Principles of Gene Regulation and Epigenetics

Flashcards focusing on key concepts related to gene regulation and epigenetics.

Epigenetic mechanisms alter chromatin structure & affect gene expression without affecting the underlying __ sequence.

DNA

All cells in a multicellular organism develop from a single fertilized __ cell.

egg

DNA __ stabilizes or 'locks in' patterns of gene silencing.

methylation

The process of DNA methylation primarily occurs at __ dinucleotides.

CpG

Nucleosomes are composed of 146 bp of DNA wrapped around __ histone proteins.

8

Genomic imprinting involves the maintenance of inherited imprints in somatic cells through __.

mitosis

Reversible chemical modifications of DNA or histone proteins are known as __ marks.

Epigenetic

The __ gene expression favours robust offspring, even at the expense of the mother.

paternal

The __ is a common differentially methylated region regulating clusters of imprinted genes.

imprinting control region (ICR)

Dominantly inherited disorders can result from mutations that lead to inappropriate gene __ due to reduced heterochromatin.

activation