Pathogenic Eukaryotes & Bacteriophages

week 12

Virus Replication Lytic cycle

1. Host recognition

2. Genome entry

3. Synthesis

4. Assembly of virion

5. Exit and Transmission

1. Host recognition

Tail fibers attach to structures on cell envelopes

2. Genome entry

Lysozyme release degrades membranes and peptidoglycan

3. Synthesis

Slowly degrade host DNA

Sequester central dogma

Late proteins- Structural phage proteins

4. Assembly

Assemble parts

1. Insert replicated nucleic acid into icosahedral head

2. Attach tail and sheath

3. Attach tail fibers

5. Release

Cytoplasmic membrane

Cell wall 

Outer membrane

200 T4 phages released

Lytic cylce

Virulen phage (quickly replicates killing host cell)

Lysogenic cycle

Temperate phage (Bacteriophage is quiescent)