Looks like no one added any tags here yet for you.
What is gout
Characterized by pain and inflammation in joints
Excessive uric acid
Stages of gout
1)Asymptomatic hyperuricemia
2)Acute gout
3)Intercritical phase
4)Chronic gout
How to treat stage 2 acute gout
NSAIDs
Colchicine
Glucocorticoids
Oxaprozin
How to treat chronic gout
Allopurinol
Febuxostat
Probenecid
Pegloticase
Colcohine
Binds tubulin, prevents microtubule polymerization
-inhibits cell dividion
Narrow therapeutic index
Reduce inflammation primarily by inhibiting leukocyte migration and decreasing phagocytosis.
CYP3A4 inhibitors actually increase plasma levels of colchicine
GI side effects
Interactions: Tacrolimus, Cyclosporine, Verapamil
Xanthine oxidase inhibitors to lowe rurate levels
Allopurinol, Febuxostat
Drug interactions: Azathioprine, 6 mercap
Allopurinol increase levels of hypoxanthine and xanthine in the
body
Uricosuric agents to increase excretion
Probenecid
Losartan
Recombinant uricase for breakdown drugs
Pegloticase- gout flare
Rasburicase- tumor lysis syndrome
dont use in G6PD
Pegloticase
Rasburicase