Overview of Hemostasis and Platelet Physiology

These flashcards encompass key concepts related to hemostasis and platelet physiology, focusing on mechanisms of hemostasis, pathways involved, and clinical evaluation techniques.

What are the two main systems that maintain hemostasis?

Primary hemostasis and Secondary hemostasis.

What triggers primary hemostasis?

Small vessel damage activates the vascular system and platelets.

What is the role of the vascular system in hemostasis?

To facilitate vasoconstriction and provide a surface for platelet adhesion.

What are the key components of primary hemostasis?

Platelet adhesion, shape change, secretion, amplification, and aggregation.

What activates the coagulation cascade?

Activation occurs through intrinsic and extrinsic pathways leading to stable clot formation.

What is the function of platelet glycoproteins in hemostasis?

They are necessary for platelet adhesion and aggregation.

What are the components of the extrinsic pathway in hemostasis?

Factors VII, III (tissue factor), and calcium.

What does the international normalized ratio (INR) measure?

It standardizes prothrombin time (PT) for monitoring anticoagulant therapy.

What is the effect of thrombin in secondary hemostasis?

It converts fibrinogen to fibrin, forming a stable clot.

What is the purpose of mixing studies in coagulation testing?

To identify factor deficiencies or the presence of circulating inhibitors.