Citric Acid Cycle

Step 1

Citrate synthase catalyzes a favorable condensation of acetyl COA and oxaloacetate to form Citrate

Step 2

Aconitase catalyzes the reversible isomerization of citrate to isocitrate

Step 3

NAD+ dependent isocitrate dehydrogenase catalyzes the first oxidative decarboxylation

Step 4

a-ketoglutarate dehydrogenase catalyzes the second oxidative decarboxylation

Step 5

Succinyl-CoA synthetase catalyzes substrate level phospho to product GTP

Step 6

Succinate dehydrogenase catalyzes a redox reaction that couples Succinate oxidation to FAD reduction

Step 7

Fumarase catalyzes the hydration across the double bond

Step 8

Malate dehydrogenase catalyzes a redox that couples of malate oxidative to NAD+ reduction