Injury to plasma membrane, nucleic acid synthesis inhibitors, competitive inhibitors of enzymes
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7 Terms
Injury to plasma membrane
Polymyxin B
Polymyxin B
little selective toxicity
bactericidal against (-)
topical treatment of superficial infections
combined w/ bacitracin & neomycin in OTC preparation (Neosporin)
Nucleic acid synthesis inhibitors
Rifamycin, quinolones, and fluoroquinolones
Rifamycin
inhibits RNA polymerase (blocking transcription)
easily penetrats tissues inclduing CSF (cerebro-spinal fluid)
used in treatment of TB and leprosy
Quinolonese & Fluoroquinolones
inhibits DNA gyrase
treat UTIs
treats anthrax infections
Competitive inhibitors of enzymes
Sulfonamides
Sulfonamides
broad spectrum
bacteriostatic
inhibit folic acid due to structural similarity to PABA
