Classes of ER Membrane Proteins
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Last updated 5:58 PM on 10/8/25
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4 Terms
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What defines a Type I ER membrane protein?
It has an N-terminal signal sequence and a single transmembrane domain with the N-terminus in the lumen.
2
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What defines Type II and III ER membrane proteins?
They use internal signal-anchor sequences to determine their orientation across the membrane.
3
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What are hydrophobic tail-anchored proteins?
Proteins that are anchored in the membrane by a hydrophobic tail near the C-terminus.
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What is a GPI-anchored protein?
A protein initially synthesized as a transmembrane protein that is later transferred to a GPI lipid anchor on the membrane surface.
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