STEROIDS, PEPTIDES AND AMINO HORMONES

Steroid hormone (lipophilic or lipophobic)

lipophilic

Steroid hormone (soluble in plasma)

no, must travel bound to protein carrier

Steroid hormone Binds to (intra. or extracellular receptor?)

intracellular receptor

Steroid hormone (genomic effects?)

yes, affect DNA transcription and translation

What makes steroid hormones?

Cholesterol

Steroid hormone: location of receptors in cell?

Cytoplasm and nucleus

Steroid hormones are made..?

on demand

How to steroid hormones exit parent cell?

simple diffusion

Steroid hormones target...

induction of new protein synthesis

Examples of steroid hormones are?

estrogen, androgens, cortisol

Are peptide hormones lipophobic or lipophilic?

lipophobic

Can peptide hormones enter target cells?

No, they must combine with membrane receptors

How are peptide hormones stored?

made in advance and stored in secretory vesicles

How do peptide hormone exit parent cell?

exocytosis

What are some examples of peptide hormones?

insulin, parathyroid hormone

What is the target response of peptide hormones?

modification of existing proteins and induction of new protein synthesis

Are peptide hormone dissolved in plasma?

yes

Are peptide hormones water soluble?

yes

What is the response time for peptide hormones?

fast

TRUE OR FALSE: Do peptide hormones work through cAMP, 2nd messenger systems and sometimes tyrosine kinase receptors?

true

the 3 hormone derivatives are?

peptide, steroid and amine

Hormones

released into the blood by endocrine galnds/cells to affect distant targets.

TRUE OR FALSE: hormones can exert their effects at very low concentrations

true

Neurohormones

released into the blood by neurons to affect distant targets

How are catecholamines (amine hormone) stored and made?

made in advance and stored in secretory vesicles

How do catecholamines (amine hormones) exit parent cell?

exocytosis

Do catecholamines (amine hormones) dissolve in plasma?

yes

examples of catecholamines (amine hormones) are?

epi and norepi

Location of receptors of catecholamines (amine hormones) are?

cell membrane

what is the target of catecholamines (amine hormones)?

modify existing proteins

TRUE OR FALSE: catecholamines (amine hormones) activate 2nd messenger systems

true

How are thyroid hormones made and stored?

made in advance and stored in secretory vesicles

How do thyroid hormones exit their parent cell?

simple diffusion

How do thyroid travel through the blood?

bound to protein carriers

What is the location of thyroid hormone receptors?

nucleus

What do thyroid hormones activate?

genes for transcription and translation

What do thyroid hormones target?

induction of new protein synthesis

Examples of thyroid hormones?

thyroxine