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What is the first step in the antimicrobial decision-making process?
Is an antibiotic necessary
When deciding if you want to use an antibiotic you want to compare the potential clinical benefit verses what?
Treatment costs
Potential for violative residues
Potential for adverse drug events
Selection for AMR
What can we use to determine the legality of an antimicrobial?
AMDUCA
Prohibited
How can we determine the efficacy of an antibiotic?
Drug spectrum
AST
Clinical experience
Drug label
How can we determine the safety of an antibacterial?
Patient safety
Administrator safety
Food produce safety (residues)
How can we determine the owner compliance of an antibiotic?
Dosing regimen (route and frequency)
Cost
T/F florcon is a fluoroquinolone and is not allowed for extra label use in large animals?
False
W
What is danofloxacin labeled for?
BRD
What is mikotil?
Tilmicosin
What is mikotil (tilmicosin) labeled for?
BRD associated with Manheimia haemolyitca, Pasteurella multocida, Histophilus somni
Why would we not want to use Micotil (Tilmicosin)?
It has a 45 day withdrawal time
Dairy cattle
Can hurt human
What is sustain III?
Sulfamethazine
Why would we not use Sustain III (sulfamethazine) for BRD?
Dairy calves older than 20 months old
You have to oral bolus each calf
What is polyflex?
Ampicillin
Why would we not use polyflex (ampicillin) for BRD?
Mycoplasma is a likely pathogen and it does not cover it
Requires multiday dosage
What is NuFlor?
Florfenicol
Why would we not use florfenicol for a BRD case?
Expensive
Hard to pull up
What is excede?
CFA Ceftiofur
Why would we not use CFA ceftiofur for a BRD case?
Requires injection at base of the ear
Does not cover mycoplasma
What is Bio Mycin?
Oxytetracycline
Why would we not use BioMycin for a BRD case?
Resistance
How do you dose danofloxacin?
Single or multi
How do you dose Ceftiofur CFA?
Single
How do you dose sulfamethazine?
Single
How do you dose florfenicol?
Single or multi
How do you dose oxytetracycline?
Single or multi
How do you dose tilmicosin?
Single
How do you dose ampicillin?
Multi
What can injection of tilmicosin (micotil) do in humans?
Can be fatal to humans. Do not use if workers are poorly trained
What are some precautions of danofloxacin?
CNS stimulation
Cartilage damage in young animals
What are some safety concerns of micotil (tilmicosin) in attle?
Anaphylaxis, swelling
What are the primary BRD pathogens?
Mannheimia haemolytica
Pasteurella multocida
HIstophilus somni (gram negative anaerobe)
Mycoplasma bovis
What drugs can be used for the control of BRD?
Exceed
Danofloxacin
Florphenicol
What drugs have a short withdrawal time and can treat BRD?
Danofloxacin
Ampicillin
Sulfas can be ok (12 days)
Ceftiofur can be ok (13 days)
What drugs can be used in lactating dairy cattle with BRD?
Ceftiofur
Ampicillin
Oxytetracycline
Florfenicol (extra label but can be used technically) (long withdraw time)
Tilmicosin (long milk withdrawal time)
At what age are you no longer allowed to use sulfas in dairy cattle?
Older than 20 months
What is the milk withdrawal time for ceftiofur?
None
Note 
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