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Circadian Rhythms
Internal cycle of activity that takes about 24 hrs
Diurnal
Awake in the day, asleep at night
Nocturnal
Awake at night, asleep during the day
Crepuscular
Active during dusk and dawn
Zeitgeber
Time keeper, info about time of day from light, temperature, or clocks
Suprachiasmatic Nucleus
biological clock, direct connection to optic nerve, activates LS
How is melatonin produced
Info from SCN says its dark, info to PG
Polysomnography
Sleep research and diagnosing sleep disorders
What do the three main measurements measure (EOG)
Electrical potential from eyes, track eye movement
What do the three main measurements measure (EMG)
electrical potential from muscle, track facial movement
What do the three main measurements measure (EEG)
neural activity of cerebral cortex, shows stages of sleep
Characteristics of sleep stages throughout the night (Awake)
Beta (dyssynchronous) alpha (relaxed)
Characteristics of sleep stages throughout the night (Asleep S1)
Theta waves- more synced, transition between wakefulness and sleep
Characteristics of sleep stages throughout the night (Asleep S2)
Sleep spindles (bursts of synced waves), memory consolidation, k-complex (triggered by noise)
Characteristics of sleep stages throughout the night (Asleep S3)
Delta activity 25 mins after falling asleep, large synced waves, little eye and muscle movement, lowest level of consciousness
Characteristics of sleep stages throughout the night (Asleep S4)
REM sleep, desynced brain, activity looks like you’re awake, muscles are paralyzed
What unique motor behavior occurs during REM sleep
Muscles are paralyzed except for eyes, which move around
Ventrolateral Preoptic Nucleus of the Hypothalamus (VLPO)
Produces GABA- inhibits wakefulness
Raphe Nuclei
Produces serotonin, communicates w/ cerebral cortex
Adenosine
engaged with high levels of metabolic activity, produced when awake, inhibits sleep
How does Adenosin accumulate?
More is produced when you are awake, making you more and more tired
How does Adenosine caffeine impact it?
Counteracts it
Activation Synthesis Hypothesis
Dreams have no deeper meaning, are a biproduct of arousal of hippocampus and cerebral cortex
Obstructive Sleep Apnea
Airway is blocked by muscles in the throat (relaxed, do not let air pass)
Central Sleep Apnea
CNS fails to tell the body to breathe
Homeostasis
Body maintaining balance
Negative Feedback Loop
Effects of regulatory system slow down or stop feedback (sweating, shivering)
Allostasis
Anticipating physiological needs rather than reacting to them (takes a physical toll on body, moves set point)
Glucose
Creates energy. Muscle tissues break down fat when there isn’t any. Body can function without it but the brain cannot.
Glycogen
glucose is converted into this because glucose cannot be stored
How are insulin and glucagon involved
Insulin converts glucose > glycogen
Glycogen > glucose using glucagon
What produces these hormones (Insulin & Glucagon)?
Pancreas
Cholecystokinin (CCK)
Feeling full as soon as we eat something with fat in it
What brain structure is most involved in various aspects of homeostasis?
Hypothalamus
Lateral Hypothalamus
Stimulated= start eating (feeding center)
Ventromedial Hypothalamus
Stimulated= stop eating
Ghrelin
thinking about when to eat, increases with fasting, decreases with eating
Leptin
Secreted by fat cells, regulates food intake, decreases with hunger
Organum Vasculosum of the Lamina Terminalis (OVLT)
detects water and salt concentration
Preoptic Area of the Hypothalamus (POA)
Maintains thermoregulation
What do endocrine glands secrete?
Hormones
Pituitary Gland
below the thalamus, anterior and posterior lobe “master gland”
Sexual Dimorphism
Sexes have different physical characteristics
Primary Sex Characteristics
Genitals
Secondary Sex Characteristics
Breasts, Adam’s apple
Brain differences (men)
10% larger, stronger front to back connections, optimized motor skills
Brain differences (women)
stronger side to side differences, optimized for intuitive thinking, more grey matter
Mullerian Systems/Ducts
Female genetics
Wolffian Systems/Ducts
Male genetics
Oxytocin
When in females- mate for life
Males- no effect
Vasopressin and Voles
When in males- want to mate for life
Females before mating- did not want to mate anymore
What causes masculinization of the brain
Androgens
Intersex
male born w/ female characteristics or vise versa
Congenital Adrenal Hyperplasia (CAH)
XX, Ambiguous sexual characteristics, earlier puberty, deeper voice, more acne, shorter, facial hair
James-Lange Theory of emotion
Emotion arises from physiological arousal (Not crying bc you’re sad, sad bc you’re crying)
Cannon-Bard theory of emotion
Physiological arousal and emotional experience happens @ same time but seperately
Schachter-Singer theory of emotion
Focused on cognition, emotions = physiological & cognitive response
Ventromedial Prefrontal Cortex (vmPFC)
Gut feeling
Role the amygdala plays in emotion
detect and process fear, collection of nuclei
Behavior associated with Periaqueductal Gray (PAG)
aggressive behavior
Distress
bad stress
Eustress
good stress
SAM System (Functional differences)
Fast stress response, like a match
HPA Axis (Functional differences)
Slower acting stress response, like a bonfire
HPA Axis (Pathway)
Hypothalamus > Pituitary > ACTH > Adrenal Cortex > Gluccocortiroid > CORTISOL
Glucocorticoids
Create cortisol
Adverse Childhood Experiences (ACEs)
Track and see impact (long term) of childhood trauma