HmwkQuiz-7'_ECCS

What is the main purpose of the ECCS?

to predict the predominant mechanism of absorption and predominant mechanism of clearance, thereby predicting major mechanisms of potential drug-drug interactions

____ are the cell types found in the lining of the intestinal tract that are responsible for drug absorption and pre-systemic drug metabolism.

Enterocytes

You read that a drug is in the ECCS Class 1A. Therefore, you can predict that drug is absorbed by_ and cleared by .

absorbed by diffusion and cleared by metabolism (and mostly through UGTs and CYP2Cs).

Which ECCS class is appropriate for this combination of molecular features: MW 250 Da, Carboxylic acid in structure, pKa 3.5, highly permeable.

ECCS Class 1A

Hepatic refers to which organ?

Liver

According to the BDDCS, which TWO of the following are correct. A drug with low permeability will likely be…

absorbed mainly by intestinal or hepatic uptake transporters. cleared mainly through bile or renal.

You read that a drug is in the ECCS Class 1B. Therefore, you can predict that drug is absorbed by_ and cleared by .

absorbed by hepatic uptake transporters like OATP and cleared by metabolism (mostly through CYP2C family enzymes).

Which definition describes the EXTENT of solubility?

How much completely dissolves in water at a specified pH, after an extended period of time.

Which definition describes the RATE of solubility?

How fast a solid completely dissolves in water at a specified pH

____ are the cell types found in the liver that are responsible for drug transport and drug metabolism.

Hepatocytes