
efferent
what are the somatic motor neurons
A-alpha
A-gamma
what are examples of autonomic fibers
B
C-fibers
describe B-fibers
preganglionic autonomic efferent
thin myelination