Gout
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9 Terms
What is gout
Characterized by pain and inflammation in joints
Excessive uric acid
Stages of gout
1)Asymptomatic hyperuricemia
2)Acute gout
3)Intercritical phase
4)Chronic gout
How to treat stage 2 acute gout
NSAIDs
Colchicine
Glucocorticoids
Oxaprozin
How to treat chronic gout
Allopurinol
Febuxostat
Probenecid
Pegloticase
Colcohine
Binds tubulin, prevents microtubule polymerization
-inhibits cell dividion
Narrow therapeutic index
Reduce inflammation primarily by inhibiting leukocyte migration and decreasing phagocytosis.
CYP3A4 inhibitors actually increase plasma levels of colchicine
GI side effects
Interactions: Tacrolimus, Cyclosporine, Verapamil
Xanthine oxidase inhibitors to lowe rurate levels
Allopurinol, Febuxostat
Drug interactions: Azathioprine, 6 mercap
Allopurinol increase levels of hypoxanthine and xanthine in the
body
Uricosuric agents to increase excretion
Probenecid
Losartan
Recombinant uricase for breakdown drugs
Pegloticase- gout flare
Rasburicase- tumor lysis syndrome
dont use in G6PD
Pegloticase
Rasburicase
Note 
Flashcards (22)