Mycoplasma and Intracellular Bacteria (lecture 18)

Lecture 18

What is the Structural Features of Mycoplasma?

Small free living bacterial

Cell membrane contains STEROLS

DOES NOT HAVE A CELL WALL

Resistant to cell wall disruptor antibiotics

What is the structural features of Mycoplasma pneumoniae?

Virulence: P1 adhesin

Specifically attaches to receptors located at the bases of cilia in epithelial cells lining the respiratory tracts of humans

ANTIGENIC VARIATION: superantigen, change surface

What is the clinical manifestations of Mycoplasma pneumoniae?

Extracellular bacteria: causes respiratory tract diseases. STRICTLY human

Asymptomatic carrier.

Tracheobronchitis: low grade fever, malaise, headache, dry cough

ACUTE PHARYNGITIS: tracheobronchitis symptoms worsen to include oropharynx.

What is the treatment for Mycoplasma pneumoniae?

Macrolides (Azithromycin)

Tetracyclines (doxycycline)

Fluroquinolones

What is the clinical manifestations for M. hominis?

Kidney inflammation, postpartum fever, pelvic inflammatory disease in women

What is the treatment for M. hominis?

RESISTANT to macrolides and Fluoroquinolones

Clindamycin is used

What is the structural features of M. genitalium?

More likely to happen in women

What is the clinical manifestations of M. genitalium?

Urethral inflammation, cervicitis, and pelvic inflammatory disease in women

What is the treatment for M. genitalium?

RESISTANT TO macrolides and fluoroquinolones

Clindamycin is used.

FINISH RICKETTSIA