excitation-contraction coupling in cardiac muscle

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9 Terms

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mem. depolarized by Na entry as AP begins

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depolarization open L-type Ca chan in T-tubules

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small amount of “trigger” Ca enters cytosol, contributing to cell depolarization, trigger Ca binds to, and opens, ryanodine receptor Ca chan in sarcoplasmic reticulum mem.

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Ca flows into cytosol, raising Ca conc.

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Binding of Ca to troponin exposes cross-bridge binding sites on thin filaments

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cross-bridge cycling causes force generation and sliding of thick and thin filament

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Ca-ATPase pumps return Ca to sarcoplasmic reticulum

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Ca-ATPase pumps[also Na/Ca exchangers; not shown] remove Ca from cell

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mem. is repolarized when k exits to end AP