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Sensation
The bottom-up process by which sensory organs detect and send information from the environment to the brain.
Perception
The top-down process where the brain interprets and organizes sensory information into meaningful experiences.
Difference between sensation and perception
Sensation collects raw input; perception gives it meaning.
Examples of chemical senses
Gustation (taste) and olfaction (smell).
Chemoreceptors
Specialized receptor cells that detect changes in chemical composition inside and outside the body.
Functions of chemical senses
Detect danger, aid in feeding and reproduction, and link strongly to emotion and memory.
Gustation definition
The sense of taste, detecting chemicals dissolved in saliva.
The six basic tastes
Bitter, Sour, Sweet, Salty, Umami, Fatty.
Function of bitter taste
Detects poison alkaloids; triggers avoidance.
Function of sour taste
Detects acidity (low pH), often signaling spoiled or unripe foods.
Function of sweet taste
Detects sugars; signals energy-rich foods.
Function of salty taste
Detects sodium chloride; helps maintain electrolyte balance.
Function of umami taste
Detects glutamate; signals protein-rich foods.
Function of fatty taste
Detects fatty acids; signals high-energy food.
Definition of flavor
Combination of gustatory, olfactory, and somatosensory information (texture, temperature).
Evolutionary purpose of taste
Survival mechanism for identifying safe and nutritious foods.
Papillae
Visible bumps on the tongue that house taste buds.
Taste buds
Clusters of 20-50 taste receptor cells located on papillae.
Taste receptor cells (TRCs)
Cells within taste buds that detect specific taste molecules and send signals to the brain.
Life span of taste receptor cells
Approximately 2 weeks; they regenerate constantly.
Why taste receptor cells regenerate
Because they are directly exposed to environmental damage through food and chemicals.
Function of gustatory afferent axons
Carry taste information from TRCs to the brain.
Transduction definition
The process of converting an environmental stimulus into an electrical signal within a sensory receptor cell.
Ionotropic transduction
Direct action of ions on receptors (used by salty and sour tastes).
Metabotropic transduction
Involves G-protein coupled receptors and second messengers (used by sweet, bitter, and umami tastes).
Salty Taste Transduction Steps
1. Na⁺ enters TRC → depolarization → opens VG Na⁺/Ca²⁺ channels → serotonin release → neuron fires.
Sour Taste Transduction Steps
1. H⁺ blocks K⁺ channels → depolarization → VG Na⁺/Ca²⁺ channels open → serotonin release → neuron fires.
Sweet, Bitter, Umami Transduction Steps
1. Food binds GPCR → G-protein activates cascade → Ca²⁺ release → depolarization → ATP release → neuron fires.
Key difference between ionotropic and metabotropic taste transduction
Ionotropic uses direct ion channels; metabotropic uses G-protein cascades.
Neurotransmitter released by salty/sour cells
Serotonin.
Neurotransmitter released by sweet/bitter/umami cells
ATP.
Cranial nerves carrying taste info
CN VII (Facial), CN IX (Glossopharyngeal), CN X (Vagus).
First brain relay for taste
Gustatory nucleus (nucleus of the solitary tract) in the medulla.
Thalamic relay nucleus for taste
Ventral posterior medial (VPM) nucleus of the thalamus.
Final cortical area for taste
Gustatory cortex (insula and frontal operculum).
Summary of taste pathway
Taste buds → CN VII/IX/X → Medulla → Thalamus (VPM) → Gustatory cortex.
Labeled line model
Each taste receptor or neuron is specialized for one taste quality.
Population coding model
The brain decodes taste by comparing patterns of activity across many neurons.
Advantage of population coding
Allows perception of countless complex flavors beyond the five/six basic tastes.
Olfaction definition
The sense of smell, detecting airborne chemicals called odorants.
Functions of olfaction
Identifying foods, detecting danger, social communication, emotional memory.
Adaptive importance of smell
Survival, reproduction, and pleasure from eating.
Example of trained olfaction
Perfumers and sommeliers improve detection and discrimination of odors with practice.
Olfactory epithelium
Sheet of cells in the upper nasal cavity where smell transduction begins.
Three main cell types of olfactory epithelium
Olfactory receptor neurons, supporting cells, and basal cells.
Olfactory receptor neuron structure
Dendrites with cilia that bind odorants; axons form CN I (olfactory nerve).
Path of odorants
Odorant → dissolves in mucus → binds to receptor on cilia → triggers electrical signal.
Cribriform plate
Tiny holes in the skull that olfactory axons pass through to reach the olfactory bulb.
Olfactory bulb
First brain structure to process olfactory information.
Mitral cells
Neurons in the olfactory bulb that receive input from ORNs and send output to the brain.
Olfactory glomeruli
Structures in the olfactory bulb where ORNs synapse onto mitral cells.
Steps of olfactory transduction
1. Odorant binds GPCR → activates G-protein → opens Ca²⁺/Na⁺ channels → depolarization → AP → mitral cell.
Type of receptor used in olfaction
G-protein coupled receptor (GPCR).
Number of olfactory receptor subtypes in humans
About 339.
How we smell thousands of odors
Combinatorial coding: each odor activates a unique combination of receptors.
Olfactory adaptation
Decreased sensitivity to a continuous odor over time.
Primary olfactory pathway
ORN → olfactory bulb → mitral cells → olfactory cortex and temporal lobe structures.
Unique feature of olfaction
It bypasses the thalamus initially.
Secondary olfactory pathway
Olfactory tubercle → medial dorsal thalamus → orbitofrontal cortex.
Role of amygdala in olfaction
Connects smell with emotional responses.
Role of hippocampus in olfaction
Links smell with memory.
Role of orbitofrontal cortex in olfaction
Conscious identification and perception of odors.
Why flavor is complex
Combination of gustatory, olfactory, and somatosensory inputs (texture, temperature).
Why food tastes bland when you have a cold
Blocked nasal passages reduce olfactory input, limiting flavor perception.
Three reasons we perceive countless flavors
Population coding of taste, combinatorial coding of smell, and cortical integration.
Six Tastes Mnemonic
SSSBUF (Sweet, Sour, Salty, Bitter, Umami, Fatty).
Taste Pathway Mnemonic
Tongue → Nerves (VII, IX, X) → Medulla → Thalamus → Cortex.
Smell Pathway Mnemonic
Odor → ORN → Bulb → Mitral → Cortex (No Thalamus first!).
Ion vs GPCR Mnemonic
Simple tastes use ions; complex tastes use cascades.