nucleus

What forms the nuclear lamina? What is attached to it?

Laminin which is a form of intermediate filament type 5

Chromosomes are attached to the nuclear lamina through HISTONE METHYLATION

What is one disease assoicated with the nuclear lamina

Progeria

And as the nucleus morphology is affected the whole gene expression is affected

The nuclear lanina is between’

The nucleus and abd the perinuclar space

The nuclear envelope what kind of intermidate filemants contain?

Lamins which makes the nulcar lamina beneath the inner face of the nuclear envolpe

The nuclear eneveope regulates molecular trafficking via?

Nuclar piores complex that perforate the envelope and regulate the transport of proteins and rna between the nucleus and the cytoplams

When does the nuclear enevelope break

During PROPHASE to allow spindle fibes to access the chromosoes and then reform in teleophase

What separates te inner and outer memebrane of the nucleus

The PERINUCLEAR CISTERNAE

How does the inner membrane of the enevlope contact the nuclear lamins’

Through intermediate filaments and maintis it porsition by binding to integral proteins

In the outer memebrae that is continuous with the rer there is a netweork made of what kind of IF

Vimetin, a lose network of intermediate filaments

The nuclar pore complex structure

Externally theri is a cytoplasmatic ring subuinit attached to protein fibril

Internally there is a main central pore and the nucleoplasmic ring subuint and all the NUCLEAR BASKET

What does the nuclar pore complex regulate? How many rings make it? What kind of protein make this structurew?

The metabolic activity of the cell It also have channels for the SIMPLE DIFFUSION and macromolecules cannot pass thorigh them so their is a receptor mediate transport mediated by IMPORTINS AND EXPORTINS

There are 3 ring a cytoplasmatic ring attched to which their is fibril protein

A middle ring

A nuclear ring

Proteins: nucleoporins

In the nuclear pore complex what is the function of the nuclear baseket?

From he inner ring there is the nuclear basket that jelps transport outide the nucleus mrna

What is the fluid inside the nucleus?

Nucleoplasm

The nucleoplasm contains what?

Water, solutes, nuclotides ans ENZYMES AQS DNA POLYNERASE AND RNA POLUMERASE. Interchromatin, RNP AND THE nuclear MATRIX !!

Whar are the perichromatine grnaules find in the nucleoplasm

Perichromnatine is found at the margins of heterochromatine and is packed with RNP

Nuclar matrix Is the site for?

DNA REPLICATION

MRNA TRANSCRIPTION

THE NUCLAR MATRIX IS WHERE 30% RNA IS

The nucleoplasm reticulum Stores?

Store nuclear calcium !

Is continuous with the rere

In the nucleoplasm there is the nuclear matrix. Decribe this structure

Nuclear matrix is a 3d protein and rna netweork

Is the structural framework of th enucleus

( e la struttura come uno skeleton dove ce anche lamina )

The nucleolus what is the most important feture?

That is MEMBRANELESS ORGANELLE

It is not enclosed in a lipid bylaer

Ribosome production assemply of rrna and rnp

The nucleus is made of a FIBRILLAR CENTER FC A DENSE FIBRILLAR COMPONENT AND A GRANULAR COMPOnent

IN THE DENSE FIBRILLAR C. RRNA IS TRANSCRIPED

IN THE GRANULAR THE RIBOSOMIS ASSEMBLED