Neuroinflammation Quiz 1

where are microglia from?

Yolk sac

where are astrocytes from?

neuroectoderm

where are T cells from?

thymus

where are neutrophils from?

bone marrow

what kind of immunity are neutrophils involved in?

innate immunity

what kind of immunity are T cells involved in?

adaptive immunity

the two innate immune cells of the CNS

astrocytes and microglia

a small protein that modulates immune activity

cytokine

a cytokine that promotes the migration of immune cells

chemokine

neuroimmune functions of astrocytes

glial scar formation, responding to cytokines and chemokines

which produce more cytokines and chemokines?

microglia

neuroimmune functions of microglia

surveillance, phagocytosis, cytokine and chemokine production, immune receptors

what aspect of microglia is tightly linked to function?

morphology

ramified (surveying) microglia are…

highly branched

amoeboid (reactive) microglia are…

rounded or blob-like

when do microglia become activated?

after encountering DAMPs or PAMPs

DAMP

danger-associated molecular pattern

PAMP

pathogen-associated molecular pattern

high during surveying state but low during the reactive state

P2ry12

the BBB is a part of the…

neurovascular unit

what kind of molecules can pass through the BBB via passive diffusion

lipophilic

three types of astrocytes

protoplasmic, fibrous, radial

protoplasmic astrocytes are in…

grey matter

fibrous astrocytes are in…

white matter

acute neuroinflammation

tissue repair, debris clearance

chronic neuroinflammation

tissue injury, pathology, reduced plasticity