Breast cancer questions

What is the most important prognostic factor in breast cancer?

Tumor involvement of axillary lymph nodes

Which breast cancer subtype is most commonly bilateral and multicentric?

Invasive lobular carcinoma (ILC)

What defines DCIS as Stage 0 disease?

Malignant cells confined to ducts without invasion

Which subtype presents with peau d’orange due to lymphatic obstruction?

Inflammatory breast cancer

What imaging is recommended annually for BRCA carriers?

Mammogram plus breast MRI

Which medication reduces breast cancer risk by ~50% in high‑risk women?

Tamoxifen

ifen increase endometrial cancer risk?

It acts as an estrogen agonist in endometrial tissue

Which breast cancer subtype is most common overall?

Invasive ductal carcinoma (IDC)

What is the main advantage of sentinel lymph node biopsy?

Lower risk of lymphedema and fewer complications

What is the typical presentation of Paget disease of the breast?

Scaly, erythematous, pruritic nipple lesion

Which hormone therapy is preferred for postmenopausal women?

Aromatase inhibitors

What is the most common site of distant metastasis in breast cancer?

Bone

Which mutation is most associated with male breast cancer?

BRCA2

What therapy is essential after lumpectomy for Stage I breast cancer?

Adjuvant radiation therapy

Which subtype is associated with high HER2 overexpression?

Aggravated, fast‑growing HER2‑positive tumors treated with trastuzumab